| Transactions |
| Date | Team | Player | Type | OthTm | EffDate | When |
| 3/31/1981 | PAK | Bench | Traded away | ROC | | After |
| 3/31/1981 | PAK | Brenly | Acquired via trade | ROC | | After |
| 3/31/1981 | PAK | Harrah | Traded away | ROC | | After |
| 3/31/1981 | PAK | Leonard | Acquired via trade | ROC | | After |
| 3/31/1981 | ROC | Bench | Acquired via trade | PAK | | After |
| 3/31/1981 | ROC | Brenly | Traded away | PAK | | After |
| 3/31/1981 | ROC | Harrah | Acquired via trade | PAK | | After |
| 3/31/1981 | ROC | Leonard | Traded away | PAK | | After |
| 4/1/1981 | PAK | DeJesus | Promoted to active roster | | | Before |
| 4/1/1981 | PAK | Scott,T | Demoted to reserve roster | | | Before |
| 4/1/1981 | ROC | Fischlin | Demoted to reserve roster | | | Before |
| 4/4/1981 | AVI | Bergman | Promoted to active roster | | | Before |
| 4/4/1981 | AVI | Milner,E | Demoted to reserve roster | | | Before |
| 4/4/1981 | CAR | Cerone | Demoted to reserve roster | | | Before |
| 4/4/1981 | CAR | Davis,J | Promoted to active roster | | | Before |
| 4/4/1981 | ROC | Armstrong | Promoted to active roster | | | Before |
| 4/4/1981 | ROC | Drago | Demoted to reserve roster | | | Before |
| 4/4/1981 | ROC | Hoyt | Promoted to active roster | | | Before |
| 4/4/1981 | ROC | Lee,B | Demoted to reserve roster | | | Before |
| 4/4/1981 | ROC | Proly | Demoted to reserve roster | | | Before |
| 4/4/1981 | ROC | Whitson | Promoted to active roster | | | Before |
| 4/5/1981 | CAR | Burris | Placed on Injured List | | 4/5/1981 | Before |
| 4/5/1981 | CAR | Marshall,MG | Promoted to active roster | | | Before |
| 4/5/1981 | SPP | Pocoroba | Placed on Injured List | | 4/5/1981 | Before |
| 4/5/1981 | SPP | Pujols | Promoted to active roster | | | Before |
| 4/6/1981 | ASP | Brouhard | Promoted to active roster | | | Before |
| 4/6/1981 | ASP | Hall,M | Demoted to reserve roster | | | Before |
| 4/6/1981 | HAM | Harper,T | Promoted to active roster | | | Before |
| 4/6/1981 | HAM | Marshall,MA | Demoted to reserve roster | | | Before |
| 4/6/1981 | ROC | Garcia,Dam | Demoted to reserve roster | | | Before |
| 4/6/1981 | ROC | Roenicke,G | Promoted to active roster | | | Before |
| 4/11/1981 | ASP | DiPino | Demoted to reserve roster | | | Before |
| 4/11/1981 | ASP | Hammaker | Promoted to active roster | | | Before |
| 4/11/1981 | HNT | Moore,D | Demoted to reserve roster | | | Before |
| 4/11/1981 | HNT | Redfern | Promoted to active roster | | | Before |
| 4/12/1981 | NOR | Linares | Demoted to reserve roster | | | Before |
| 4/12/1981 | NOR | Sadek | Promoted to active roster | | | Before |
| 4/13/1981 | SOP | Backman | Demoted to reserve roster | | | Before |
| 4/13/1981 | SOP | Taveras | Promoted to active roster | | | Before |
| 4/14/1981 | CAR | Hickey | Promoted to active roster | | | Before |
| 4/14/1981 | CAR | Rhoden | Demoted to reserve roster | | | Before |
| 4/14/1981 | CST | Bumbry | Promoted to active roster | | | Before |
| 4/14/1981 | CST | Sundberg | Placed on Injured List | | 4/14/1981 | Before |
| 4/14/1981 | RIN | Grubb | Promoted to active roster | | | Before |
| 4/14/1981 | RIN | Nettles,G | Demoted to reserve roster | | | Before |
| 4/15/1981 | CAR | Hickey | Demoted to reserve roster | | | Before |
| 4/15/1981 | CAR | Griffin,A | Traded away | RDG | | After |
| 4/15/1981 | CAR | Tekulve | Acquired via trade | RDG | | After |
| 4/15/1981 | RDG | Kaat | Promoted to active roster | | | Before |
| 4/15/1981 | RDG | Griffin,A | Acquired via trade | CAR | | After |
| 4/15/1981 | RDG | Tekulve | Traded away | CAR | | After |
| 4/17/1981 | HAM | Easler | Promoted to active roster | | | Before |
| 4/17/1981 | HAM | Lynn | Placed on Injured List | | 4/17/1981 | Before |
| 4/17/1981 | OKI | Gullickson | Placed on Injured List | | 4/17/1981 | Before |
| 4/17/1981 | OKI | Smith,Br | Promoted to active roster | | | Before |
| 4/21/1981 | ROC | Garcia,Dam | Promoted to active roster | | | Before |
| 4/21/1981 | ROC | McKay | Placed on Injured List | | 4/21/1981 | Before |
| 4/22/1981 | CAR | Burris | Activated from Injured List | | | Before |
| 4/22/1981 | CAR | Chalk | Promoted to active roster | | | Before |
| 4/22/1981 | CAR | Dawson | Placed on Injured List | | 4/22/1981 | Before |
| 4/22/1981 | CAR | Johnson,JH | Demoted to reserve roster | | | Before |
| 4/22/1981 | NOR | Linares | Promoted to active roster | | | Before |
| 4/22/1981 | NOR | Sadek | Demoted to reserve roster | | | Before |
| 4/22/1981 | OKI | Benedict | Placed on Injured List | | 4/22/1981 | Before |
| 4/22/1981 | OKI | Yost | Promoted to active roster | | | Before |
| 4/22/1981 | PAK | Nolan | Placed on Injured List | | 4/21/1981 | Before |
| 4/22/1981 | PAK | O'Berry | Promoted to active roster | | | Before |
| 4/22/1981 | QME | Aponte | Demoted to reserve roster | | | Before |
| 4/22/1981 | QME | Garvin | Promoted to active roster | | | Before |
| 4/22/1981 | RIN | Lefebvre | Placed on Injured List | | 4/22/1981 | Before |
| 4/22/1981 | RIN | Reed,R | Promoted to active roster | | | Before |
| 4/22/1981 | SOP | Fletcher | Demoted to reserve roster | | | Before |
| 4/22/1981 | SPP | Werth | Promoted to active roster | | | Before |
| 4/22/1981 | SPP | Woods,G | Demoted to reserve roster | | | Before |
| 4/24/1981 | SOP | Belanger | Promoted to active roster | | | Before |
| 4/25/1981 | HNT | Balboni | Demoted to reserve roster | | | Before |
| 4/25/1981 | RIN | Lefebvre | Placed on Injured List | | 4/22/1981 | Before |
| 4/25/1981 | RIN | Lefebvre | Placed on Injured List | | 4/22/1981 | Before |
| 4/25/1981 | SOP | Harper,B | Promoted to active roster | | | Before |
| 4/25/1981 | SOP | Parker | Placed on Injured List | | 4/25/1981 | Before |
| 4/26/1981 | HNT | Butera | Promoted to active roster | | | Before |
| 4/26/1981 | QME | DeLeon | Demoted to reserve roster | | | Before |
| 4/26/1981 | QME | Tidrow | Promoted to active roster | | | Before |
| 4/29/1981 | CST | Boddicker | Demoted to reserve roster | | | Before |
| 4/29/1981 | CST | Leary | Promoted to active roster | | | Before |
| 4/29/1981 | SOP | Campaneris | Demoted to reserve roster | | | Before |
| 4/29/1981 | SOP | Reitz | Promoted to active roster | | | Before |
| 4/29/1981 | SOP | Sanchez,O | Promoted to active roster | | | Before |
| 4/29/1981 | SOP | Simmons | Placed on Injured List | | 4/28/1981 | Before |
| 4/30/1981 | NOR | Cey | Placed on Injured List | | 4/30/1981 | Before |
| 4/30/1981 | NOR | Mulliniks | Promoted to active roster | | | Before |
| 4/30/1981 | RIN | Butcher | Promoted to active roster | | | Before |
| 4/30/1981 | RIN | Ojeda | Demoted to reserve roster | | | Before |
| 4/30/1981 | SPP | Werth | Demoted to reserve roster | | | Before |
| 4/30/1981 | SPP | Woods,G | Promoted to active roster | | | Before |
| 5/2/1981 | AND | Camacho | Promoted to active roster | | | Before |
| 5/2/1981 | AND | Harris,G | Placed on Injured List | | 5/1/1981 | Before |
| 5/2/1981 | AND | Lamp | Placed on Injured List | | 5/1/1981 | Before |
| 5/2/1981 | AND | Mahler,M | Promoted to active roster | | | Before |
| 5/2/1981 | ASP | Christenson | Placed on Injured List | | 5/1/1981 | Before |
| 5/2/1981 | ASP | Jones,O | Promoted to active roster | | | Before |
| 5/2/1981 | RDG | Griffin,A | Promoted to active roster | | | Before |
| 5/2/1981 | RDG | Russell | Placed on Injured List | | 5/1/1981 | Before |
| 5/2/1981 | SOP | Harper,B | Demoted to reserve roster | | | Before |
| 5/2/1981 | SOP | Tabler | Promoted to active roster | | | Before |
| 5/3/1981 | ASP | Davis,Ma | Placed on Injured List | | 5/3/1981 | Before |
| 5/3/1981 | ASP | Watson | Promoted to active roster | | | Before |
| 5/3/1981 | OKI | Gullickson | Activated from Injured List | | | Before |
| 5/3/1981 | OKI | Smith,Br | Demoted to reserve roster | | | Before |
| 5/3/1981 | PAK | Brenly | Demoted to reserve roster | | | Before |
| 5/3/1981 | SPP | Augustine | Promoted to active roster | | | Before |
| 5/3/1981 | SPP | Cowens | Placed on Injured List | | 5/3/1981 | Before |
| 5/4/1981 | QME | Dernier | Promoted to active roster | | | Before |
| 5/4/1981 | QME | Tenace | Placed on Injured List | | 5/2/1981 | Before |
| 5/5/1981 | CST | Bumbry | Demoted to reserve roster | | | Before |
| 5/5/1981 | CST | Sundberg | Activated from Injured List | | | Before |
| 5/5/1981 | NOR | Jefferson | Promoted to active roster | | | Before |
| 5/5/1981 | NOR | Noles | Demoted to reserve roster | | | Before |
| 5/5/1981 | RIN | Garber | Placed on Injured List | | 5/5/1981 | Before |
| 5/5/1981 | RIN | Grubb | Demoted to reserve roster | | | Before |
| 5/5/1981 | RIN | Hurdle | Promoted to active roster | | | Before |
| 5/5/1981 | RIN | Nettles,G | Promoted to active roster | | | Before |
| 5/5/1981 | RIN | Rozema | Promoted to active roster | | | Before |
| 5/5/1981 | RIN | Youngblood | Demoted to reserve roster | | | Before |
| 5/5/1981 | ROC | Armstrong | Demoted to reserve roster | | | Before |
| 5/5/1981 | ROC | Lee,B | Promoted to active roster | | | Before |
| 5/6/1981 | PAK | Davis,C | Promoted to active roster | | | Before |
| 5/6/1981 | PAK | Nolan | Activated from Injured List | | | Before |
| 5/6/1981 | PAK | O'Berry | Demoted to reserve roster | | | Before |
| 5/7/1981 | AVI | Driessen | Promoted to active roster | | | Before |
| 5/7/1981 | AVI | Hrbek | Demoted to reserve roster | | | Before |
| 5/7/1981 | CAR | Chalk | Demoted to reserve roster | | | Before |
| 5/7/1981 | CAR | Dawson | Activated from Injured List | | | Before |
| 5/7/1981 | QME | Corcoran | Promoted to active roster | | | Before |
| 5/7/1981 | QME | Dernier | Demoted to reserve roster | | | Before |
| 5/7/1981 | RDG | Leibrandt | Placed on Injured List | | 5/7/1981 | Before |
| 5/7/1981 | RDG | Welsh | Promoted to active roster | | | Before |
| 5/7/1981 | RIN | Butcher | Placed on Injured List | | 5/7/1981 | Before |
| 5/7/1981 | RIN | Hrabosky | Demoted to reserve roster | | | Before |
| 5/7/1981 | RIN | Lefebvre | Activated from Injured List | | | Before |
| 5/7/1981 | RIN | Vuckovich | Promoted to active roster | | | Before |
| 5/7/1981 | ROC | Garcia,Dam | Demoted to reserve roster | | | Before |
| 5/7/1981 | ROC | McKay | Activated from Injured List | | | Before |
| 5/7/1981 | ROC | Parrish,Lr | Promoted to active roster | | | Before |
| 5/7/1981 | SPP | Biittner | Promoted to active roster | | | Before |
| 5/7/1981 | SPP | Murray,D | Demoted to reserve roster | | | Before |
| 5/7/1981 | SPP | Ripken | Demoted to reserve roster | | | Before |
| 5/7/1981 | SPP | Veryzer | Promoted to active roster | | | Before |
| 5/8/1981 | SPP | Meyer | Promoted to active roster | | | Before |
| 5/8/1981 | SPP | Pocoroba | Activated from Injured List | | | Before |
| 5/8/1981 | SPP | Pujols | Demoted to reserve roster | | | Before |
| 5/8/1981 | SPP | Veryzer | Placed on Injured List | | 5/8/1981 | Before |
| 5/9/1981 | HNT | Gaetti | Demoted to reserve roster | | | Before |
| 5/9/1981 | HNT | Havens | Promoted to active roster | | | Before |
| 5/9/1981 | HNT | Hurst | Demoted to reserve roster | | | Before |
| 5/9/1981 | HNT | Picciolo | Promoted to active roster | | | Before |
| 5/9/1981 | QME | Brunansky | Demoted to reserve roster | | | Before |
| 5/9/1981 | QME | May,L | Promoted to active roster | | | Before |
| 5/11/1981 | HAM | Boggs | Demoted to reserve roster | | | Before |
| 5/11/1981 | HAM | Boone,D | Promoted to active roster | | | Before |
| 5/11/1981 | OKI | Comer | Placed on Injured List | | 5/10/1981 | Before |
| 5/11/1981 | OKI | Schatzeder | Promoted to active roster | | | Before |
| 5/11/1981 | PAK | Forster | Promoted to active roster | | | Before |
| 5/11/1981 | PAK | LaPoint | Demoted to reserve roster | | | Before |
| 5/11/1981 | PAK | Sandberg | Demoted to reserve roster | | | Before |
| 5/11/1981 | PAK | Searage | Promoted to active roster | | | Before |
| 5/12/1981 | NOR | Blue | Placed on Injured List | | 5/12/1981 | Before |
| 5/12/1981 | NOR | Bomback | Promoted to active roster | | | Before |
| 5/14/1981 | ASP | Ainge | Demoted to reserve roster | | | Before |
| 5/14/1981 | ASP | Frazier | Promoted to active roster | | | Before |
| 5/15/1981 | PAK | LaPoint | Demoted to reserve roster | | | Before |
| 5/15/1981 | PAK | LaPoint | Promoted to active roster | | | Before |
| 5/15/1981 | PAK | Power | Demoted to reserve roster | | | Before |
| 5/15/1981 | PAK | Shirley | Promoted to active roster | | | Before |
| 5/15/1981 | ROC | Johnson,C | Placed on Injured List | | 5/15/1981 | Before |
| 5/15/1981 | ROC | Landrum | Promoted to active roster | | | Before |
| 5/16/1981 | RDG | Griffin,A | Demoted to reserve roster | | | Before |
| 5/16/1981 | RDG | Russell | Activated from Injured List | | | Before |
| 5/17/1981 | CAR | Cerone | Promoted to active roster | | | Before |
| 5/17/1981 | CAR | Davis,J | Placed on Injured List | | 5/17/1981 | Before |
| 5/17/1981 | SPP | Garner | Placed on Injured List | | 5/17/1981 | Before |
| 5/17/1981 | SPP | Ripken | Promoted to active roster | | | Before |
| 5/17/1981 | SPP | Splittorff | Promoted to active roster | | | Before |
| 5/17/1981 | SPP | Sutcliffe | Demoted to reserve roster | | | Before |
| 5/19/1981 | AND | Black | Promoted to active roster | | | Before |
| 5/19/1981 | AND | Camacho | Demoted to reserve roster | | | Before |
| 5/19/1981 | AND | Davis,Mi | Promoted to active roster | | | Before |
| 5/19/1981 | AND | Forsch,B | Placed on Injured List | | 5/18/1981 | Before |
| 5/19/1981 | AND | Harris,G | Activated from Injured List | | | Before |
| 5/19/1981 | AND | Lamp | Activated from Injured List | | | Before |
| 5/19/1981 | AND | Mahler,M | Demoted to reserve roster | | | Before |
| 5/19/1981 | AND | Ray | Demoted to reserve roster | | | Before |
| 5/19/1981 | ASP | Beattie | Demoted to reserve roster | | | Before |
| 5/19/1981 | ASP | Davis,Ma | Activated from Injured List | | | Before |
| 5/20/1981 | CAR | Lisi | Promoted to active roster | | | Before |
| 5/20/1981 | CAR | Moreno,O | Placed on Injured List | | 5/18/1981 | Before |
| 5/21/1981 | ASP | Christenson | Activated from Injured List | | | Before |
| 5/21/1981 | ASP | Jones,O | Demoted to reserve roster | | | Before |
| 5/21/1981 | HAM | Martin,Jo | Placed on Injured List | | 5/21/1981 | Before |
| 5/21/1981 | HAM | Todd | Promoted to active roster | | | Before |
| 5/22/1981 | RIN | Hrabosky | Promoted to active roster | | | Before |
| 5/22/1981 | RIN | Reed,R | Demoted to reserve roster | | | Before |
| 5/23/1981 | HAM | Easler | Demoted to reserve roster | | | Before |
| 5/23/1981 | HAM | Lynn | Activated from Injured List | | | Before |
| 5/23/1981 | RIN | Nettles,G | Demoted to reserve roster | | | Before |
| 5/23/1981 | RIN | Rincon | Promoted to active roster | | | Before |
| 5/23/1981 | SPP | Biittner | Demoted to reserve roster | | | Before |
| 5/23/1981 | SPP | Cowens | Activated from Injured List | | | Before |
| 5/24/1981 | SOP | Sanchez,O | Demoted to reserve roster | | | Before |
| 5/24/1981 | SOP | Simmons | Activated from Injured List | | | Before |
| 5/25/1981 | OKI | Comer | Activated from Injured List | | | Before |
| 5/25/1981 | OKI | Schatzeder | Demoted to reserve roster | | | Before |
| 5/25/1981 | RDG | Leibrandt | Activated from Injured List | | | Before |
| 5/25/1981 | RDG | Show | Demoted to reserve roster | | | Before |
| 5/25/1981 | RDG | Wallach | Demoted to reserve roster | | | Before |
| 5/25/1981 | RDG | Wallach | Promoted to active roster | | | Before |
| 5/25/1981 | RIN | Butcher | Activated from Injured List | | | Before |
| 5/25/1981 | RIN | Hurdle | Demoted to reserve roster | | | Before |
| 5/25/1981 | RIN | Vuckovich | Demoted to reserve roster | | | Before |
| 5/25/1981 | RIN | Youngblood | Promoted to active roster | | | Before |
| 5/27/1981 | NOR | Anderson,J | Promoted to active roster | | | Before |
| 5/27/1981 | NOR | Blue | Activated from Injured List | | | Before |
| 5/27/1981 | NOR | Bomback | Demoted to reserve roster | | | Before |
| 5/27/1981 | NOR | Mulliniks | Demoted to reserve roster | | | Before |
| 5/28/1981 | AND | Black | Demoted to reserve roster | | | Before |
| 5/28/1981 | AND | Bochte | Placed on Injured List | | 5/26/1981 | Before |
| 5/28/1981 | AND | Camacho | Promoted to active roster | | | Before |
| 5/28/1981 | AND | Eichelberger | Promoted to active roster | | | Before |
| 5/28/1981 | AND | Lamp | Placed on Injured List | | 5/25/1981 | Before |
| 5/28/1981 | AND | Maldonado | Promoted to active roster | | | Before |
| 5/28/1981 | ROC | Lynch | Promoted to active roster | | | Before |
| 5/28/1981 | ROC | Proly | Promoted to active roster | | | Before |
| 5/28/1981 | ROC | Wilcox | Demoted to reserve roster | | | Before |
| 5/29/1981 | RIN | Garber | Promoted to active roster | | | Before |
| 5/29/1981 | RIN | Hrabosky | Demoted to reserve roster | | | Before |
| 5/29/1981 | RIN | Ojeda | Promoted to active roster | | | Before |
| 5/29/1981 | RIN | Rincon | Placed on Injured List | | 5/29/1981 | Before |
| 5/29/1981 | ROC | Koosman | Demoted to reserve roster | | | Before |
| 5/31/1981 | OKI | Fahey | Acquired via trade | RDG | | After |
| 5/31/1981 | QME | Smith,Re | Demoted to reserve roster | | | Before |
| 5/31/1981 | QME | Tenace | Activated from Injured List | | | Before |
| 5/31/1981 | RDG | Fahey | Traded away | OKI | | After |
| 6/1/1981 | PAK | Hobson | Promoted to active roster | | | Before |
| 6/1/1981 | PAK | Putnam | Placed on Injured List | | 6/1/1981 | Before |
| 6/1/1981 | RIN | Cruz,H | Promoted to active roster | | | Before |
| 6/1/1981 | RIN | Grote | Promoted to active roster | | | Before |
| 6/1/1981 | RIN | May,M | Demoted to reserve roster | | | Before |
| 6/1/1981 | RIN | Pittman | Promoted to active roster | | | Before |
| 6/1/1981 | RIN | Rozema | Demoted to reserve roster | | | Before |
| 6/1/1981 | RIN | White,F | Demoted to reserve roster | | | Before |
| 6/1/1981 | SPP | Garner | Activated from Injured List | | | Before |
| 6/1/1981 | SPP | Ripken | Demoted to reserve roster | | | Before |
| 6/5/1981 | ASP | Davis,Ma | Demoted to reserve roster | | | Before |
| 6/5/1981 | ASP | Jones,O | Promoted to active roster | | | Before |
| 6/5/1981 | HAM | Martin,Jo | Activated from Injured List | | | Before |
| 6/5/1981 | HAM | Todd | Demoted to reserve roster | | | Before |
| 6/8/1981 | HAM | Easler | Promoted to active roster | | | Before |
| 6/8/1981 | HAM | Harper,T | Demoted to reserve roster | | | Before |
| 6/8/1981 | HAM | Marshall,MA | Demoted to reserve roster | | | Before |
| 6/8/1981 | HAM | Marshall,MA | Promoted to active roster | | | Before |
| 6/8/1981 | PAK | Leonard | Demoted to reserve roster | | | Before |
| 6/8/1981 | PAK | Scott,T | Promoted to active roster | | | Before |
| 6/8/1981 | RIN | Butcher | Demoted to reserve roster | | | Before |
| 6/8/1981 | RIN | Falcone | Promoted to active roster | | | Before |
| 6/9/1981 | OKI | Bailor | Demoted to reserve roster | | | Before |
| 6/9/1981 | OKI | Benedict | Activated from Injured List | | | Before |
| 6/9/1981 | OKI | Manuel | Promoted to active roster | | | Before |
| 6/9/1981 | OKI | Yost | Demoted to reserve roster | | | Before |
| 6/9/1981 | PAK | Davis,C | Demoted to reserve roster | | | Before |
| 6/9/1981 | PAK | Nicosia | Promoted to active roster | | | Before |
| 6/9/1981 | SPP | Pryor | Demoted to reserve roster | | | Before |
| 6/9/1981 | SPP | Veryzer | Activated from Injured List | | | Before |
| 6/10/1981 | AND | Bochte | Activated from Injured List | | | Before |
| 6/10/1981 | AND | Camacho | Demoted to reserve roster | | | Before |
| 6/10/1981 | AND | Davis,Mi | Demoted to reserve roster | | | Before |
| 6/10/1981 | AND | Eichelberger | Demoted to reserve roster | | | Before |
| 6/10/1981 | AND | Forsch,B | Activated from Injured List | | | Before |
| 6/10/1981 | AND | Lamp | Activated from Injured List | | | Before |
| 6/10/1981 | CAR | Lisi | Demoted to reserve roster | | | Before |
| 6/10/1981 | CAR | Moreno,O | Activated from Injured List | | | Before |
| 6/11/1981 | ASP | Graham | Promoted to active roster | | | Before |
| 6/11/1981 | ASP | Martinez,B | Demoted to reserve roster | | | Before |
| 6/11/1981 | CST | Alvarez | Promoted to active roster | | | Before |
| 6/11/1981 | CST | Leary | Demoted to reserve roster | | | Before |
| 6/11/1981 | RDG | Quirk | Promoted to active roster | | | Before |
| 6/11/1981 | RDG | Wallach | Demoted to reserve roster | | | Before |
| 6/11/1981 | RIN | Cruz,H | Demoted to reserve roster | | | Before |
| 6/11/1981 | RIN | Nettles,G | Promoted to active roster | | | Before |
| 6/12/1981 | RIN | Stein,B | Demoted to reserve roster | | | Before |
| 6/12/1981 | RIN | White,F | Promoted to active roster | | | Before |
| 6/13/1981 | OKI | Cox,T | Promoted to active roster | | | Before |
| 6/13/1981 | OKI | Evans,Da | Placed on Injured List | | 6/11/1981 | Before |
| 6/14/1981 | AND | Bosley | Promoted to active roster | | | Before |
| 6/14/1981 | AND | Maldonado | Demoted to reserve roster | | | Before |
| 6/14/1981 | AND | Moore,C | Demoted to reserve roster | | | Before |
| 6/14/1981 | AND | Wathan | Promoted to active roster | | | Before |
| 6/14/1981 | CAR | Burris | Demoted to reserve roster | | | Before |
| 6/14/1981 | CAR | Cerone | Demoted to reserve roster | | | Before |
| 6/14/1981 | CAR | Chalk | Promoted to active roster | | | Before |
| 6/14/1981 | CAR | Davis,J | Activated from Injured List | | | Before |
| 6/14/1981 | CAR | Marshall,MG | Demoted to reserve roster | | | Before |
| 6/14/1981 | CAR | Robinson,Do | Promoted to active roster | | | Before |
| 6/14/1981 | CAR | Rodriguez | Demoted to reserve roster | | | Before |
| 6/14/1981 | CAR | Buckner | Traded away | NOR | | After |
| 6/14/1981 | CAR | Hargrove | Acquired via trade | NOR | | After |
| 6/14/1981 | CAR | Hooton | Acquired via trade | NOR | | After |
| 6/14/1981 | CAR | Rhoden | Traded away | NOR | | After |
| 6/14/1981 | NOR | Breining | Promoted to active roster | | | Before |
| 6/14/1981 | NOR | Linares | Demoted to reserve roster | | | Before |
| 6/14/1981 | NOR | Littlefield | Demoted to reserve roster | | | Before |
| 6/14/1981 | NOR | Mayberry | Demoted to reserve roster | | | Before |
| 6/14/1981 | NOR | Miller,R | Promoted to active roster | | | Before |
| 6/14/1981 | NOR | Noles | Promoted to active roster | | | Before |
| 6/14/1981 | NOR | Rhoden | Promoted to active roster | | | Before |
| 6/14/1981 | NOR | Barfield | Acquired via trade | ROC | | After |
| 6/14/1981 | NOR | Blue | Traded away | ROC | | After |
| 6/14/1981 | NOR | Buckner | Acquired via trade | CAR | | After |
| 6/14/1981 | NOR | Drago | Acquired via trade | ROC | | After |
| 6/14/1981 | NOR | Gamble | Traded away | ROC | | After |
| 6/14/1981 | NOR | Hargrove | Traded away | CAR | | After |
| 6/14/1981 | NOR | Hooton | Traded away | CAR | | After |
| 6/14/1981 | NOR | Orta | Traded away | ROC | | After |
| 6/14/1981 | NOR | Proly | Acquired via trade | ROC | | After |
| 6/14/1981 | NOR | Rhoden | Acquired via trade | CAR | | After |
| 6/14/1981 | NOR | Sambito | Traded away | ROC | | After |
| 6/14/1981 | RIN | Grote | Demoted to reserve roster | | | Before |
| 6/14/1981 | RIN | May,M | Promoted to active roster | | | Before |
| 6/14/1981 | ROC | Gamble | Promoted to active roster | | | Before |
| 6/14/1981 | ROC | Lee,B | Demoted to reserve roster | | | Before |
| 6/14/1981 | ROC | Barfield | Traded away | NOR | | After |
| 6/14/1981 | ROC | Blue | Acquired via trade | NOR | | After |
| 6/14/1981 | ROC | Drago | Traded away | NOR | | After |
| 6/14/1981 | ROC | Gamble | Acquired via trade | NOR | | After |
| 6/14/1981 | ROC | Orta | Acquired via trade | NOR | | After |
| 6/14/1981 | ROC | Proly | Traded away | NOR | | After |
| 6/14/1981 | ROC | Sambito | Acquired via trade | NOR | | After |
| 6/15/1981 | OKI | Cox,T | Placed on Injured List | | 6/15/1981 | Before |
| 6/15/1981 | OKI | Ramsey | Promoted to active roster | | | Before |
| 6/15/1981 | SOP | Castillo,R | Promoted to active roster | | | Before |
| 6/15/1981 | SOP | Orosco | Demoted to reserve roster | | | Before |
| 6/16/1981 | AVI | Matthews | Promoted to active roster | | | Before |
| 6/16/1981 | AVI | Upshaw | Demoted to reserve roster | | | Before |
| 6/17/1981 | NOR | Anderson,J | Demoted to reserve roster | | | Before |
| 6/17/1981 | NOR | Barfield | Demoted to reserve roster | | | Before |
| 6/17/1981 | NOR | Cey | Activated from Injured List | | | Before |
| 6/17/1981 | NOR | Washington,R | Promoted to active roster | | | Before |
| 6/18/1981 | RIN | Davis,D | Promoted to active roster | | | Before |
| 6/18/1981 | RIN | Youngblood | Demoted to reserve roster | | | Before |
| 6/20/1981 | OKI | Benedict | Placed on Injured List | | 6/19/1981 | Before |
| 6/20/1981 | OKI | Fahey | Promoted to active roster | | | Before |
| 6/20/1981 | RIN | Lefebvre | Placed on Injured List | | 6/19/1981 | Before |
| 6/20/1981 | RIN | Youngblood | Promoted to active roster | | | Before |
| 6/21/1981 | HAM | Hausman | Promoted to active roster | | | Before |
| 6/21/1981 | HAM | Rainey | Demoted to reserve roster | | | Before |
| 6/22/1981 | ASP | Hough | Demoted to reserve roster | | | Before |
| 6/22/1981 | ASP | Lerch | Promoted to active roster | | | Before |
| 6/22/1981 | HAM | Bedrosian | Demoted to reserve roster | | | Before |
| 6/22/1981 | HAM | Todd | Promoted to active roster | | | Before |
| 6/22/1981 | QME | McGraw | Demoted to reserve roster | | | Before |
| 6/22/1981 | QME | Parrott | Promoted to active roster | | | Before |
| 6/22/1981 | QME | Renko | Promoted to active roster | | | Before |
| 6/22/1981 | QME | Reuss | Placed on Injured List | | 6/18/1981 | Before |
| 6/22/1981 | QME | Smith,Lo | Demoted to reserve roster | | | Before |
| 6/22/1981 | QME | Thompson,S | Promoted to active roster | | | Before |
| 6/22/1981 | SPP | Cruz,V | Demoted to reserve roster | | | Before |
| 6/22/1981 | SPP | Slaton | Promoted to active roster | | | Before |
| 6/23/1981 | CST | Alvarez | Demoted to reserve roster | | | Before |
| 6/23/1981 | RIN | Grubb | Promoted to active roster | | | Before |
| 6/23/1981 | RIN | Nettles,G | Demoted to reserve roster | | | Before |
| 6/24/1981 | ROC | Spillner | Demoted to reserve roster | | | Before |
| 6/24/1981 | ROC | Wilcox | Promoted to active roster | | | Before |
| 6/25/1981 | AVI | Bergman | Demoted to reserve roster | | | Before |
| 6/25/1981 | AVI | Sakata | Promoted to active roster | | | Before |
| 6/26/1981 | HAM | Boggs | Traded away | RDG | | After |
| 6/26/1981 | HAM | Eastwick | Acquired via trade | RDG | | After |
| 6/26/1981 | HAM | Foster | Acquired via trade | RDG | | After |
| 6/26/1981 | HAM | Gura | Acquired via trade | RDG | | After |
| 6/26/1981 | HAM | Hanna | Traded away | RDG | | After |
| 6/26/1981 | HAM | Lynn | Traded away | RDG | | After |
| 6/26/1981 | HAM | Seaver | Acquired via trade | RDG | | After |
| 6/26/1981 | HAM | Stapleton | Traded away | RDG | | After |
| 6/26/1981 | RDG | Griffin,A | Demoted to reserve roster | | | Before |
| 6/26/1981 | RDG | Griffin,A | Promoted to active roster | | | Before |
| 6/26/1981 | RDG | Quirk | Demoted to reserve roster | | | Before |
| 6/26/1981 | RDG | Wallach | Promoted to active roster | | | Before |
| 6/26/1981 | RDG | Boggs | Acquired via trade | HAM | | After |
| 6/26/1981 | RDG | Eastwick | Traded away | HAM | | After |
| 6/26/1981 | RDG | Foster | Traded away | HAM | | After |
| 6/26/1981 | RDG | Gura | Traded away | HAM | | After |
| 6/26/1981 | RDG | Hanna | Acquired via trade | HAM | | After |
| 6/26/1981 | RDG | Lynn | Acquired via trade | HAM | | After |
| 6/26/1981 | RDG | Nettles,G | Acquired via trade | RIN | | After |
| 6/26/1981 | RDG | Seaver | Traded away | HAM | | After |
| 6/26/1981 | RDG | Stapleton | Traded away | RIN | | After |
| 6/26/1981 | RDG | Stapleton | Acquired via trade | HAM | | After |
| 6/26/1981 | RIN | Nettles,G | Traded away | RDG | | After |
| 6/26/1981 | RIN | Stapleton | Acquired via trade | RDG | | After |
| 6/27/1981 | ASP | Gleaton | Promoted to active roster | | | Before |
| 6/27/1981 | ASP | Peņa,A | Demoted to reserve roster | | | Before |
| 6/27/1981 | HAM | Boone,D | Demoted to reserve roster | | | Before |
| 6/27/1981 | HAM | Hausman | Demoted to reserve roster | | | Before |
| 6/27/1981 | HAM | Todd | Demoted to reserve roster | | | Before |
| 6/27/1981 | RDG | Boggs | Promoted to active roster | | | Before |
| 6/27/1981 | RDG | Capilla | Promoted to active roster | | | Before |
| 6/27/1981 | RDG | Erickson | Demoted to reserve roster | | | Before |
| 6/27/1981 | RDG | Foote | Demoted to reserve roster | | | Before |
| 6/27/1981 | RDG | Hanna | Promoted to active roster | | | Before |
| 6/27/1981 | RDG | Leibrandt | Demoted to reserve roster | | | Before |
| 6/27/1981 | RDG | Miller,D | Promoted to active roster | | | Before |
| 6/27/1981 | RDG | Mura | Promoted to active roster | | | Before |
| 6/27/1981 | RDG | Nettles,G | Promoted to active roster | | | Before |
| 6/27/1981 | RDG | Quirk | Promoted to active roster | | | Before |
| 6/27/1981 | RDG | Waits | Promoted to active roster | | | Before |
| 6/27/1981 | RDG | Wallach | Demoted to reserve roster | | | Before |
| 6/27/1981 | RDG | Wiggins | Demoted to reserve roster | | | Before |
| 6/27/1981 | RIN | Pittman | Demoted to reserve roster | | | Before |
| 6/27/1981 | RIN | Stapleton | Promoted to active roster | | | Before |
| 7/1/1981 | ASP | Beattie | Promoted to active roster | | | Before |
| 7/1/1981 | ASP | Niedenfuer | Demoted to reserve roster | | | Before |
| 7/1/1981 | ASP | Niedenfuer | Demoted to reserve roster | | | Before |
| 7/1/1981 | OKI | Evans,Da | Activated from Injured List | | | Before |
| 7/1/1981 | OKI | Ramsey | Demoted to reserve roster | | | Before |
| 7/1/1981 | SOP | Bando,C | Demoted to reserve roster | | | Before |
| 7/1/1981 | SOP | Ferguson | Promoted to active roster | | | Before |
| 7/3/1981 | HAM | Bibby | Demoted to reserve roster | | | Before |
| 7/3/1981 | HAM | Hausman | Promoted to active roster | | | Before |
| 7/3/1981 | NOR | Barfield | Promoted to active roster | | | Before |
| 7/3/1981 | NOR | Keough | Demoted to reserve roster | | | Before |
| 7/3/1981 | NOR | Littlefield | Promoted to active roster | | | Before |
| 7/3/1981 | NOR | Molitor | Demoted to reserve roster | | | Before |
| 7/3/1981 | PAK | Leonard | Promoted to active roster | | | Before |
| 7/3/1981 | PAK | Oester | Placed on Injured List | | 7/2/1981 | Before |
| 7/4/1981 | HNT | Schmidt,DJ | Promoted to active roster | | | Before |
| 7/4/1981 | HNT | Stewart,D | Demoted to reserve roster | | | Before |
| 7/4/1981 | PAK | Beniquez | Promoted to active roster | | | Before |
| 7/4/1981 | PAK | Leonard | Demoted to reserve roster | | | Before |
| 7/4/1981 | RIN | Lefebvre | Activated from Injured List | | | Before |
| 7/4/1981 | RIN | Youngblood | Demoted to reserve roster | | | Before |
| 7/5/1981 | AVI | Law,V | Promoted to active roster | | | Before |
| 7/5/1981 | AVI | Wynegar | Demoted to reserve roster | | | Before |
| 7/5/1981 | OKI | Benedict | Activated from Injured List | | | Before |
| 7/5/1981 | OKI | Fahey | Demoted to reserve roster | | | Before |
| 7/5/1981 | QME | Caudill | Demoted to reserve roster | | | Before |
| 7/5/1981 | QME | Reuss | Activated from Injured List | | | Before |
| 7/6/1981 | AND | Baylor | Placed on Injured List | | 7/6/1981 | Before |
| 7/6/1981 | AND | Camacho | Promoted to active roster | | | Before |
| 7/6/1981 | AND | Eichelberger | Promoted to active roster | | | Before |
| 7/6/1981 | AND | Hernandez,W | Demoted to reserve roster | | | Before |
| 7/6/1981 | AND | Mazzilli | Promoted to active roster | | | Before |
| 7/6/1981 | AND | Moore,C | Promoted to active roster | | | Before |
| 7/6/1981 | AND | Tudor | Demoted to reserve roster | | | Before |
| 7/6/1981 | AND | Whitt | Demoted to reserve roster | | | Before |
| 7/6/1981 | AVI | Brookens | Demoted to reserve roster | | | Before |
| 7/6/1981 | AVI | Salazar | Promoted to active roster | | | Before |
| 7/6/1981 | CST | Agosto | Promoted to active roster | | | Before |
| 7/6/1981 | RIN | Davis,D | Placed on Injured List | | 7/6/1981 | Before |
| 7/6/1981 | RIN | Hurdle | Promoted to active roster | | | Before |
| 7/7/1981 | OKI | Butler | Demoted to reserve roster | | | Before |
| 7/7/1981 | OKI | Nichols | Promoted to active roster | | | Before |
| 7/10/1981 | ROC | Johnson,C | Activated from Injured List | | | Before |
| 7/10/1981 | ROC | Parrish,Lr | Demoted to reserve roster | | | Before |
| 7/10/1981 | SPP | Biittner | Promoted to active roster | | | Before |
| 7/10/1981 | SPP | Brett,G | Placed on Injured List | | 7/9/1981 | Before |
| 7/10/1981 | SPP | LaCoss | Promoted to active roster | | | Before |
| 7/10/1981 | SPP | Lollar | Demoted to reserve roster | | | Before |
| 7/11/1981 | ASP | Flannery | Promoted to active roster | | | Before |
| 7/11/1981 | ASP | Madlock | Demoted to reserve roster | | | Before |
| 7/11/1981 | ROC | Orta | Promoted to active roster | | | Before |
| 7/11/1981 | ROC | Thomas,G | Placed on Injured List | | 7/11/1981 | Before |
| 7/12/1981 | AVI | Burgmeier | Demoted to reserve roster | | | Before |
| 7/12/1981 | AVI | Candelaria | Promoted to active roster | | | Before |
| 7/12/1981 | CST | Perry | Promoted to active roster | | | Before |
| 7/12/1981 | CST | Agosto | Traded away | NOR | | After |
| 7/12/1981 | CST | Bonilla | Acquired via trade | NOR | | After |
| 7/12/1981 | NOR | Agosto | Demoted to reserve roster | | | Before |
| 7/12/1981 | NOR | Cedeno | Placed on Injured List | | 7/11/1981 | Before |
| 7/12/1981 | NOR | Molitor | Promoted to active roster | | | Before |
| 7/12/1981 | NOR | Wagner | Promoted to active roster | | | Before |
| 7/12/1981 | NOR | Agosto | Acquired via trade | CST | | After |
| 7/12/1981 | NOR | Bonilla | Traded away | CST | | After |
| 7/12/1981 | QME | Howe,S | Acquired via trade | RDG | | After |
| 7/12/1981 | QME | Morgan | Acquired via trade | RDG | | After |
| 7/12/1981 | RDG | Howe,S | Traded away | QME | | After |
| 7/12/1981 | RDG | Morgan | Traded away | QME | | After |
| 7/12/1981 | RIN | Hrabosky | Promoted to active roster | | | Before |
| 7/12/1981 | RIN | Lucas | Demoted to reserve roster | | | Before |
| 7/12/1981 | ROC | Aguayo | Demoted to reserve roster | | | Before |
| 7/12/1981 | ROC | Fischlin | Promoted to active roster | | | Before |
| 7/13/1981 | AVI | Martinez,T | Placed on Injured List | | 7/13/1981 | Before |
| 7/13/1981 | AVI | Rucker | Promoted to active roster | | | Before |
| 7/13/1981 | CST | Allenson | Demoted to reserve roster | | | Before |
| 7/13/1981 | CST | Tolleson | Promoted to active roster | | | Before |
| 7/13/1981 | QME | Parrott | Demoted to reserve roster | | | Before |
| 7/13/1981 | QME | Randle | Demoted to reserve roster | | | Before |
| 7/13/1981 | RDG | Farmer | Promoted to active roster | | | Before |
| 7/13/1981 | RDG | Gross,G | Promoted to active roster | | | Before |
| 7/14/1981 | OKI | John | Placed on Injured List | | 7/14/1981 | Before |
| 7/14/1981 | OKI | Smith,Br | Promoted to active roster | | | Before |
| 7/14/1981 | RIN | Butcher | Promoted to active roster | | | Before |
| 7/14/1981 | RIN | Grote | Promoted to active roster | | | Before |
| 7/14/1981 | RIN | Grubb | Demoted to reserve roster | | | Before |
| 7/14/1981 | RIN | Krukow | Demoted to reserve roster | | | Before |
| 7/14/1981 | RIN | May,M | Demoted to reserve roster | | | Before |
| 7/14/1981 | RIN | Youngblood | Promoted to active roster | | | Before |
| 7/14/1981 | ROC | Krenchicki | Demoted to reserve roster | | | Before |
| 7/14/1981 | ROC | Krenchicki | Promoted to active roster | | | Before |
| 7/14/1981 | ROC | Krenchicki | Promoted to active roster | | | Before |
| 7/14/1981 | ROC | Landrum | Demoted to reserve roster | | | Before |
| 7/14/1981 | ROC | Parrish,Lr | Promoted to active roster | | | Before |
| 7/14/1981 | ROC | Yount | Placed on Injured List | | 7/14/1981 | Before |
| 7/15/1981 | RIN | Butcher | Demoted to reserve roster | | | Before |
| 7/15/1981 | RIN | Krukow | Promoted to active roster | | | Before |
| 7/16/1981 | PAK | Forster | Demoted to reserve roster | | | Before |
| 7/16/1981 | PAK | Tyson | Signed | | | Before |
| 7/16/1981 | RIN | Grubb | Promoted to active roster | | | Before |
| 7/16/1981 | RIN | Hrabosky | Demoted to reserve roster | | | Before |
| 7/16/1981 | RIN | Stein,B | Promoted to active roster | | | Before |
| 7/16/1981 | RIN | Youngblood | Placed on Injured List | | 7/16/1981 | Before |
| 7/16/1981 | SPP | Bair | Demoted to reserve roster | | | Before |
| 7/16/1981 | SPP | Matlack | Promoted to active roster | | | Before |
| 7/18/1981 | OKI | Serna | Promoted to active roster | | | Before |
| 7/18/1981 | OKI | Smalley | Demoted to reserve roster | | | Before |
| 7/18/1981 | PAK | Beniquez | Demoted to reserve roster | | | Before |
| 7/18/1981 | PAK | Hobson | Demoted to reserve roster | | | Before |
| 7/18/1981 | PAK | Hobson | Promoted to active roster | | | Before |
| 7/18/1981 | PAK | Oester | Activated from Injured List | | | Before |
| 7/18/1981 | PAK | Putnam | Activated from Injured List | | | Before |
| 7/18/1981 | PAK | Tyson | Demoted to reserve roster | | | Before |
| 7/18/1981 | SOP | Belanger | Demoted to reserve roster | | | Before |
| 7/19/1981 | ASP | Peņa,T | Demoted to reserve roster | | | Before |
| 7/19/1981 | ASP | Ramos | Promoted to active roster | | | Before |
| 7/19/1981 | OKI | Hairston | Promoted to active roster | | | Before |
| 7/19/1981 | OKI | Monday | Demoted to reserve roster | | | Before |
| 7/20/1981 | AND | Lansford | Placed on Injured List | | 7/20/1981 | Before |
| 7/20/1981 | NOR | Mayberry | Promoted to active roster | | | Before |
| 7/20/1981 | NOR | Molitor | Placed on Injured List | | 7/20/1981 | Before |
| 7/20/1981 | RIN | Grote | Demoted to reserve roster | | | Before |
| 7/20/1981 | RIN | Laudner | Promoted to active roster | | | Before |
| 7/21/1981 | ASP | Ainge | Promoted to active roster | | | Before |
| 7/21/1981 | ASP | Brouhard | Demoted to reserve roster | | | Before |
| 7/21/1981 | ASP | Hammaker | Demoted to reserve roster | | | Before |
| 7/21/1981 | ASP | Johnstone | Promoted to active roster | | | Before |
| 7/21/1981 | CST | Allenson | Demoted to reserve roster | | | Before |
| 7/21/1981 | CST | Allenson | Promoted to active roster | | | Before |
| 7/21/1981 | CST | Allenson | Promoted to active roster | | | Before |
| 7/21/1981 | CST | Bonilla | Demoted to reserve roster | | | Before |
| 7/21/1981 | CST | Bumbry | Promoted to active roster | | | Before |
| 7/21/1981 | CST | Horner | Placed on Injured List | | 7/21/1981 | Before |
| 7/21/1981 | CST | Tolleson | Demoted to reserve roster | | | Before |
| 7/21/1981 | RIN | Davis,D | Activated from Injured List | | | Before |
| 7/21/1981 | RIN | Hurdle | Demoted to reserve roster | | | Before |
| 7/21/1981 | RIN | Lucas | Promoted to active roster | | | Before |
| 7/21/1981 | RIN | Stapleton | Demoted to reserve roster | | | Before |
| 7/22/1981 | AND | Foli | Promoted to active roster | | | Before |
| 7/22/1981 | AND | Templeton | Demoted to reserve roster | | | Before |
| 7/22/1981 | SPP | Clark,Br | Demoted to reserve roster | | | Before |
| 7/22/1981 | SPP | Langford | Promoted to active roster | | | Before |
| 7/23/1981 | AND | Baylor | Activated from Injured List | | | Before |
| 7/23/1981 | CAR | Baker,D | Placed on Injured List | | 7/23/1981 | Before |
| 7/23/1981 | CAR | Hume | Demoted to reserve roster | | | Before |
| 7/23/1981 | CAR | Marshall,MG | Promoted to active roster | | | Before |
| 7/23/1981 | CAR | Rodriguez | Promoted to active roster | | | Before |
| 7/23/1981 | OKI | Matuszek | Promoted to active roster | | | Before |
| 7/23/1981 | OKI | Staub | Demoted to reserve roster | | | Before |
| 7/24/1981 | RDG | Capilla | Demoted to reserve roster | | | Before |
| 7/24/1981 | RDG | Erickson | Promoted to active roster | | | Before |
| 7/24/1981 | RDG | Foote | Promoted to active roster | | | Before |
| 7/24/1981 | RDG | Griffin,A | Promoted to active roster | | | Before |
| 7/24/1981 | RDG | Miller,D | Demoted to reserve roster | | | Before |
| 7/24/1981 | RDG | Show | Promoted to active roster | | | Before |
| 7/25/1981 | RDG | Mura | Demoted to reserve roster | | | Before |
| 7/25/1981 | RDG | Show | Demoted to reserve roster | | | Before |
| 7/25/1981 | RIN | Grubb | Demoted to reserve roster | | | Before |
| 7/25/1981 | RIN | Rincon | Activated from Injured List | | | Before |
| 7/26/1981 | AND | Blyleven | Placed on Injured List | | 7/23/1981 | Before |
| 7/26/1981 | AND | Jones,J | Promoted to active roster | | | Before |
| 7/26/1981 | ASP | Hoffman | Promoted to active roster | | | Before |
| 7/26/1981 | ASP | Thornton | Demoted to reserve roster | | | Before |
| 7/26/1981 | RDG | Flanagan | Demoted to reserve roster | | | Before |
| 7/26/1981 | RDG | Foote | Demoted to reserve roster | | | Before |
| 7/26/1981 | RDG | Hanna | Demoted to reserve roster | | | Before |
| 7/26/1981 | RDG | Leibrandt | Promoted to active roster | | | Before |
| 7/26/1981 | RDG | Mura | Promoted to active roster | | | Before |
| 7/26/1981 | RDG | Nelson | Demoted to reserve roster | | | Before |
| 7/26/1981 | RDG | Nelson | Promoted to active roster | | | Before |
| 7/26/1981 | RDG | Russell | Demoted to reserve roster | | | Before |
| 7/26/1981 | RDG | Sax | Demoted to reserve roster | | | Before |
| 7/26/1981 | RDG | Show | Promoted to active roster | | | Before |
| 7/26/1981 | RDG | Wallach | Promoted to active roster | | | Before |
| 7/26/1981 | RDG | Wilfong | Promoted to active roster | | | Before |
| 7/26/1981 | ROC | Garcia,Dam | Promoted to active roster | | | Before |
| 7/26/1981 | ROC | Krenchicki | Demoted to reserve roster | | | Before |
| 7/26/1981 | ROC | Landrum | Promoted to active roster | | | Before |
| 7/26/1981 | ROC | Orta | Demoted to reserve roster | | | Before |
| 7/26/1981 | ROC | Thomas,G | Activated from Injured List | | | Before |
| 7/26/1981 | ROC | Thon | Demoted to reserve roster | | | Before |
| 7/27/1981 | CST | Allenson | Demoted to reserve roster | | | Before |
| 7/27/1981 | CST | Tolleson | Promoted to active roster | | | Before |
| 7/27/1981 | HAM | Ayala | Placed on Injured List | | 7/26/1981 | Before |
| 7/27/1981 | HAM | Marshall,MA | Promoted to active roster | | | Before |
| 7/27/1981 | HAM | Stoddard,B | Demoted to reserve roster | | | Before |
| 7/27/1981 | HAM | Todd | Promoted to active roster | | | Before |
| 7/27/1981 | NOR | Agosto | Promoted to active roster | | | Before |
| 7/27/1981 | NOR | Barfield | Demoted to reserve roster | | | Before |
| 7/27/1981 | NOR | Proly | Demoted to reserve roster | | | Before |
| 7/27/1981 | SOP | Jacoby | Demoted to reserve roster | | | Before |
| 7/27/1981 | SOP | Parker | Activated from Injured List | | | Before |
| 7/27/1981 | SOP | Vukovich,G | Promoted to active roster | | | Before |
| 7/27/1981 | SOP | Walling | Placed on Injured List | | 7/27/1981 | Before |
| 7/27/1981 | SPP | Parrish,Ln | Placed on Injured List | | 7/26/1981 | Before |
| 7/27/1981 | SPP | Pujols | Promoted to active roster | | | Before |
| 7/28/1981 | AVI | Martinez,T | Activated from Injured List | | | Before |
| 7/28/1981 | AVI | Rucker | Demoted to reserve roster | | | Before |
| 7/28/1981 | NOR | Cedeno | Activated from Injured List | | | Before |
| 7/28/1981 | OKI | Klutts | Demoted to reserve roster | | | Before |
| 7/28/1981 | OKI | Ramsey | Promoted to active roster | | | Before |
| 7/30/1981 | HNT | Stewart,S | Traded away | OKI | | After |
| 7/30/1981 | OKI | Leonard | Demoted to reserve roster | | | Before |
| 7/30/1981 | OKI | Stewart,S | Acquired via trade | HNT | | After |
| 7/30/1981 | ROC | Parrish,Lr | Demoted to reserve roster | | | Before |
| 7/30/1981 | ROC | Yount | Activated from Injured List | | | Before |
| 7/31/1981 | AND | Stone | Acquired via trade | QME | | After |
| 7/31/1981 | CAR | Hooton | Traded away | HAM | | After |
| 7/31/1981 | CAR | Marshall,MA | Acquired via trade | HAM | | After |
| 7/31/1981 | HAM | Hooton | Acquired via trade | CAR | | After |
| 7/31/1981 | HAM | Marshall,MA | Traded away | CAR | | After |
| 7/31/1981 | HNT | Picciolo | Demoted to reserve roster | | | Before |
| 7/31/1981 | HNT | Picciolo | Promoted to active roster | | | Before |
| 7/31/1981 | HNT | Reed,R | Promoted to active roster | | | Before |
| 7/31/1981 | HNT | Roberts,L | Promoted to active roster | | | Before |
| 7/31/1981 | HNT | Rose | Demoted to reserve roster | | | Before |
| 7/31/1981 | HNT | Rose | Promoted to active roster | | | Before |
| 7/31/1981 | HNT | Manning | Traded away | RIN | | After |
| 7/31/1981 | HNT | Reed,R | Acquired via trade | RIN | | After |
| 7/31/1981 | OKI | Leonard | Promoted to active roster | | | Before |
| 7/31/1981 | OKI | Smith,Br | Demoted to reserve roster | | | Before |
| 7/31/1981 | PAK | Nolan | Demoted to reserve roster | | | Before |
| 7/31/1981 | PAK | Tyson | Promoted to active roster | | | Before |
| 7/31/1981 | QME | Stone | Traded away | AND | | After |
| 7/31/1981 | RIN | Manning | Demoted to reserve roster | | | Before |
| 7/31/1981 | RIN | Wilson,M | Placed on Injured List | | 7/31/1981 | Before |
| 7/31/1981 | RIN | Youngblood | Activated from Injured List | | | Before |
| 7/31/1981 | RIN | Manning | Acquired via trade | HNT | | After |
| 7/31/1981 | RIN | Peters | Acquired via trade | SOP | | After |
| 7/31/1981 | RIN | Reed,R | Traded away | HNT | | After |
| 7/31/1981 | SOP | Peters | Traded away | RIN | | After |
| 8/1/1981 | AND | McWilliams | Demoted to reserve roster | | | Before |
| 8/1/1981 | AND | Stone | Promoted to active roster | | | Before |
| 8/1/1981 | CAR | Burris | Promoted to active roster | | | Before |
| 8/1/1981 | CAR | Moreno,O | Demoted to reserve roster | | | Before |
| 8/1/1981 | HAM | Essian | Promoted to active roster | | | Before |
| 8/1/1981 | HAM | Todd | Demoted to reserve roster | | | Before |
| 8/1/1981 | OKI | Crowley | Promoted to active roster | | | Before |
| 8/1/1981 | OKI | Matuszek | Demoted to reserve roster | | | Before |
| 8/1/1981 | PAK | Easterly | Demoted to reserve roster | | | Before |
| 8/1/1981 | PAK | Forster | Promoted to active roster | | | Before |
| 8/1/1981 | RIN | Grubb | Promoted to active roster | | | Before |
| 8/1/1981 | RIN | Stein,B | Demoted to reserve roster | | | Before |
| 8/1/1981 | RIN | Stein,B | Promoted to active roster | | | Before |
| 8/1/1981 | RIN | Zisk | Demoted to reserve roster | | | Before |
| 8/1/1981 | SOP | Brusstar | Promoted to active roster | | | Before |
| 8/1/1981 | SOP | North | Promoted to active roster | | | Before |
| 8/1/1981 | SOP | Reardon | Demoted to reserve roster | | | Before |
| 8/1/1981 | SPP | Griffin,T | Promoted to active roster | | | Before |
| 8/1/1981 | SPP | Jenkins | Demoted to reserve roster | | | Before |
| 8/2/1981 | OKI | Lea | Placed on Injured List | | 8/2/1981 | Before |
| 8/2/1981 | OKI | Ujdur | Promoted to active roster | | | Before |
| 8/3/1981 | AVI | Cabell | Promoted to active roster | | | Before |
| 8/3/1981 | AVI | Lowenstein | Demoted to reserve roster | | | Before |
| 8/3/1981 | RDG | Foote | Demoted to reserve roster | | | Before |
| 8/3/1981 | RDG | Foote | Promoted to active roster | | | Before |
| 8/3/1981 | RDG | Nettles,G | Placed on Injured List | | 8/3/1981 | Before |
| 8/3/1981 | RDG | Russell | Promoted to active roster | | | Before |
| 8/3/1981 | ROC | Armstrong | Promoted to active roster | | | Before |
| 8/3/1981 | ROC | Wilcox | Demoted to reserve roster | | | Before |
| 8/4/1981 | CST | Allenson | Promoted to active roster | | | Before |
| 8/4/1981 | CST | Tolleson | Demoted to reserve roster | | | Before |
| 8/4/1981 | OKI | Hairston | Demoted to reserve roster | | | Before |
| 8/4/1981 | OKI | Murcer | Promoted to active roster | | | Before |
| 8/4/1981 | QME | Hodges | Promoted to active roster | | | Before |
| 8/4/1981 | QME | Lacy | Demoted to reserve roster | | | Before |
| 8/4/1981 | RDG | Leibrandt | Demoted to reserve roster | | | Before |
| 8/5/1981 | AND | Lansford | Activated from Injured List | | | Before |
| 8/5/1981 | AND | Royster,J | Demoted to reserve roster | | | Before |
| 8/5/1981 | ASP | Flannery | Demoted to reserve roster | | | Before |
| 8/5/1981 | ASP | Stanley,F | Promoted to active roster | | | Before |
| 8/5/1981 | AVI | Andujar | Placed on Injured List | | 8/5/1981 | Before |
| 8/5/1981 | AVI | Stanton | Promoted to active roster | | | Before |
| 8/5/1981 | OKI | Clark,Bo | Promoted to active roster | | | Before |
| 8/5/1981 | OKI | Manuel | Demoted to reserve roster | | | Before |
| 8/5/1981 | QME | Randle | Promoted to active roster | | | Before |
| 8/5/1981 | QME | Washington,UL | Placed on Injured List | | 8/4/1981 | Before |
| 8/5/1981 | RIN | Phelps | Promoted to active roster | | | Before |
| 8/5/1981 | RIN | Rincon | Demoted to reserve roster | | | Before |
| 8/7/1981 | AND | Blyleven | Activated from Injured List | | | Before |
| 8/7/1981 | AND | Howell,J | Demoted to reserve roster | | | Before |
| 8/7/1981 | AVI | Babitt | Promoted to active roster | | | Before |
| 8/7/1981 | AVI | Henderson,D | Demoted to reserve roster | | | Before |
| 8/8/1981 | RDG | Hanna | Promoted to active roster | | | Before |
| 8/8/1981 | RDG | Miller,D | Promoted to active roster | | | Before |
| 8/8/1981 | RDG | Show | Demoted to reserve roster | | | Before |
| 8/9/1981 | SPP | Biittner | Demoted to reserve roster | | | Before |
| 8/9/1981 | SPP | Brett,G | Activated from Injured List | | | Before |
| 8/10/1981 | CAR | Baker,D | Activated from Injured List | | | Before |
| 8/10/1981 | CAR | Cerone | Promoted to active roster | | | Before |
| 8/10/1981 | CAR | Davis,J | Placed on Injured List | | 8/9/1981 | Before |
| 8/10/1981 | CAR | Hargrove | Placed on Injured List | | 8/6/1981 | Before |
| 8/10/1981 | CAR | Hickey | Promoted to active roster | | | Before |
| 8/10/1981 | CAR | Hume | Promoted to active roster | | | Before |
| 8/10/1981 | CAR | Marshall,MA | Demoted to reserve roster | | | Before |
| 8/10/1981 | CAR | Marshall,MG | Demoted to reserve roster | | | Before |
| 8/10/1981 | CAR | Pastore | Demoted to reserve roster | | | Before |
| 8/10/1981 | CAR | Perkins | Promoted to active roster | | | Before |
| 8/10/1981 | HAM | Ayala | Activated from Injured List | | | Before |
| 8/10/1981 | HAM | Ayala | Demoted to reserve roster | | | Before |
| 8/10/1981 | PAK | DeJesus | Demoted to reserve roster | | | Before |
| 8/10/1981 | PAK | Leonard | Promoted to active roster | | | Before |
| 8/10/1981 | SPP | Parrish,Ln | Activated from Injured List | | | Before |
| 8/10/1981 | SPP | Pujols | Demoted to reserve roster | | | Before |
| 8/11/1981 | AND | Leach | Demoted to reserve roster | | | Before |
| 8/11/1981 | ASP | Brouhard | Promoted to active roster | | | Before |
| 8/11/1981 | ASP | Jones,O | Demoted to reserve roster | | | Before |
| 8/11/1981 | ASP | Niedenfuer | Promoted to active roster | | | Before |
| 8/11/1981 | ASP | Sample | Placed on Injured List | | 8/10/1981 | Before |
| 8/11/1981 | ROC | Leal | Demoted to reserve roster | | | Before |
| 8/11/1981 | ROC | Spillner | Promoted to active roster | | | Before |
| 8/11/1981 | SPP | Bair | Promoted to active roster | | | Before |
| 8/11/1981 | SPP | Palmer,J | Demoted to reserve roster | | | Before |
| 8/13/1981 | AND | Mahler,M | Promoted to active roster | | | Before |
| 8/13/1981 | AVI | Iorg,G | Promoted to active roster | | | Before |
| 8/13/1981 | AVI | Kison | Demoted to reserve roster | | | Before |
| 8/13/1981 | OKI | John | Activated from Injured List | | | Before |
| 8/13/1981 | OKI | Ujdur | Demoted to reserve roster | | | Before |
| 8/13/1981 | SOP | Darwin | Placed on Injured List | | 8/12/1981 | Before |
| 8/13/1981 | SOP | Rowland | Promoted to active roster | | | Before |
| 8/14/1981 | PAK | Easterly | Promoted to active roster | | | Before |
| 8/14/1981 | PAK | Honeycutt | Demoted to reserve roster | | | Before |
| 8/14/1981 | ROC | Swan | Promoted to active roster | | | Before |
| 8/14/1981 | ROC | Whitson | Demoted to reserve roster | | | Before |
| 8/15/1981 | AND | Camacho | Demoted to reserve roster | | | Before |
| 8/15/1981 | AND | Hernandez,W | Promoted to active roster | | | Before |
| 8/15/1981 | AND | Howell,J | Promoted to active roster | | | Before |
| 8/15/1981 | AND | Mahler,M | Demoted to reserve roster | | | Before |
| 8/15/1981 | AND | Mazzilli | Demoted to reserve roster | | | Before |
| 8/15/1981 | AND | Tudor | Promoted to active roster | | | Before |
| 8/15/1981 | CAR | Berra | Promoted to active roster | | | Before |
| 8/15/1981 | CAR | Johnson,JH | Promoted to active roster | | | Before |
| 8/15/1981 | CAR | LaRoche | Placed on Injured List | | 8/14/1981 | Before |
| 8/15/1981 | CAR | Rodriguez | Demoted to reserve roster | | | Before |
| 8/15/1981 | RDG | Flanagan | Promoted to active roster | | | Before |
| 8/15/1981 | RDG | Goltz | Placed on Injured List | | 8/15/1981 | Before |
| 8/16/1981 | NOR | Agosto | Demoted to reserve roster | | | Before |
| 8/16/1981 | RDG | Capilla | Promoted to active roster | | | Before |
| 8/16/1981 | RDG | Erickson | Demoted to reserve roster | | | Before |
| 8/16/1981 | SOP | McGaffigan | Promoted to active roster | | | Before |
| 8/16/1981 | SOP | Rowland | Demoted to reserve roster | | | Before |
| 8/17/1981 | CAR | Cappuzzello | Promoted to active roster | | | Before |
| 8/17/1981 | CAR | Robinson,Do | Placed on Injured List | | 8/16/1981 | Before |
| 8/17/1981 | CST | Horner | Activated from Injured List | | | Before |
| 8/17/1981 | CST | Perry | Demoted to reserve roster | | | Before |
| 8/17/1981 | NOR | Proly | Promoted to active roster | | | Before |
| 8/17/1981 | OKI | Lea | Activated from Injured List | | | Before |
| 8/17/1981 | OKI | McGregor | Demoted to reserve roster | | | Before |
| 8/17/1981 | QME | Arroyo | Promoted to active roster | | | Before |
| 8/17/1981 | QME | Bannister,F | Demoted to reserve roster | | | Before |
| 8/17/1981 | QME | Clancy | Demoted to reserve roster | | | Before |
| 8/17/1981 | QME | Parrott | Promoted to active roster | | | Before |
| 8/17/1981 | ROC | Armstrong | Demoted to reserve roster | | | Before |
| 8/17/1981 | ROC | Moffitt | Promoted to active roster | | | Before |
| 8/19/1981 | HNT | Carew | Placed on Injured List | | 8/18/1981 | Before |
| 8/19/1981 | HNT | Gedman | Demoted to reserve roster | | | Before |
| 8/19/1981 | HNT | Rose | Promoted to active roster | | | Before |
| 8/19/1981 | HNT | Schmidt,DF | Promoted to active roster | | | Before |
| 8/19/1981 | SPP | Bair | Demoted to reserve roster | | | Before |
| 8/19/1981 | SPP | Biittner | Promoted to active roster | | | Before |
| 8/19/1981 | SPP | Lollar | Promoted to active roster | | | Before |
| 8/19/1981 | SPP | Robinson,B | Placed on Injured List | | 8/18/1981 | Before |
| 8/20/1981 | AVI | Andujar | Activated from Injured List | | | Before |
| 8/20/1981 | AVI | Petry | Demoted to reserve roster | | | Before |
| 8/20/1981 | PAK | DeJesus | Promoted to active roster | | | Before |
| 8/20/1981 | PAK | Sorensen | Demoted to reserve roster | | | Before |
| 8/20/1981 | SOP | Parker | Placed on Injured List | | 8/20/1981 | Before |
| 8/20/1981 | SOP | Walling | Activated from Injured List | | | Before |
| 8/21/1981 | CAR | Hargrove | Activated from Injured List | | | Before |
| 8/21/1981 | CAR | Perkins | Demoted to reserve roster | | | Before |
| 8/21/1981 | QME | Randle | Demoted to reserve roster | | | Before |
| 8/21/1981 | QME | Washington,UL | Activated from Injured List | | | Before |
| 8/21/1981 | ROC | Swan | Demoted to reserve roster | | | Before |
| 8/21/1981 | ROC | Wilcox | Promoted to active roster | | | Before |
| 8/22/1981 | ASP | Ainge | Placed on Injured List | | 8/22/1981 | Before |
| 8/22/1981 | ASP | Beattie | Demoted to reserve roster | | | Before |
| 8/22/1981 | ASP | Davis,Ma | Promoted to active roster | | | Before |
| 8/22/1981 | ASP | Flannery | Promoted to active roster | | | Before |
| 8/22/1981 | ASP | Peņa,A | Promoted to active roster | | | Before |
| 8/22/1981 | ASP | Tobik | Demoted to reserve roster | | | Before |
| 8/22/1981 | OKI | Clark,J | Placed on Injured List | | 8/21/1981 | Before |
| 8/22/1981 | OKI | Summers | Promoted to active roster | | | Before |
| 8/22/1981 | ROC | Garcia,Dam | Demoted to reserve roster | | | Before |
| 8/22/1981 | ROC | Trevino | Promoted to active roster | | | Before |
| 8/23/1981 | CAR | Dawson | Placed on Injured List | | 8/23/1981 | Before |
| 8/23/1981 | CAR | Perkins | Promoted to active roster | | | Before |
| 8/23/1981 | RDG | Foote | Promoted to active roster | | | Before |
| 8/23/1981 | RDG | Hebner | Promoted to active roster | | | Before |
| 8/23/1981 | RDG | Miller,E | Promoted to active roster | | | Before |
| 8/23/1981 | RDG | Nelson | Demoted to reserve roster | | | Before |
| 8/23/1981 | RDG | Quirk | Demoted to reserve roster | | | Before |
| 8/23/1981 | RDG | Wallach | Demoted to reserve roster | | | Before |
| 8/23/1981 | RIN | Saucier | Promoted to active roster | | | Before |
| 8/23/1981 | RIN | Vuckovich | Demoted to reserve roster | | | Before |
| 8/23/1981 | SOP | Gorman | Promoted to active roster | | | Before |
| 8/23/1981 | SOP | Price | Demoted to reserve roster | | | Before |
| 8/24/1981 | AND | Hernandez,W | Demoted to reserve roster | | | Before |
| 8/24/1981 | HNT | Schmidt,DJ | Demoted to reserve roster | | | Before |
| 8/24/1981 | HNT | Urrea | Promoted to active roster | | | Before |
| 8/25/1981 | RIN | Phelps | Demoted to reserve roster | | | Before |
| 8/25/1981 | RIN | Stapleton | Promoted to active roster | | | Before |
| 8/25/1981 | SOP | Beard | Promoted to active roster | | | Before |
| 8/25/1981 | SOP | Vukovich,G | Demoted to reserve roster | | | Before |
| 8/26/1981 | CAR | Moreno,O | Promoted to active roster | | | Before |
| 8/26/1981 | CAR | Perkins | Demoted to reserve roster | | | Before |
| 8/26/1981 | OKI | Berenyi | Demoted to reserve roster | | | Before |
| 8/26/1981 | OKI | McGregor | Promoted to active roster | | | Before |
| 8/26/1981 | QME | Corcoran | Demoted to reserve roster | | | Before |
| 8/26/1981 | QME | Ford,Dan | Promoted to active roster | | | Before |
| 8/26/1981 | ROC | Fischlin | Demoted to reserve roster | | | Before |
| 8/26/1981 | ROC | Krenchicki | Promoted to active roster | | | Before |
| 8/29/1981 | AVI | Moreland | Demoted to reserve roster | | | Before |
| 8/29/1981 | AVI | Yeager | Promoted to active roster | | | Before |
| 8/29/1981 | CST | Dotson | Demoted to reserve roster | | | Before |
| 8/29/1981 | CST | Perry | Promoted to active roster | | | Before |
| 8/30/1981 | ASP | Bonnell | Demoted to reserve roster | | | Before |
| 8/30/1981 | ASP | Sample | Activated from Injured List | | | Before |
| 8/30/1981 | RDG | Flanagan | Demoted to reserve roster | | | Before |
| 8/30/1981 | RDG | Goltz | Activated from Injured List | | | Before |
| 9/1/1981 | ASP | Hammaker | Promoted to active roster | | | Before |
| 9/1/1981 | ASP | Peņa,A | Demoted to reserve roster | | | Before |
| 9/1/1981 | AVI | Bergman | Promoted to active roster | | | Before |
| 9/1/1981 | AVI | Brookens | Promoted to active roster | | | Before |
| 9/1/1981 | AVI | Henderson,D | Promoted to active roster | | | Before |
| 9/1/1981 | AVI | Petry | Promoted to active roster | | | Before |
| 9/1/1981 | AVI | Stanton | Demoted to reserve roster | | | Before |
| 9/1/1981 | CAR | Davis,J | Activated from Injured List | | | Before |
| 9/1/1981 | CAR | Heep | Promoted to active roster | | | Before |
| 9/1/1981 | CAR | Kravec | Promoted to active roster | | | Before |
| 9/1/1981 | CAR | LaRoche | Activated from Injured List | | | Before |
| 9/1/1981 | CAR | Marshall,MA | Promoted to active roster | | | Before |
| 9/1/1981 | CAR | Marshall,MG | Promoted to active roster | | | Before |
| 9/1/1981 | CAR | Narron | Promoted to active roster | | | Before |
| 9/1/1981 | CAR | Perkins | Promoted to active roster | | | Before |
| 9/1/1981 | CAR | Rodriguez | Promoted to active roster | | | Before |
| 9/1/1981 | CST | Bonilla | Promoted to active roster | | | Before |
| 9/1/1981 | CST | Tolleson | Promoted to active roster | | | Before |
| 9/1/1981 | HAM | Ayala | Promoted to active roster | | | Before |
| 9/1/1981 | HAM | Bibby | Promoted to active roster | | | Before |
| 9/1/1981 | HAM | Boone,D | Promoted to active roster | | | Before |
| 9/1/1981 | HAM | Dillard | Promoted to active roster | | | Before |
| 9/1/1981 | HAM | Gardenhire | Promoted to active roster | | | Before |
| 9/1/1981 | HAM | Harper,T | Promoted to active roster | | | Before |
| 9/1/1981 | HAM | Iorg,D | Promoted to active roster | | | Before |
| 9/1/1981 | HAM | Newman | Promoted to active roster | | | Before |
| 9/1/1981 | HAM | Nordhagen | Promoted to active roster | | | Before |
| 9/1/1981 | HAM | Patterson,Mi | Promoted to active roster | | | Before |
| 9/1/1981 | HAM | Stoddard,B | Promoted to active roster | | | Before |
| 9/1/1981 | HAM | Todd | Promoted to active roster | | | Before |
| 9/1/1981 | OKI | Berenyi | Promoted to active roster | | | Before |
| 9/1/1981 | OKI | Cox,T | Activated from Injured List | | | Before |
| 9/1/1981 | OKI | Fahey | Promoted to active roster | | | Before |
| 9/1/1981 | OKI | Ujdur | Promoted to active roster | | | Before |
| 9/1/1981 | PAK | Beniquez | Promoted to active roster | | | Before |
| 9/1/1981 | PAK | O'Berry | Promoted to active roster | | | Before |
| 9/1/1981 | QME | Bannister,F | Promoted to active roster | | | Before |
| 9/1/1981 | QME | Caudill | Promoted to active roster | | | Before |
| 9/1/1981 | QME | Clancy | Promoted to active roster | | | Before |
| 9/1/1981 | QME | Flynn | Promoted to active roster | | | Before |
| 9/1/1981 | QME | Ivie | Promoted to active roster | | | Before |
| 9/1/1981 | QME | Kuiper | Promoted to active roster | | | Before |
| 9/1/1981 | QME | Lacy | Promoted to active roster | | | Before |
| 9/1/1981 | QME | McGraw | Promoted to active roster | | | Before |
| 9/1/1981 | QME | Randle | Promoted to active roster | | | Before |
| 9/1/1981 | QME | Smith,Lo | Promoted to active roster | | | Before |
| 9/1/1981 | RDG | Nettles,G | Activated from Injured List | | | Before |
| 9/1/1981 | RDG | Quirk | Promoted to active roster | | | Before |
| 9/1/1981 | RDG | Russell | Demoted to reserve roster | | | Before |
| 9/1/1981 | RIN | Hrabosky | Promoted to active roster | | | Before |
| 9/1/1981 | RIN | Hurdle | Promoted to active roster | | | Before |
| 9/1/1981 | RIN | Manning | Promoted to active roster | | | Before |
| 9/1/1981 | RIN | May,M | Promoted to active roster | | | Before |
| 9/1/1981 | RIN | McLaughlin,J | Promoted to active roster | | | Before |
| 9/1/1981 | RIN | Peters | Promoted to active roster | | | Before |
| 9/1/1981 | RIN | Rozema | Promoted to active roster | | | Before |
| 9/1/1981 | RIN | Youngblood | Demoted to reserve roster | | | Before |
| 9/2/1981 | RIN | Wilson,M | Activated from Injured List | | | Before |
| 9/2/1981 | SPP | Aikens | Demoted to reserve roster | | | Before |
| 9/2/1981 | SPP | Augustine | Demoted to reserve roster | | | Before |
| 9/2/1981 | SPP | Bair | Promoted to active roster | | | Before |
| 9/2/1981 | SPP | Clark,Br | Promoted to active roster | | | Before |
| 9/2/1981 | SPP | Robinson,B | Activated from Injured List | | | Before |
| 9/2/1981 | SPP | Smith,Lee | Demoted to reserve roster | | | Before |
| 9/4/1981 | OKI | Klutts | Promoted to active roster | | | Before |
| 9/4/1981 | SOP | McGaffigan | Demoted to reserve roster | | | Before |
| 9/4/1981 | SOP | Parker | Activated from Injured List | | | Before |
| 9/5/1981 | AND | Mazzilli | Promoted to active roster | | | Before |
| 9/5/1981 | AND | Perconte | Promoted to active roster | | | Before |
| 9/5/1981 | AND | Royster,J | Promoted to active roster | | | Before |
| 9/5/1981 | AND | Tudor | Demoted to reserve roster | | | Before |
| 9/5/1981 | AND | Whitt | Promoted to active roster | | | Before |
| 9/5/1981 | CAR | Marshall,MA | Demoted to reserve roster | | | Before |
| 9/5/1981 | CAR | Welch | Demoted to reserve roster | | | Before |
| 9/5/1981 | CST | Brennan | Promoted to active roster | | | Before |
| 9/5/1981 | CST | Bystrom | Promoted to active roster | | | Before |
| 9/5/1981 | CST | Gossage | Demoted to reserve roster | | | Before |
| 9/5/1981 | CST | Reed,J | Promoted to active roster | | | Before |
| 9/5/1981 | RIN | Allen,N | Promoted to active roster | | | Before |
| 9/5/1981 | RIN | Davis,D | Demoted to reserve roster | | | Before |
| 9/5/1981 | RIN | Saucier | Demoted to reserve roster | | | Before |
| 9/5/1981 | RIN | Zisk | Promoted to active roster | | | Before |
| 9/6/1981 | ASP | Ainge | Activated from Injured List | | | Before |
| 9/6/1981 | ASP | Randolph | Demoted to reserve roster | | | Before |
| 9/6/1981 | OKI | Clark,J | Activated from Injured List | | | Before |
| 9/7/1981 | ASP | Beattie | Promoted to active roster | | | Before |
| 9/7/1981 | ASP | Davis,Ma | Demoted to reserve roster | | | Before |
| 9/7/1981 | CAR | Dawson | Activated from Injured List | | | Before |
| 9/7/1981 | RIN | Wilson,M | Activated from Injured List | | | Before |
| 9/9/1981 | ASP | Hough | Promoted to active roster | | | Before |
| 9/9/1981 | ASP | Lavelle | Demoted to reserve roster | | | Before |
| 9/9/1981 | NOR | Anderson,J | Promoted to active roster | | | Before |
| 9/9/1981 | NOR | Bordi | Promoted to active roster | | | Before |
| 9/9/1981 | NOR | Keough | Promoted to active roster | | | Before |
| 9/9/1981 | NOR | Linares | Promoted to active roster | | | Before |
| 9/9/1981 | NOR | Molitor | Activated from Injured List | | | Before |
| 9/9/1981 | OKI | Klutts | Demoted to reserve roster | | | Before |
| 9/9/1981 | ROC | Blue | Demoted to reserve roster | | | Before |
| 9/9/1981 | ROC | Lee,B | Promoted to active roster | | | Before |
| 9/11/1981 | AND | Howell,J | Demoted to reserve roster | | | Before |
| 9/11/1981 | AND | Perconte | Demoted to reserve roster | | | Before |
| 9/11/1981 | AND | Templeton | Promoted to active roster | | | Before |
| 9/11/1981 | ASP | Martinez,B | Promoted to active roster | | | Before |
| 9/11/1981 | ASP | Niedenfuer | Demoted to reserve roster | | | Before |
| 9/11/1981 | HAM | Eastwick | Demoted to reserve roster | | | Before |
| 9/11/1981 | HAM | Ruhle | Demoted to reserve roster | | | Before |
| 9/11/1981 | ROC | Guidry | Demoted to reserve roster | | | Before |
| 9/11/1981 | ROC | Leal | Promoted to active roster | | | Before |
| 9/12/1981 | AND | Camacho | Promoted to active roster | | | Before |
| 9/12/1981 | NOR | Bordi | Demoted to reserve roster | | | Before |
| 9/12/1981 | SPP | Augustine | Promoted to active roster | | | Before |
| 9/13/1981 | PAK | Nolan | Promoted to active roster | | | Before |
| 9/13/1981 | QME | Tenace | Demoted to reserve roster | | | Before |
| 9/13/1981 | ROC | Alexander,M | Promoted to active roster | | | Before |
| 9/13/1981 | ROC | Geronimo | Promoted to active roster | | | Before |
| 9/13/1981 | ROC | Koosman | Promoted to active roster | | | Before |
| 9/13/1981 | ROC | Orta | Promoted to active roster | | | Before |
| 9/13/1981 | ROC | Virgil | Promoted to active roster | | | Before |
| 9/13/1981 | ROC | Whitson | Promoted to active roster | | | Before |
| 9/14/1981 | AND | Mahler,M | Promoted to active roster | | | Before |
| 9/14/1981 | CAR | Robinson,Do | Activated from Injured List | | | Before |
| 9/14/1981 | SOP | Backman | Promoted to active roster | | | Before |
| 9/14/1981 | SOP | Tabler | Demoted to reserve roster | | | Before |
| 9/15/1981 | ROC | Stargell | Promoted to active roster | | | Before |
| 9/17/1981 | RIN | Rincon | Demoted to reserve roster | | | Before |
| 9/17/1981 | RIN | Vuckovich | Promoted to active roster | | | Before |
| 9/18/1981 | ASP | Thornton | Promoted to active roster | | | Before |
| 9/18/1981 | OKI | Grich | Demoted to reserve roster | | | Before |
| 9/18/1981 | RIN | Cruz,H | Promoted to active roster | | | Before |
| 9/18/1981 | RIN | Krukow | Demoted to reserve roster | | | Before |
| 9/18/1981 | RIN | McCatty | Demoted to reserve roster | | | Before |
| 9/18/1981 | RIN | Paciorek | Demoted to reserve roster | | | Before |
| 9/19/1981 | ASP | Beattie | Demoted to reserve roster | | | Before |
| 9/19/1981 | ASP | Johnstone | Demoted to reserve roster | | | Before |
| 9/19/1981 | CAR | Carlton | Demoted to reserve roster | | | Before |
| 9/19/1981 | NOR | Rogers | Demoted to reserve roster | | | Before |
| 9/19/1981 | SOP | Campaneris | Promoted to active roster | | | Before |
| 9/19/1981 | SOP | Reitz | Demoted to reserve roster | | | Before |
| 9/20/1981 | QME | Tenace | Promoted to active roster | | | Before |
| 9/21/1981 | ASP | Jones,O | Promoted to active roster | | | Before |
| 9/21/1981 | ROC | Virgil | Demoted to reserve roster | | | Before |
| 9/21/1981 | SOP | Bando,C | Promoted to active roster | | | Before |
| 9/21/1981 | SOP | Brusstar | Demoted to reserve roster | | | Before |
| 9/23/1981 | OKI | Ramsey | Demoted to reserve roster | | | Before |
| 9/24/1981 | AND | Lamp | Demoted to reserve roster | | | Before |
| 9/24/1981 | CAR | Milbourne | Demoted to reserve roster | | | Before |
| 9/24/1981 | HNT | Abbott | Demoted to reserve roster | | | Before |
| 9/24/1981 | HNT | Allard | Promoted to active roster | | | Before |
| 9/24/1981 | HNT | Berenguer | Promoted to active roster | | | Before |
| 9/24/1981 | HNT | Trout | Demoted to reserve roster | | | Before |
| 9/24/1981 | OKI | Stewart,S | Demoted to reserve roster | | | Before |
| 9/24/1981 | PAK | Honeycutt | Promoted to active roster | | | Before |
| 9/24/1981 | PAK | Sorensen | Promoted to active roster | | | Before |
| 9/25/1981 | ASP | Brummer | Promoted to active roster | | | Before |
| 9/25/1981 | ASP | Tobik | Promoted to active roster | | | Before |
| 9/26/1981 | AND | Mahler,M | Demoted to reserve roster | | | Before |
| 9/26/1981 | HAM | Dempsey | Demoted to reserve roster | | | Before |
| 9/26/1981 | HAM | Fryman | Demoted to reserve roster | | | Before |
| 9/26/1981 | HAM | Harper,T | Demoted to reserve roster | | | Before |
| 9/27/1981 | OKI | McBride | Promoted to active roster | | | Before |
| 9/27/1981 | OKI | Ujdur | Demoted to reserve roster | | | Before |
| 9/27/1981 | ROC | Leal | Demoted to reserve roster | | | Before |
| 9/27/1981 | ROC | Wilcox | Demoted to reserve roster | | | Before |