| Transactions |
| Date | Team | Player | Type | OthTm | EffDate | When |
| 3/31/1981 | PAK | Bench | Traded away | ROC | | After |
| 3/31/1981 | PAK | Brenly | Acquired via trade | ROC | | After |
| 3/31/1981 | PAK | Harrah | Traded away | ROC | | After |
| 3/31/1981 | PAK | Leonard | Acquired via trade | ROC | | After |
| 3/31/1981 | ROC | Bench | Acquired via trade | PAK | | After |
| 3/31/1981 | ROC | Brenly | Traded away | PAK | | After |
| 3/31/1981 | ROC | Harrah | Acquired via trade | PAK | | After |
| 3/31/1981 | ROC | Leonard | Traded away | PAK | | After |
| 4/1/1981 | PAK | DeJesus | Promoted to active roster | | | Before |
| 4/1/1981 | PAK | Scott,T | Demoted to reserve roster | | | Before |
| 4/1/1981 | ROC | Fischlin | Demoted to reserve roster | | | Before |
| 4/4/1981 | AVI | Bergman | Promoted to active roster | | | Before |
| 4/4/1981 | AVI | Milner,E | Demoted to reserve roster | | | Before |
| 4/4/1981 | ROC | Armstrong | Promoted to active roster | | | Before |
| 4/4/1981 | ROC | Drago | Demoted to reserve roster | | | Before |
| 4/4/1981 | ROC | Hoyt | Promoted to active roster | | | Before |
| 4/4/1981 | ROC | Lee,B | Demoted to reserve roster | | | Before |
| 4/4/1981 | ROC | Proly | Demoted to reserve roster | | | Before |
| 4/4/1981 | ROC | Whitson | Promoted to active roster | | | Before |
| 4/6/1981 | ROC | Garcia,Dam | Demoted to reserve roster | | | Before |
| 4/6/1981 | ROC | Roenicke,G | Promoted to active roster | | | Before |
| 4/11/1981 | HNT | Moore,D | Demoted to reserve roster | | | Before |
| 4/11/1981 | HNT | Redfern | Promoted to active roster | | | Before |
| 4/13/1981 | SOP | Backman | Demoted to reserve roster | | | Before |
| 4/13/1981 | SOP | Taveras | Promoted to active roster | | | Before |
| 4/14/1981 | RIN | Grubb | Promoted to active roster | | | Before |
| 4/14/1981 | RIN | Nettles,G | Demoted to reserve roster | | | Before |
| 4/15/1981 | RDG | Kaat | Promoted to active roster | | | Before |
| 4/15/1981 | RDG | Griffin,A | Acquired via trade | CAR | | After |
| 4/15/1981 | RDG | Tekulve | Traded away | CAR | | After |
| 4/21/1981 | ROC | Garcia,Dam | Promoted to active roster | | | Before |
| 4/21/1981 | ROC | McKay | Placed on Injured List | | 4/21/1981 | Before |
| 4/22/1981 | PAK | Nolan | Placed on Injured List | | 4/21/1981 | Before |
| 4/22/1981 | PAK | O'Berry | Promoted to active roster | | | Before |
| 4/22/1981 | QME | Aponte | Demoted to reserve roster | | | Before |
| 4/22/1981 | QME | Garvin | Promoted to active roster | | | Before |
| 4/22/1981 | RIN | Lefebvre | Placed on Injured List | | 4/22/1981 | Before |
| 4/22/1981 | RIN | Reed,R | Promoted to active roster | | | Before |
| 4/22/1981 | SOP | Fletcher | Demoted to reserve roster | | | Before |
| 4/24/1981 | SOP | Belanger | Promoted to active roster | | | Before |
| 4/25/1981 | HNT | Balboni | Demoted to reserve roster | | | Before |
| 4/25/1981 | RIN | Lefebvre | Placed on Injured List | | 4/22/1981 | Before |
| 4/25/1981 | RIN | Lefebvre | Placed on Injured List | | 4/22/1981 | Before |
| 4/25/1981 | SOP | Harper,B | Promoted to active roster | | | Before |
| 4/25/1981 | SOP | Parker | Placed on Injured List | | 4/25/1981 | Before |
| 4/26/1981 | HNT | Butera | Promoted to active roster | | | Before |
| 4/26/1981 | QME | DeLeon | Demoted to reserve roster | | | Before |
| 4/26/1981 | QME | Tidrow | Promoted to active roster | | | Before |
| 4/29/1981 | SOP | Campaneris | Demoted to reserve roster | | | Before |
| 4/29/1981 | SOP | Reitz | Promoted to active roster | | | Before |
| 4/29/1981 | SOP | Sanchez,O | Promoted to active roster | | | Before |
| 4/29/1981 | SOP | Simmons | Placed on Injured List | | 4/28/1981 | Before |
| 4/30/1981 | RIN | Butcher | Promoted to active roster | | | Before |
| 4/30/1981 | RIN | Ojeda | Demoted to reserve roster | | | Before |
| 5/2/1981 | RDG | Griffin,A | Promoted to active roster | | | Before |
| 5/2/1981 | RDG | Russell | Placed on Injured List | | 5/1/1981 | Before |
| 5/2/1981 | SOP | Harper,B | Demoted to reserve roster | | | Before |
| 5/2/1981 | SOP | Tabler | Promoted to active roster | | | Before |
| 5/3/1981 | PAK | Brenly | Demoted to reserve roster | | | Before |
| 5/4/1981 | QME | Dernier | Promoted to active roster | | | Before |
| 5/4/1981 | QME | Tenace | Placed on Injured List | | 5/2/1981 | Before |
| 5/5/1981 | RIN | Garber | Placed on Injured List | | 5/5/1981 | Before |
| 5/5/1981 | RIN | Grubb | Demoted to reserve roster | | | Before |
| 5/5/1981 | RIN | Hurdle | Promoted to active roster | | | Before |
| 5/5/1981 | RIN | Nettles,G | Promoted to active roster | | | Before |
| 5/5/1981 | RIN | Rozema | Promoted to active roster | | | Before |
| 5/5/1981 | RIN | Youngblood | Demoted to reserve roster | | | Before |
| 5/5/1981 | ROC | Armstrong | Demoted to reserve roster | | | Before |
| 5/5/1981 | ROC | Lee,B | Promoted to active roster | | | Before |
| 5/6/1981 | PAK | Davis,C | Promoted to active roster | | | Before |
| 5/6/1981 | PAK | Nolan | Activated from Injured List | | | Before |
| 5/6/1981 | PAK | O'Berry | Demoted to reserve roster | | | Before |
| 5/7/1981 | AVI | Driessen | Promoted to active roster | | | Before |
| 5/7/1981 | AVI | Hrbek | Demoted to reserve roster | | | Before |
| 5/7/1981 | QME | Corcoran | Promoted to active roster | | | Before |
| 5/7/1981 | QME | Dernier | Demoted to reserve roster | | | Before |
| 5/7/1981 | RDG | Leibrandt | Placed on Injured List | | 5/7/1981 | Before |
| 5/7/1981 | RDG | Welsh | Promoted to active roster | | | Before |
| 5/7/1981 | RIN | Butcher | Placed on Injured List | | 5/7/1981 | Before |
| 5/7/1981 | RIN | Hrabosky | Demoted to reserve roster | | | Before |
| 5/7/1981 | RIN | Lefebvre | Activated from Injured List | | | Before |
| 5/7/1981 | RIN | Vuckovich | Promoted to active roster | | | Before |
| 5/7/1981 | ROC | Garcia,Dam | Demoted to reserve roster | | | Before |
| 5/7/1981 | ROC | McKay | Activated from Injured List | | | Before |
| 5/7/1981 | ROC | Parrish,Lr | Promoted to active roster | | | Before |
| 5/9/1981 | HNT | Gaetti | Demoted to reserve roster | | | Before |
| 5/9/1981 | HNT | Havens | Promoted to active roster | | | Before |
| 5/9/1981 | HNT | Hurst | Demoted to reserve roster | | | Before |
| 5/9/1981 | HNT | Picciolo | Promoted to active roster | | | Before |
| 5/9/1981 | QME | Brunansky | Demoted to reserve roster | | | Before |
| 5/9/1981 | QME | May,L | Promoted to active roster | | | Before |
| 5/11/1981 | PAK | Forster | Promoted to active roster | | | Before |
| 5/11/1981 | PAK | LaPoint | Demoted to reserve roster | | | Before |
| 5/11/1981 | PAK | Sandberg | Demoted to reserve roster | | | Before |
| 5/11/1981 | PAK | Searage | Promoted to active roster | | | Before |
| 5/15/1981 | PAK | LaPoint | Demoted to reserve roster | | | Before |
| 5/15/1981 | PAK | LaPoint | Promoted to active roster | | | Before |
| 5/15/1981 | PAK | Power | Demoted to reserve roster | | | Before |
| 5/15/1981 | PAK | Shirley | Promoted to active roster | | | Before |
| 5/15/1981 | ROC | Johnson,C | Placed on Injured List | | 5/15/1981 | Before |
| 5/15/1981 | ROC | Landrum | Promoted to active roster | | | Before |
| 5/16/1981 | RDG | Griffin,A | Demoted to reserve roster | | | Before |
| 5/16/1981 | RDG | Russell | Activated from Injured List | | | Before |
| 5/22/1981 | RIN | Hrabosky | Promoted to active roster | | | Before |
| 5/22/1981 | RIN | Reed,R | Demoted to reserve roster | | | Before |
| 5/23/1981 | RIN | Nettles,G | Demoted to reserve roster | | | Before |
| 5/23/1981 | RIN | Rincon | Promoted to active roster | | | Before |
| 5/24/1981 | SOP | Sanchez,O | Demoted to reserve roster | | | Before |
| 5/24/1981 | SOP | Simmons | Activated from Injured List | | | Before |
| 5/25/1981 | RDG | Leibrandt | Activated from Injured List | | | Before |
| 5/25/1981 | RDG | Show | Demoted to reserve roster | | | Before |
| 5/25/1981 | RDG | Wallach | Demoted to reserve roster | | | Before |
| 5/25/1981 | RDG | Wallach | Promoted to active roster | | | Before |
| 5/25/1981 | RIN | Butcher | Activated from Injured List | | | Before |
| 5/25/1981 | RIN | Hurdle | Demoted to reserve roster | | | Before |
| 5/25/1981 | RIN | Vuckovich | Demoted to reserve roster | | | Before |
| 5/25/1981 | RIN | Youngblood | Promoted to active roster | | | Before |
| 5/28/1981 | ROC | Lynch | Promoted to active roster | | | Before |
| 5/28/1981 | ROC | Proly | Promoted to active roster | | | Before |
| 5/28/1981 | ROC | Wilcox | Demoted to reserve roster | | | Before |
| 5/29/1981 | RIN | Garber | Promoted to active roster | | | Before |
| 5/29/1981 | RIN | Hrabosky | Demoted to reserve roster | | | Before |
| 5/29/1981 | RIN | Ojeda | Promoted to active roster | | | Before |
| 5/29/1981 | RIN | Rincon | Placed on Injured List | | 5/29/1981 | Before |
| 5/29/1981 | ROC | Koosman | Demoted to reserve roster | | | Before |
| 5/31/1981 | QME | Smith,Re | Demoted to reserve roster | | | Before |
| 5/31/1981 | QME | Tenace | Activated from Injured List | | | Before |
| 5/31/1981 | RDG | Fahey | Traded away | OKI | | After |
| 6/1/1981 | PAK | Hobson | Promoted to active roster | | | Before |
| 6/1/1981 | PAK | Putnam | Placed on Injured List | | 6/1/1981 | Before |
| 6/1/1981 | RIN | Cruz,H | Promoted to active roster | | | Before |
| 6/1/1981 | RIN | Grote | Promoted to active roster | | | Before |
| 6/1/1981 | RIN | May,M | Demoted to reserve roster | | | Before |
| 6/1/1981 | RIN | Pittman | Promoted to active roster | | | Before |
| 6/1/1981 | RIN | Rozema | Demoted to reserve roster | | | Before |
| 6/1/1981 | RIN | White,F | Demoted to reserve roster | | | Before |
| 6/8/1981 | PAK | Leonard | Demoted to reserve roster | | | Before |
| 6/8/1981 | PAK | Scott,T | Promoted to active roster | | | Before |
| 6/8/1981 | RIN | Butcher | Demoted to reserve roster | | | Before |
| 6/8/1981 | RIN | Falcone | Promoted to active roster | | | Before |
| 6/9/1981 | PAK | Davis,C | Demoted to reserve roster | | | Before |
| 6/9/1981 | PAK | Nicosia | Promoted to active roster | | | Before |
| 6/11/1981 | RDG | Quirk | Promoted to active roster | | | Before |
| 6/11/1981 | RDG | Wallach | Demoted to reserve roster | | | Before |
| 6/11/1981 | RIN | Cruz,H | Demoted to reserve roster | | | Before |
| 6/11/1981 | RIN | Nettles,G | Promoted to active roster | | | Before |
| 6/12/1981 | RIN | Stein,B | Demoted to reserve roster | | | Before |
| 6/12/1981 | RIN | White,F | Promoted to active roster | | | Before |
| 6/14/1981 | RIN | Grote | Demoted to reserve roster | | | Before |
| 6/14/1981 | RIN | May,M | Promoted to active roster | | | Before |
| 6/14/1981 | ROC | Gamble | Promoted to active roster | | | Before |
| 6/14/1981 | ROC | Lee,B | Demoted to reserve roster | | | Before |
| 6/14/1981 | ROC | Barfield | Traded away | NOR | | After |
| 6/14/1981 | ROC | Blue | Acquired via trade | NOR | | After |
| 6/14/1981 | ROC | Drago | Traded away | NOR | | After |
| 6/14/1981 | ROC | Gamble | Acquired via trade | NOR | | After |
| 6/14/1981 | ROC | Orta | Acquired via trade | NOR | | After |
| 6/14/1981 | ROC | Proly | Traded away | NOR | | After |
| 6/14/1981 | ROC | Sambito | Acquired via trade | NOR | | After |
| 6/15/1981 | SOP | Castillo,R | Promoted to active roster | | | Before |
| 6/15/1981 | SOP | Orosco | Demoted to reserve roster | | | Before |
| 6/16/1981 | AVI | Matthews | Promoted to active roster | | | Before |
| 6/16/1981 | AVI | Upshaw | Demoted to reserve roster | | | Before |
| 6/18/1981 | RIN | Davis,D | Promoted to active roster | | | Before |
| 6/18/1981 | RIN | Youngblood | Demoted to reserve roster | | | Before |
| 6/20/1981 | RIN | Lefebvre | Placed on Injured List | | 6/19/1981 | Before |
| 6/20/1981 | RIN | Youngblood | Promoted to active roster | | | Before |
| 6/22/1981 | QME | McGraw | Demoted to reserve roster | | | Before |
| 6/22/1981 | QME | Parrott | Promoted to active roster | | | Before |
| 6/22/1981 | QME | Renko | Promoted to active roster | | | Before |
| 6/22/1981 | QME | Reuss | Placed on Injured List | | 6/18/1981 | Before |
| 6/22/1981 | QME | Smith,Lo | Demoted to reserve roster | | | Before |
| 6/22/1981 | QME | Thompson,S | Promoted to active roster | | | Before |
| 6/23/1981 | RIN | Grubb | Promoted to active roster | | | Before |
| 6/23/1981 | RIN | Nettles,G | Demoted to reserve roster | | | Before |
| 6/24/1981 | ROC | Spillner | Demoted to reserve roster | | | Before |
| 6/24/1981 | ROC | Wilcox | Promoted to active roster | | | Before |
| 6/25/1981 | AVI | Bergman | Demoted to reserve roster | | | Before |
| 6/25/1981 | AVI | Sakata | Promoted to active roster | | | Before |
| 6/26/1981 | RDG | Griffin,A | Demoted to reserve roster | | | Before |
| 6/26/1981 | RDG | Griffin,A | Promoted to active roster | | | Before |
| 6/26/1981 | RDG | Quirk | Demoted to reserve roster | | | Before |
| 6/26/1981 | RDG | Wallach | Promoted to active roster | | | Before |
| 6/26/1981 | RDG | Boggs | Acquired via trade | HAM | | After |
| 6/26/1981 | RDG | Eastwick | Traded away | HAM | | After |
| 6/26/1981 | RDG | Foster | Traded away | HAM | | After |
| 6/26/1981 | RDG | Gura | Traded away | HAM | | After |
| 6/26/1981 | RDG | Hanna | Acquired via trade | HAM | | After |
| 6/26/1981 | RDG | Lynn | Acquired via trade | HAM | | After |
| 6/26/1981 | RDG | Nettles,G | Acquired via trade | RIN | | After |
| 6/26/1981 | RDG | Seaver | Traded away | HAM | | After |
| 6/26/1981 | RDG | Stapleton | Traded away | RIN | | After |
| 6/26/1981 | RDG | Stapleton | Acquired via trade | HAM | | After |
| 6/26/1981 | RIN | Nettles,G | Traded away | RDG | | After |
| 6/26/1981 | RIN | Stapleton | Acquired via trade | RDG | | After |
| 6/27/1981 | RDG | Boggs | Promoted to active roster | | | Before |
| 6/27/1981 | RDG | Capilla | Promoted to active roster | | | Before |
| 6/27/1981 | RDG | Erickson | Demoted to reserve roster | | | Before |
| 6/27/1981 | RDG | Foote | Demoted to reserve roster | | | Before |
| 6/27/1981 | RDG | Hanna | Promoted to active roster | | | Before |
| 6/27/1981 | RDG | Leibrandt | Demoted to reserve roster | | | Before |
| 6/27/1981 | RDG | Miller,D | Promoted to active roster | | | Before |
| 6/27/1981 | RDG | Mura | Promoted to active roster | | | Before |
| 6/27/1981 | RDG | Nettles,G | Promoted to active roster | | | Before |
| 6/27/1981 | RDG | Quirk | Promoted to active roster | | | Before |
| 6/27/1981 | RDG | Waits | Promoted to active roster | | | Before |
| 6/27/1981 | RDG | Wallach | Demoted to reserve roster | | | Before |
| 6/27/1981 | RDG | Wiggins | Demoted to reserve roster | | | Before |
| 6/27/1981 | RIN | Pittman | Demoted to reserve roster | | | Before |
| 6/27/1981 | RIN | Stapleton | Promoted to active roster | | | Before |
| 7/1/1981 | SOP | Bando,C | Demoted to reserve roster | | | Before |
| 7/1/1981 | SOP | Ferguson | Promoted to active roster | | | Before |
| 7/3/1981 | PAK | Leonard | Promoted to active roster | | | Before |
| 7/3/1981 | PAK | Oester | Placed on Injured List | | 7/2/1981 | Before |
| 7/4/1981 | HNT | Schmidt,DJ | Promoted to active roster | | | Before |
| 7/4/1981 | HNT | Stewart,D | Demoted to reserve roster | | | Before |
| 7/4/1981 | PAK | Beniquez | Promoted to active roster | | | Before |
| 7/4/1981 | PAK | Leonard | Demoted to reserve roster | | | Before |
| 7/4/1981 | RIN | Lefebvre | Activated from Injured List | | | Before |
| 7/4/1981 | RIN | Youngblood | Demoted to reserve roster | | | Before |
| 7/5/1981 | AVI | Law,V | Promoted to active roster | | | Before |
| 7/5/1981 | AVI | Wynegar | Demoted to reserve roster | | | Before |
| 7/5/1981 | QME | Caudill | Demoted to reserve roster | | | Before |
| 7/5/1981 | QME | Reuss | Activated from Injured List | | | Before |
| 7/6/1981 | AVI | Brookens | Demoted to reserve roster | | | Before |
| 7/6/1981 | AVI | Salazar | Promoted to active roster | | | Before |
| 7/6/1981 | RIN | Davis,D | Placed on Injured List | | 7/6/1981 | Before |
| 7/6/1981 | RIN | Hurdle | Promoted to active roster | | | Before |
| 7/10/1981 | ROC | Johnson,C | Activated from Injured List | | | Before |
| 7/10/1981 | ROC | Parrish,Lr | Demoted to reserve roster | | | Before |
| 7/11/1981 | ROC | Orta | Promoted to active roster | | | Before |
| 7/11/1981 | ROC | Thomas,G | Placed on Injured List | | 7/11/1981 | Before |
| 7/12/1981 | AVI | Burgmeier | Demoted to reserve roster | | | Before |
| 7/12/1981 | AVI | Candelaria | Promoted to active roster | | | Before |
| 7/12/1981 | QME | Howe,S | Acquired via trade | RDG | | After |
| 7/12/1981 | QME | Morgan | Acquired via trade | RDG | | After |
| 7/12/1981 | RDG | Howe,S | Traded away | QME | | After |
| 7/12/1981 | RDG | Morgan | Traded away | QME | | After |
| 7/12/1981 | RIN | Hrabosky | Promoted to active roster | | | Before |
| 7/12/1981 | RIN | Lucas | Demoted to reserve roster | | | Before |
| 7/12/1981 | ROC | Aguayo | Demoted to reserve roster | | | Before |
| 7/12/1981 | ROC | Fischlin | Promoted to active roster | | | Before |
| 7/13/1981 | AVI | Martinez,T | Placed on Injured List | | 7/13/1981 | Before |
| 7/13/1981 | AVI | Rucker | Promoted to active roster | | | Before |
| 7/13/1981 | QME | Parrott | Demoted to reserve roster | | | Before |
| 7/13/1981 | QME | Randle | Demoted to reserve roster | | | Before |
| 7/13/1981 | RDG | Farmer | Promoted to active roster | | | Before |
| 7/13/1981 | RDG | Gross,G | Promoted to active roster | | | Before |
| 7/14/1981 | RIN | Butcher | Promoted to active roster | | | Before |
| 7/14/1981 | RIN | Grote | Promoted to active roster | | | Before |
| 7/14/1981 | RIN | Grubb | Demoted to reserve roster | | | Before |
| 7/14/1981 | RIN | Krukow | Demoted to reserve roster | | | Before |
| 7/14/1981 | RIN | May,M | Demoted to reserve roster | | | Before |
| 7/14/1981 | RIN | Youngblood | Promoted to active roster | | | Before |
| 7/14/1981 | ROC | Krenchicki | Demoted to reserve roster | | | Before |
| 7/14/1981 | ROC | Krenchicki | Promoted to active roster | | | Before |
| 7/14/1981 | ROC | Krenchicki | Promoted to active roster | | | Before |
| 7/14/1981 | ROC | Landrum | Demoted to reserve roster | | | Before |
| 7/14/1981 | ROC | Parrish,Lr | Promoted to active roster | | | Before |
| 7/14/1981 | ROC | Yount | Placed on Injured List | | 7/14/1981 | Before |
| 7/15/1981 | RIN | Butcher | Demoted to reserve roster | | | Before |
| 7/15/1981 | RIN | Krukow | Promoted to active roster | | | Before |
| 7/16/1981 | PAK | Forster | Demoted to reserve roster | | | Before |
| 7/16/1981 | PAK | Tyson | Signed | | | Before |
| 7/16/1981 | RIN | Grubb | Promoted to active roster | | | Before |
| 7/16/1981 | RIN | Hrabosky | Demoted to reserve roster | | | Before |
| 7/16/1981 | RIN | Stein,B | Promoted to active roster | | | Before |
| 7/16/1981 | RIN | Youngblood | Placed on Injured List | | 7/16/1981 | Before |
| 7/18/1981 | PAK | Beniquez | Demoted to reserve roster | | | Before |
| 7/18/1981 | PAK | Hobson | Demoted to reserve roster | | | Before |
| 7/18/1981 | PAK | Hobson | Promoted to active roster | | | Before |
| 7/18/1981 | PAK | Oester | Activated from Injured List | | | Before |
| 7/18/1981 | PAK | Putnam | Activated from Injured List | | | Before |
| 7/18/1981 | PAK | Tyson | Demoted to reserve roster | | | Before |
| 7/18/1981 | SOP | Belanger | Demoted to reserve roster | | | Before |
| 7/20/1981 | RIN | Grote | Demoted to reserve roster | | | Before |
| 7/20/1981 | RIN | Laudner | Promoted to active roster | | | Before |
| 7/21/1981 | RIN | Davis,D | Activated from Injured List | | | Before |
| 7/21/1981 | RIN | Hurdle | Demoted to reserve roster | | | Before |
| 7/21/1981 | RIN | Lucas | Promoted to active roster | | | Before |
| 7/21/1981 | RIN | Stapleton | Demoted to reserve roster | | | Before |
| 7/24/1981 | RDG | Capilla | Demoted to reserve roster | | | Before |
| 7/24/1981 | RDG | Erickson | Promoted to active roster | | | Before |
| 7/24/1981 | RDG | Foote | Promoted to active roster | | | Before |
| 7/24/1981 | RDG | Griffin,A | Promoted to active roster | | | Before |
| 7/24/1981 | RDG | Miller,D | Demoted to reserve roster | | | Before |
| 7/24/1981 | RDG | Show | Promoted to active roster | | | Before |
| 7/25/1981 | RDG | Mura | Demoted to reserve roster | | | Before |
| 7/25/1981 | RDG | Show | Demoted to reserve roster | | | Before |
| 7/25/1981 | RIN | Grubb | Demoted to reserve roster | | | Before |
| 7/25/1981 | RIN | Rincon | Activated from Injured List | | | Before |
| 7/26/1981 | RDG | Flanagan | Demoted to reserve roster | | | Before |
| 7/26/1981 | RDG | Foote | Demoted to reserve roster | | | Before |
| 7/26/1981 | RDG | Hanna | Demoted to reserve roster | | | Before |
| 7/26/1981 | RDG | Leibrandt | Promoted to active roster | | | Before |
| 7/26/1981 | RDG | Mura | Promoted to active roster | | | Before |
| 7/26/1981 | RDG | Nelson | Demoted to reserve roster | | | Before |
| 7/26/1981 | RDG | Nelson | Promoted to active roster | | | Before |
| 7/26/1981 | RDG | Russell | Demoted to reserve roster | | | Before |
| 7/26/1981 | RDG | Sax | Demoted to reserve roster | | | Before |
| 7/26/1981 | RDG | Show | Promoted to active roster | | | Before |
| 7/26/1981 | RDG | Wallach | Promoted to active roster | | | Before |
| 7/26/1981 | RDG | Wilfong | Promoted to active roster | | | Before |
| 7/26/1981 | ROC | Garcia,Dam | Promoted to active roster | | | Before |
| 7/26/1981 | ROC | Krenchicki | Demoted to reserve roster | | | Before |
| 7/26/1981 | ROC | Landrum | Promoted to active roster | | | Before |
| 7/26/1981 | ROC | Orta | Demoted to reserve roster | | | Before |
| 7/26/1981 | ROC | Thomas,G | Activated from Injured List | | | Before |
| 7/26/1981 | ROC | Thon | Demoted to reserve roster | | | Before |
| 7/27/1981 | SOP | Jacoby | Demoted to reserve roster | | | Before |
| 7/27/1981 | SOP | Parker | Activated from Injured List | | | Before |
| 7/27/1981 | SOP | Vukovich,G | Promoted to active roster | | | Before |
| 7/27/1981 | SOP | Walling | Placed on Injured List | | 7/27/1981 | Before |
| 7/28/1981 | AVI | Martinez,T | Activated from Injured List | | | Before |
| 7/28/1981 | AVI | Rucker | Demoted to reserve roster | | | Before |
| 7/30/1981 | HNT | Stewart,S | Traded away | OKI | | After |
| 7/30/1981 | ROC | Parrish,Lr | Demoted to reserve roster | | | Before |
| 7/30/1981 | ROC | Yount | Activated from Injured List | | | Before |
| 7/31/1981 | HNT | Picciolo | Demoted to reserve roster | | | Before |
| 7/31/1981 | HNT | Picciolo | Promoted to active roster | | | Before |
| 7/31/1981 | HNT | Reed,R | Promoted to active roster | | | Before |
| 7/31/1981 | HNT | Roberts,L | Promoted to active roster | | | Before |
| 7/31/1981 | HNT | Rose | Demoted to reserve roster | | | Before |
| 7/31/1981 | HNT | Rose | Promoted to active roster | | | Before |
| 7/31/1981 | HNT | Manning | Traded away | RIN | | After |
| 7/31/1981 | HNT | Reed,R | Acquired via trade | RIN | | After |
| 7/31/1981 | PAK | Nolan | Demoted to reserve roster | | | Before |
| 7/31/1981 | PAK | Tyson | Promoted to active roster | | | Before |
| 7/31/1981 | QME | Stone | Traded away | AND | | After |
| 7/31/1981 | RIN | Manning | Demoted to reserve roster | | | Before |
| 7/31/1981 | RIN | Wilson,M | Placed on Injured List | | 7/31/1981 | Before |
| 7/31/1981 | RIN | Youngblood | Activated from Injured List | | | Before |
| 7/31/1981 | RIN | Manning | Acquired via trade | HNT | | After |
| 7/31/1981 | RIN | Peters | Acquired via trade | SOP | | After |
| 7/31/1981 | RIN | Reed,R | Traded away | HNT | | After |
| 7/31/1981 | SOP | Peters | Traded away | RIN | | After |
| 8/1/1981 | PAK | Easterly | Demoted to reserve roster | | | Before |
| 8/1/1981 | PAK | Forster | Promoted to active roster | | | Before |
| 8/1/1981 | RIN | Grubb | Promoted to active roster | | | Before |
| 8/1/1981 | RIN | Stein,B | Demoted to reserve roster | | | Before |
| 8/1/1981 | RIN | Stein,B | Promoted to active roster | | | Before |
| 8/1/1981 | RIN | Zisk | Demoted to reserve roster | | | Before |
| 8/1/1981 | SOP | Brusstar | Promoted to active roster | | | Before |
| 8/1/1981 | SOP | North | Promoted to active roster | | | Before |
| 8/1/1981 | SOP | Reardon | Demoted to reserve roster | | | Before |
| 8/3/1981 | AVI | Cabell | Promoted to active roster | | | Before |
| 8/3/1981 | AVI | Lowenstein | Demoted to reserve roster | | | Before |
| 8/3/1981 | RDG | Foote | Demoted to reserve roster | | | Before |
| 8/3/1981 | RDG | Foote | Promoted to active roster | | | Before |
| 8/3/1981 | RDG | Nettles,G | Placed on Injured List | | 8/3/1981 | Before |
| 8/3/1981 | RDG | Russell | Promoted to active roster | | | Before |
| 8/3/1981 | ROC | Armstrong | Promoted to active roster | | | Before |
| 8/3/1981 | ROC | Wilcox | Demoted to reserve roster | | | Before |
| 8/4/1981 | QME | Hodges | Promoted to active roster | | | Before |
| 8/4/1981 | QME | Lacy | Demoted to reserve roster | | | Before |
| 8/4/1981 | RDG | Leibrandt | Demoted to reserve roster | | | Before |
| 8/5/1981 | AVI | Andujar | Placed on Injured List | | 8/5/1981 | Before |
| 8/5/1981 | AVI | Stanton | Promoted to active roster | | | Before |
| 8/5/1981 | QME | Randle | Promoted to active roster | | | Before |
| 8/5/1981 | QME | Washington,UL | Placed on Injured List | | 8/4/1981 | Before |
| 8/5/1981 | RIN | Phelps | Promoted to active roster | | | Before |
| 8/5/1981 | RIN | Rincon | Demoted to reserve roster | | | Before |
| 8/7/1981 | AVI | Babitt | Promoted to active roster | | | Before |
| 8/7/1981 | AVI | Henderson,D | Demoted to reserve roster | | | Before |
| 8/8/1981 | RDG | Hanna | Promoted to active roster | | | Before |
| 8/8/1981 | RDG | Miller,D | Promoted to active roster | | | Before |
| 8/8/1981 | RDG | Show | Demoted to reserve roster | | | Before |
| 8/10/1981 | PAK | DeJesus | Demoted to reserve roster | | | Before |
| 8/10/1981 | PAK | Leonard | Promoted to active roster | | | Before |
| 8/11/1981 | ROC | Leal | Demoted to reserve roster | | | Before |
| 8/11/1981 | ROC | Spillner | Promoted to active roster | | | Before |
| 8/13/1981 | AVI | Iorg,G | Promoted to active roster | | | Before |
| 8/13/1981 | AVI | Kison | Demoted to reserve roster | | | Before |
| 8/13/1981 | SOP | Darwin | Placed on Injured List | | 8/12/1981 | Before |
| 8/13/1981 | SOP | Rowland | Promoted to active roster | | | Before |
| 8/14/1981 | PAK | Easterly | Promoted to active roster | | | Before |
| 8/14/1981 | PAK | Honeycutt | Demoted to reserve roster | | | Before |
| 8/14/1981 | ROC | Swan | Promoted to active roster | | | Before |
| 8/14/1981 | ROC | Whitson | Demoted to reserve roster | | | Before |
| 8/15/1981 | RDG | Flanagan | Promoted to active roster | | | Before |
| 8/15/1981 | RDG | Goltz | Placed on Injured List | | 8/15/1981 | Before |
| 8/16/1981 | RDG | Capilla | Promoted to active roster | | | Before |
| 8/16/1981 | RDG | Erickson | Demoted to reserve roster | | | Before |
| 8/16/1981 | SOP | McGaffigan | Promoted to active roster | | | Before |
| 8/16/1981 | SOP | Rowland | Demoted to reserve roster | | | Before |
| 8/17/1981 | QME | Arroyo | Promoted to active roster | | | Before |
| 8/17/1981 | QME | Bannister,F | Demoted to reserve roster | | | Before |
| 8/17/1981 | QME | Clancy | Demoted to reserve roster | | | Before |
| 8/17/1981 | QME | Parrott | Promoted to active roster | | | Before |
| 8/17/1981 | ROC | Armstrong | Demoted to reserve roster | | | Before |
| 8/17/1981 | ROC | Moffitt | Promoted to active roster | | | Before |
| 8/19/1981 | HNT | Carew | Placed on Injured List | | 8/18/1981 | Before |
| 8/19/1981 | HNT | Gedman | Demoted to reserve roster | | | Before |
| 8/19/1981 | HNT | Rose | Promoted to active roster | | | Before |
| 8/19/1981 | HNT | Schmidt,DF | Promoted to active roster | | | Before |
| 8/20/1981 | AVI | Andujar | Activated from Injured List | | | Before |
| 8/20/1981 | AVI | Petry | Demoted to reserve roster | | | Before |
| 8/20/1981 | PAK | DeJesus | Promoted to active roster | | | Before |
| 8/20/1981 | PAK | Sorensen | Demoted to reserve roster | | | Before |
| 8/20/1981 | SOP | Parker | Placed on Injured List | | 8/20/1981 | Before |
| 8/20/1981 | SOP | Walling | Activated from Injured List | | | Before |
| 8/21/1981 | QME | Randle | Demoted to reserve roster | | | Before |
| 8/21/1981 | QME | Washington,UL | Activated from Injured List | | | Before |
| 8/21/1981 | ROC | Swan | Demoted to reserve roster | | | Before |
| 8/21/1981 | ROC | Wilcox | Promoted to active roster | | | Before |
| 8/22/1981 | ROC | Garcia,Dam | Demoted to reserve roster | | | Before |
| 8/22/1981 | ROC | Trevino | Promoted to active roster | | | Before |
| 8/23/1981 | RDG | Foote | Promoted to active roster | | | Before |
| 8/23/1981 | RDG | Hebner | Promoted to active roster | | | Before |
| 8/23/1981 | RDG | Miller,E | Promoted to active roster | | | Before |
| 8/23/1981 | RDG | Nelson | Demoted to reserve roster | | | Before |
| 8/23/1981 | RDG | Quirk | Demoted to reserve roster | | | Before |
| 8/23/1981 | RDG | Wallach | Demoted to reserve roster | | | Before |
| 8/23/1981 | RIN | Saucier | Promoted to active roster | | | Before |
| 8/23/1981 | RIN | Vuckovich | Demoted to reserve roster | | | Before |
| 8/23/1981 | SOP | Gorman | Promoted to active roster | | | Before |
| 8/23/1981 | SOP | Price | Demoted to reserve roster | | | Before |
| 8/24/1981 | HNT | Schmidt,DJ | Demoted to reserve roster | | | Before |
| 8/24/1981 | HNT | Urrea | Promoted to active roster | | | Before |
| 8/25/1981 | RIN | Phelps | Demoted to reserve roster | | | Before |
| 8/25/1981 | RIN | Stapleton | Promoted to active roster | | | Before |
| 8/25/1981 | SOP | Beard | Promoted to active roster | | | Before |
| 8/25/1981 | SOP | Vukovich,G | Demoted to reserve roster | | | Before |
| 8/26/1981 | QME | Corcoran | Demoted to reserve roster | | | Before |
| 8/26/1981 | QME | Ford,Dan | Promoted to active roster | | | Before |
| 8/26/1981 | ROC | Fischlin | Demoted to reserve roster | | | Before |
| 8/26/1981 | ROC | Krenchicki | Promoted to active roster | | | Before |
| 8/29/1981 | AVI | Moreland | Demoted to reserve roster | | | Before |
| 8/29/1981 | AVI | Yeager | Promoted to active roster | | | Before |
| 8/30/1981 | RDG | Flanagan | Demoted to reserve roster | | | Before |
| 8/30/1981 | RDG | Goltz | Activated from Injured List | | | Before |
| 9/1/1981 | AVI | Bergman | Promoted to active roster | | | Before |
| 9/1/1981 | AVI | Brookens | Promoted to active roster | | | Before |
| 9/1/1981 | AVI | Henderson,D | Promoted to active roster | | | Before |
| 9/1/1981 | AVI | Petry | Promoted to active roster | | | Before |
| 9/1/1981 | AVI | Stanton | Demoted to reserve roster | | | Before |
| 9/1/1981 | PAK | Beniquez | Promoted to active roster | | | Before |
| 9/1/1981 | PAK | O'Berry | Promoted to active roster | | | Before |
| 9/1/1981 | QME | Bannister,F | Promoted to active roster | | | Before |
| 9/1/1981 | QME | Caudill | Promoted to active roster | | | Before |
| 9/1/1981 | QME | Clancy | Promoted to active roster | | | Before |
| 9/1/1981 | QME | Flynn | Promoted to active roster | | | Before |
| 9/1/1981 | QME | Ivie | Promoted to active roster | | | Before |
| 9/1/1981 | QME | Kuiper | Promoted to active roster | | | Before |
| 9/1/1981 | QME | Lacy | Promoted to active roster | | | Before |
| 9/1/1981 | QME | McGraw | Promoted to active roster | | | Before |
| 9/1/1981 | QME | Randle | Promoted to active roster | | | Before |
| 9/1/1981 | QME | Smith,Lo | Promoted to active roster | | | Before |
| 9/1/1981 | RDG | Nettles,G | Activated from Injured List | | | Before |
| 9/1/1981 | RDG | Quirk | Promoted to active roster | | | Before |
| 9/1/1981 | RDG | Russell | Demoted to reserve roster | | | Before |
| 9/1/1981 | RIN | Hrabosky | Promoted to active roster | | | Before |
| 9/1/1981 | RIN | Hurdle | Promoted to active roster | | | Before |
| 9/1/1981 | RIN | Manning | Promoted to active roster | | | Before |
| 9/1/1981 | RIN | May,M | Promoted to active roster | | | Before |
| 9/1/1981 | RIN | McLaughlin,J | Promoted to active roster | | | Before |
| 9/1/1981 | RIN | Peters | Promoted to active roster | | | Before |
| 9/1/1981 | RIN | Rozema | Promoted to active roster | | | Before |
| 9/1/1981 | RIN | Youngblood | Demoted to reserve roster | | | Before |
| 9/2/1981 | RIN | Wilson,M | Activated from Injured List | | | Before |
| 9/4/1981 | SOP | McGaffigan | Demoted to reserve roster | | | Before |
| 9/4/1981 | SOP | Parker | Activated from Injured List | | | Before |
| 9/5/1981 | RIN | Allen,N | Promoted to active roster | | | Before |
| 9/5/1981 | RIN | Davis,D | Demoted to reserve roster | | | Before |
| 9/5/1981 | RIN | Saucier | Demoted to reserve roster | | | Before |
| 9/5/1981 | RIN | Zisk | Promoted to active roster | | | Before |
| 9/7/1981 | RIN | Wilson,M | Activated from Injured List | | | Before |
| 9/9/1981 | ROC | Blue | Demoted to reserve roster | | | Before |
| 9/9/1981 | ROC | Lee,B | Promoted to active roster | | | Before |
| 9/11/1981 | ROC | Guidry | Demoted to reserve roster | | | Before |
| 9/11/1981 | ROC | Leal | Promoted to active roster | | | Before |
| 9/13/1981 | PAK | Nolan | Promoted to active roster | | | Before |
| 9/13/1981 | QME | Tenace | Demoted to reserve roster | | | Before |
| 9/13/1981 | ROC | Alexander,M | Promoted to active roster | | | Before |
| 9/13/1981 | ROC | Geronimo | Promoted to active roster | | | Before |
| 9/13/1981 | ROC | Koosman | Promoted to active roster | | | Before |
| 9/13/1981 | ROC | Orta | Promoted to active roster | | | Before |
| 9/13/1981 | ROC | Virgil | Promoted to active roster | | | Before |
| 9/13/1981 | ROC | Whitson | Promoted to active roster | | | Before |
| 9/14/1981 | SOP | Backman | Promoted to active roster | | | Before |
| 9/14/1981 | SOP | Tabler | Demoted to reserve roster | | | Before |
| 9/15/1981 | ROC | Stargell | Promoted to active roster | | | Before |
| 9/17/1981 | RIN | Rincon | Demoted to reserve roster | | | Before |
| 9/17/1981 | RIN | Vuckovich | Promoted to active roster | | | Before |
| 9/18/1981 | RIN | Cruz,H | Promoted to active roster | | | Before |
| 9/18/1981 | RIN | Krukow | Demoted to reserve roster | | | Before |
| 9/18/1981 | RIN | McCatty | Demoted to reserve roster | | | Before |
| 9/18/1981 | RIN | Paciorek | Demoted to reserve roster | | | Before |
| 9/19/1981 | SOP | Campaneris | Promoted to active roster | | | Before |
| 9/19/1981 | SOP | Reitz | Demoted to reserve roster | | | Before |
| 9/20/1981 | QME | Tenace | Promoted to active roster | | | Before |
| 9/21/1981 | ROC | Virgil | Demoted to reserve roster | | | Before |
| 9/21/1981 | SOP | Bando,C | Promoted to active roster | | | Before |
| 9/21/1981 | SOP | Brusstar | Demoted to reserve roster | | | Before |
| 9/24/1981 | HNT | Abbott | Demoted to reserve roster | | | Before |
| 9/24/1981 | HNT | Allard | Promoted to active roster | | | Before |
| 9/24/1981 | HNT | Berenguer | Promoted to active roster | | | Before |
| 9/24/1981 | HNT | Trout | Demoted to reserve roster | | | Before |
| 9/24/1981 | PAK | Honeycutt | Promoted to active roster | | | Before |
| 9/24/1981 | PAK | Sorensen | Promoted to active roster | | | Before |
| 9/27/1981 | ROC | Leal | Demoted to reserve roster | | | Before |
| 9/27/1981 | ROC | Wilcox | Demoted to reserve roster | | | Before |