| Transactions |
| Date | Team | Player | Type | OthTm | EffDate | When |
| 4/6/2015 | CAR | Butera | Demoted to reserve roster | | | Before |
| 4/8/2015 | TEW | Descalso | Promoted to active roster | | | Before |
| 4/8/2015 | TEW | Mercer | Placed on Injured List | | 4/7/2015 | Before |
| 4/11/2015 | SOI | McGehee | Promoted to active roster | | | Before |
| 4/11/2015 | SOI | Wong | Placed on Injured List | | 4/11/2015 | Before |
| 4/12/2015 | BRK | Petit,Y | Promoted to active roster | | | Before |
| 4/12/2015 | BRK | Ray | Placed on Injured List | | 4/12/2015 | Before |
| 4/12/2015 | CEN | Blevins | Promoted to active roster | | | Before |
| 4/12/2015 | CEN | Guerra,Ju | Demoted to reserve roster | | | Before |
| 4/14/2015 | RMO | Beckham,G | Promoted to active roster | | | Before |
| 4/14/2015 | RMO | Gallo | Placed on Injured List | | 4/13/2015 | Before |
| 4/16/2015 | NEP | Givens | Placed on Injured List | | 4/16/2015 | Before |
| 4/16/2015 | NEP | Morales,F | Promoted to active roster | | | Before |
| 4/18/2015 | CIO | Casali | Promoted to active roster | | | Before |
| 4/18/2015 | CIO | Montero,M | Placed on Injured List | | 4/17/2015 | Before |
| 4/18/2015 | NEP | Jackson,E | Promoted to active roster | | | Before |
| 4/18/2015 | NEP | Quintana | Placed on Injured List | | 4/18/2015 | Before |
| 4/20/2015 | CSS | Alexander | Demoted to reserve roster | | | Before |
| 4/20/2015 | CSS | Torres,C | Promoted to active roster | | | Before |
| 4/20/2015 | HAR | Grandal | Placed on Injured List | | 4/20/2015 | Before |
| 4/20/2015 | HAR | Navarro,D | Promoted to active roster | | | Before |
| 4/21/2015 | CAR | Johnson,C | Promoted to active roster | | | Before |
| 4/21/2015 | CAR | Ross,J | Demoted to reserve roster | | | Before |
| 4/21/2015 | NEP | Guyer | Demoted to reserve roster | | | Before |
| 4/21/2015 | NEP | Matz | Promoted to active roster | | | Before |
| 4/21/2015 | RMO | Kepler | Demoted to reserve roster | | | Before |
| 4/21/2015 | RMO | Utley | Promoted to active roster | | | Before |
| 4/22/2015 | TEW | Garza | Placed on Injured List | | 4/22/2015 | Before |
| 4/22/2015 | TEW | Wainwright | Promoted to active roster | | | Before |
| 4/23/2015 | RMO | Callaspo | Promoted to active roster | | | Before |
| 4/23/2015 | RMO | Gardner | Placed on Injured List | | 4/22/2015 | Before |
| 4/24/2015 | CSS | Dull | Demoted to reserve roster | | | Before |
| 4/24/2015 | CSS | Jeffress | Promoted to active roster | | | Before |
| 4/24/2015 | FDH | Doolittle | Demoted to reserve roster | | | Before |
| 4/24/2015 | FDH | Rodriguez,Fe | Promoted to active roster | | | Before |
| 4/24/2015 | TEW | Colome | Placed on Injured List | | 4/24/2015 | Before |
| 4/24/2015 | TEW | Vincent | Promoted to active roster | | | Before |
| 4/25/2015 | CEN | Bedrosian | Placed on Injured List | | 4/25/2015 | Before |
| 4/25/2015 | CEN | Blevins | Demoted to reserve roster | | | Before |
| 4/25/2015 | CEN | Dickey | Promoted to active roster | | | Before |
| 4/25/2015 | CEN | Luetge | Promoted to active roster | | | Before |
| 4/26/2015 | CEN | Jennings,Da | Promoted to active roster | | | Before |
| 4/26/2015 | CEN | Luetge | Demoted to reserve roster | | | Before |
| 4/26/2015 | CSS | Johnson,J | Promoted to active roster | | | Before |
| 4/26/2015 | CSS | Reed,A | Placed on Injured List | | 4/24/2015 | Before |
| 4/26/2015 | HAR | Pearce | Promoted to active roster | | | Before |
| 4/26/2015 | HAR | Wright,D | Placed on Injured List | | 4/26/2015 | Before |
| 4/28/2015 | BRK | Aviles | Promoted to active roster | | | Before |
| 4/28/2015 | BRK | Correa | Demoted to reserve roster | | | Before |
| 4/28/2015 | BRK | Hamilton,B | Promoted to active roster | | | Before |
| 4/28/2015 | BRK | Hedges | Promoted to active roster | | | Before |
| 4/28/2015 | BRK | Iannetta | Demoted to reserve roster | | | Before |
| 4/28/2015 | BRK | Infante | Promoted to active roster | | | Before |
| 4/28/2015 | BRK | Joyce | Placed on Injured List | | 4/27/2015 | Before |
| 4/28/2015 | BRK | Kendrick,K | Promoted to active roster | | | Before |
| 4/28/2015 | BRK | Osuna | Demoted to reserve roster | | | Before |
| 4/28/2015 | BRK | Paxton | Demoted to reserve roster | | | Before |
| 4/28/2015 | BRK | Ray | Activated from Injured List | | | Before |
| 4/28/2015 | BRK | Smoak | Demoted to reserve roster | | | Before |
| 4/28/2015 | BRK | Stanton | Demoted to reserve roster | | | Before |
| 4/28/2015 | BRK | Yates | Promoted to active roster | | | Before |
| 4/28/2015 | GAR | Dickerson,C | Placed on Injured List | | 4/27/2015 | Before |
| 4/28/2015 | GAR | Robinson,C | Promoted to active roster | | | Before |
| 4/29/2015 | CIN | Drury | Promoted to active roster | | | Before |
| 4/29/2015 | CIN | Iglesias,J | Placed on Injured List | | 4/29/2015 | Before |
| 4/29/2015 | GAR | Herrera,O | Placed on Injured List | | 4/29/2015 | Before |
| 4/29/2015 | GAR | Shuck | Promoted to active roster | | | Before |
| 4/29/2015 | SOI | McGehee | Demoted to reserve roster | | | Before |
| 4/29/2015 | SOI | Wong | Activated from Injured List | | | Before |
| 4/30/2015 | CIO | Casali | Placed on Injured List | | 4/30/2015 | Before |
| 4/30/2015 | CIO | Murphy,J | Promoted to active roster | | | Before |
| 4/30/2015 | NEP | Colabello | Promoted to active roster | | | Before |
| 4/30/2015 | NEP | Conforto | Demoted to reserve roster | | | Before |
| 4/30/2015 | NEP | Miller,B | Promoted to active roster | | | Before |
| 4/30/2015 | NEP | Ruf | Demoted to reserve roster | | | Before |
| 5/1/2015 | NEP | Fields,J | Demoted to reserve roster | | | Before |
| 5/1/2015 | NEP | Givens | Activated from Injured List | | | Before |
| 5/1/2015 | NEP | Ruf | Promoted to active roster | | | Before |
| 5/1/2015 | NEP | Ruggiano | Demoted to reserve roster | | | Before |
| 5/2/2015 | CIO | Montero,M | Activated from Injured List | | | Before |
| 5/2/2015 | CIO | Murphy,J | Demoted to reserve roster | | | Before |
| 5/3/2015 | CSS | Broxton,J | Promoted to active roster | | | Before |
| 5/3/2015 | CSS | Sabathia | Promoted to active roster | | | Before |
| 5/3/2015 | CSS | Thornburg | Demoted to reserve roster | | | Before |
| 5/3/2015 | CSS | Wood,A | Placed on Injured List | | 5/3/2015 | Before |
| 5/3/2015 | GAR | Duffey | Promoted to active roster | | | Before |
| 5/3/2015 | GAR | Pineda | Demoted to reserve roster | | | Before |
| 5/3/2015 | NEP | Matz | Demoted to reserve roster | | | Before |
| 5/3/2015 | NEP | Quintana | Activated from Injured List | | | Before |
| 5/4/2015 | GAR | Buehrle | Promoted to active roster | | | Before |
| 5/4/2015 | GAR | Jepsen | Promoted to active roster | | | Before |
| 5/4/2015 | GAR | McGee | Promoted to active roster | | | Before |
| 5/4/2015 | GAR | Siegrist | Demoted to reserve roster | | | Before |
| 5/4/2015 | GAR | Street | Demoted to reserve roster | | | Before |
| 5/4/2015 | GAR | Volquez | Demoted to reserve roster | | | Before |
| 5/5/2015 | RMO | Beckham,G | Demoted to reserve roster | | | Before |
| 5/5/2015 | RMO | Beckham,G | Promoted to active roster | | | Before |
| 5/5/2015 | RMO | Callaspo | Demoted to reserve roster | | | Before |
| 5/5/2015 | RMO | Gallo | Activated from Injured List | | | Before |
| 5/5/2015 | TEW | Chacin | Promoted to active roster | | | Before |
| 5/5/2015 | TEW | Foltynewicz | Placed on Injured List | | 5/5/2015 | Before |
| 5/6/2015 | ANN | Leake | Placed on Injured List | | 5/5/2015 | Before |
| 5/6/2015 | ANN | Nuno | Promoted to active roster | | | Before |
| 5/7/2015 | CEN | Galvis | Promoted to active roster | | | Before |
| 5/7/2015 | CEN | Villar | Demoted to reserve roster | | | Before |
| 5/7/2015 | HHR | Holliday | Placed on Injured List | | 5/6/2015 | Before |
| 5/7/2015 | NYD | Bird | Promoted to active roster | | | Before |
| 5/7/2015 | NYD | Byrd | Promoted to active roster | | | Before |
| 5/7/2015 | NYD | Wallace | Demoted to reserve roster | | | Before |
| 5/7/2015 | NYD | Yelich | Placed on Injured List | | 5/7/2015 | Before |
| 5/7/2015 | RMO | Beckham,G | Demoted to reserve roster | | | Before |
| 5/7/2015 | RMO | Gardner | Activated from Injured List | | | Before |
| 5/8/2015 | HHR | Polanco,G | Promoted to active roster | | | Before |
| 5/9/2015 | CIN | Araujo | Promoted to active roster | | | Before |
| 5/9/2015 | CIN | Gilmartin | Demoted to reserve roster | | | Before |
| 5/9/2015 | CIN | Goeddel | Demoted to reserve roster | | | Before |
| 5/9/2015 | CIN | Hoover | Promoted to active roster | | | Before |
| 5/9/2015 | CIN | Miller,A | Demoted to reserve roster | | | Before |
| 5/9/2015 | CIN | Ramos,C | Promoted to active roster | | | Before |
| 5/9/2015 | CIN | Socolovich | Promoted to active roster | | | Before |
| 5/9/2015 | CIN | Wilhelmsen | Demoted to reserve roster | | | Before |
| 5/9/2015 | NEP | Conforto | Promoted to active roster | | | Before |
| 5/9/2015 | NEP | Ethier | Placed on Injured List | | 5/8/2015 | Before |
| 5/9/2015 | RMO | Davies,Z | Demoted to reserve roster | | | Before |
| 5/9/2015 | RMO | Eovaldi | Promoted to active roster | | | Before |
| 5/10/2015 | CIO | Gutierrez | Promoted to active roster | | | Before |
| 5/10/2015 | CIO | Thompson,T | Demoted to reserve roster | | | Before |
| 5/10/2015 | CSS | Broxton,J | Demoted to reserve roster | | | Before |
| 5/10/2015 | CSS | Reed,A | Activated from Injured List | | | Before |
| 5/10/2015 | NEP | Fields,J | Promoted to active roster | | | Before |
| 5/10/2015 | NEP | Kelley | Demoted to reserve roster | | | Before |
| 5/11/2015 | HHR | Iwakuma | Placed on Injured List | | 5/9/2015 | Before |
| 5/11/2015 | RMO | Muncy | Demoted to reserve roster | | | Before |
| 5/11/2015 | RMO | Tillman | Promoted to active roster | | | Before |
| 5/13/2015 | CAR | Boxberger | Promoted to active roster | | | Before |
| 5/13/2015 | CAR | Pence | Demoted to reserve roster | | | Before |
| 5/13/2015 | GAR | Dickerson,C | Activated from Injured List | | | Before |
| 5/13/2015 | GAR | Robinson,C | Demoted to reserve roster | | | Before |
| 5/14/2015 | BRK | Baez,J | Promoted to active roster | | | Before |
| 5/14/2015 | BRK | Hamilton,B | Demoted to reserve roster | | | Before |
| 5/14/2015 | BRK | Hardy,J | Placed on Injured List | | 5/14/2015 | Before |
| 5/14/2015 | BRK | Joyce | Activated from Injured List | | | Before |
| 5/14/2015 | BRK | Knebel | Promoted to active roster | | | Before |
| 5/14/2015 | BRK | Rivero | Demoted to reserve roster | | | Before |
| 5/14/2015 | CIN | Drury | Demoted to reserve roster | | | Before |
| 5/14/2015 | CIN | Iglesias,J | Activated from Injured List | | | Before |
| 5/14/2015 | GAR | Arencibia | Demoted to reserve roster | | | Before |
| 5/14/2015 | GAR | Gimenez | Promoted to active roster | | | Before |
| 5/14/2015 | GAR | Herrera,O | Activated from Injured List | | | Before |
| 5/14/2015 | GAR | Shuck | Demoted to reserve roster | | | Before |
| 5/14/2015 | SOI | Bauer | Demoted to reserve roster | | | Before |
| 5/14/2015 | SOI | Detwiler | Promoted to active roster | | | Before |
| 5/14/2015 | SOI | Gibson | Demoted to reserve roster | | | Before |
| 5/14/2015 | SOI | Lincecum | Promoted to active roster | | | Before |
| 5/15/2015 | CAR | Chavez | Placed on Injured List | | 5/15/2015 | Before |
| 5/15/2015 | CAR | McAllister | Promoted to active roster | | | Before |
| 5/15/2015 | CTW | Godley | Demoted to reserve roster | | | Before |
| 5/15/2015 | CTW | Leone | Promoted to active roster | | | Before |
| 5/15/2015 | NEP | Seager,C | Placed on Injured List | | 5/15/2015 | Before |
| 5/15/2015 | TEW | Garza | Activated from Injured List | | | Before |
| 5/15/2015 | TEW | Wainwright | Demoted to reserve roster | | | Before |
| 5/16/2015 | CEN | Bedrosian | Activated from Injured List | | | Before |
| 5/16/2015 | CEN | Neris | Demoted to reserve roster | | | Before |
| 5/16/2015 | CSS | Lamb,Ja | Promoted to active roster | | | Before |
| 5/16/2015 | CSS | Rosales | Demoted to reserve roster | | | Before |
| 5/16/2015 | HAR | Grandal | Activated from Injured List | | | Before |
| 5/16/2015 | HAR | Navarro,D | Demoted to reserve roster | | | Before |
| 5/16/2015 | HAR | Pearce | Demoted to reserve roster | | | Before |
| 5/16/2015 | HAR | Wright,D | Activated from Injured List | | | Before |
| 5/16/2015 | NEP | Ahmed | Promoted to active roster | | | Before |
| 5/16/2015 | NEP | Almonte,A | Promoted to active roster | | | Before |
| 5/16/2015 | NEP | den Dekker | Demoted to reserve roster | | | Before |
| 5/16/2015 | RMO | Beckham,G | Promoted to active roster | | | Before |
| 5/16/2015 | RMO | Vargas,J | Demoted to reserve roster | | | Before |
| 5/17/2015 | ANN | Alberto | Demoted to reserve roster | | | Before |
| 5/17/2015 | ANN | Goins | Promoted to active roster | | | Before |
| 5/17/2015 | CAR | Johnson,C | Demoted to reserve roster | | | Before |
| 5/17/2015 | CAR | Osich | Promoted to active roster | | | Before |
| 5/17/2015 | CTW | Barnhart | Promoted to active roster | | | Before |
| 5/17/2015 | CTW | Rojas | Demoted to reserve roster | | | Before |
| 5/17/2015 | GAR | Buehrle | Placed on Injured List | | 5/17/2015 | Before |
| 5/17/2015 | GAR | Volquez | Promoted to active roster | | | Before |
| 5/18/2015 | BRK | Buxton | Demoted to reserve roster | | | Before |
| 5/18/2015 | BRK | Hicks,A | Promoted to active roster | | | Before |
| 5/18/2015 | CEN | Travis | Promoted to active roster | | | Before |
| 5/18/2015 | CEN | Turner,T | Demoted to reserve roster | | | Before |
| 5/18/2015 | CSS | Bradley,J | Placed on Injured List | | 5/18/2015 | Before |
| 5/18/2015 | CSS | Gausman | Demoted to reserve roster | | | Before |
| 5/18/2015 | CSS | Myers | Promoted to active roster | | | Before |
| 5/18/2015 | CSS | Wood,A | Activated from Injured List | | | Before |
| 5/18/2015 | GAR | Duffey | Demoted to reserve roster | | | Before |
| 5/18/2015 | GAR | Pineda | Promoted to active roster | | | Before |
| 5/18/2015 | SOI | Bauer | Promoted to active roster | | | Before |
| 5/18/2015 | SOI | Corbin | Placed on Injured List | | 5/15/2015 | Before |
| 5/18/2015 | SOI | Detwiler | Demoted to reserve roster | | | Before |
| 5/18/2015 | SOI | Gibson | Promoted to active roster | | | Before |
| 5/19/2015 | BRK | Correa | Promoted to active roster | | | Before |
| 5/19/2015 | BRK | Infante | Demoted to reserve roster | | | Before |
| 5/20/2015 | BAR | Eickhoff | Demoted to reserve roster | | | Before |
| 5/20/2015 | BAR | Hill,R | Promoted to active roster | | | Before |
| 5/20/2015 | CAR | Johnson,C | Promoted to active roster | | | Before |
| 5/20/2015 | CAR | Osich | Demoted to reserve roster | | | Before |
| 5/20/2015 | FDH | Blair | Promoted to active roster | | | Before |
| 5/20/2015 | FDH | Tomlinson | Demoted to reserve roster | | | Before |
| 5/20/2015 | TEW | Chacin | Demoted to reserve roster | | | Before |
| 5/20/2015 | TEW | Foltynewicz | Activated from Injured List | | | Before |
| 5/21/2015 | BBG | Shields | Promoted to active roster | | | Before |
| 5/21/2015 | BBG | Smyly | Demoted to reserve roster | | | Before |
| 5/22/2015 | CTW | Martinez,N | Promoted to active roster | | | Before |
| 5/22/2015 | CTW | Severino,L | Demoted to reserve roster | | | Before |
| 5/22/2015 | HHR | Holliday | Activated from Injured List | | | Before |
| 5/22/2015 | HHR | Polanco,G | Demoted to reserve roster | | | Before |
| 5/23/2015 | HAR | Navarro,D | Promoted to active roster | | | Before |
| 5/23/2015 | HAR | Wright,D | Placed on Injured List | | 5/23/2015 | Before |
| 5/23/2015 | NEP | Conforto | Demoted to reserve roster | | | Before |
| 5/23/2015 | NEP | Ethier | Activated from Injured List | | | Before |
| 5/23/2015 | NEP | Givens | Demoted to reserve roster | | | Before |
| 5/23/2015 | NEP | Kelley | Promoted to active roster | | | Before |
| 5/23/2015 | NEP | Peavy | Promoted to active roster | | | Before |
| 5/23/2015 | NEP | Tanaka | Demoted to reserve roster | | | Before |
| 5/23/2015 | NYD | Cozart | Placed on Injured List | | 5/23/2015 | Before |
| 5/23/2015 | NYD | Ynoa | Promoted to active roster | | | Before |
| 5/24/2015 | CEN | Barney | Demoted to reserve roster | | | Before |
| 5/24/2015 | CEN | Sanchez,H | Promoted to active roster | | | Before |
| 5/24/2015 | CIO | Betances | Demoted to reserve roster | | | Before |
| 5/24/2015 | CIO | Sipp | Promoted to active roster | | | Before |
| 5/24/2015 | CSS | Beckham,T | Promoted to active roster | | | Before |
| 5/24/2015 | CSS | Braun | Placed on Injured List | | 5/23/2015 | Before |
| 5/24/2015 | CSS | Jones,N | Placed on Injured List | | 5/23/2015 | Before |
| 5/24/2015 | CSS | LeMahieu | Placed on Injured List | | 5/23/2015 | Before |
| 5/24/2015 | CSS | Ross,D | Promoted to active roster | | | Before |
| 5/24/2015 | CSS | Thornburg | Promoted to active roster | | | Before |
| 5/25/2015 | ANN | Gomes,Y | Placed on Injured List | | 5/25/2015 | Before |
| 5/25/2015 | ANN | Plawecki | Promoted to active roster | | | Before |
| 5/25/2015 | CEN | Barney | Promoted to active roster | | | Before |
| 5/25/2015 | CEN | Sanchez,H | Demoted to reserve roster | | | Before |
| 5/25/2015 | CTW | Gray,J | Demoted to reserve roster | | | Before |
| 5/25/2015 | CTW | Matzek | Promoted to active roster | | | Before |
| 5/25/2015 | NYD | Byrd | Demoted to reserve roster | | | Before |
| 5/25/2015 | NYD | Yelich | Activated from Injured List | | | Before |
| 5/26/2015 | FDH | Blair | Demoted to reserve roster | | | Before |
| 5/26/2015 | FDH | Gordon,A | Placed on Injured List | | 5/26/2015 | Before |
| 5/26/2015 | FDH | Tomlinson | Promoted to active roster | | | Before |
| 5/27/2015 | BRK | Lohse | Placed on Injured List | | 5/27/2015 | Before |
| 5/27/2015 | BRK | Paxton | Promoted to active roster | | | Before |
| 5/27/2015 | CEN | Duvall | Demoted to reserve roster | | | Before |
| 5/27/2015 | CEN | Marte,J | Promoted to active roster | | | Before |
| 5/27/2015 | CEN | May | Promoted to active roster | | | Before |
| 5/27/2015 | CEN | Norris,Da | Demoted to reserve roster | | | Before |
| 5/27/2015 | CIO | Buchholz | Promoted to active roster | | | Before |
| 5/27/2015 | CIO | Kazmir | Demoted to reserve roster | | | Before |
| 5/29/2015 | CIN | Allen | Demoted to reserve roster | | | Before |
| 5/29/2015 | CIN | Goeddel | Promoted to active roster | | | Before |
| 5/29/2015 | CIN | Hoover | Demoted to reserve roster | | | Before |
| 5/29/2015 | CIN | Miller,A | Promoted to active roster | | | Before |
| 5/29/2015 | CIN | Sanchez,An | Demoted to reserve roster | | | Before |
| 5/29/2015 | CIN | Stroman | Promoted to active roster | | | Before |
| 5/29/2015 | CIN | Wilhelmsen | Promoted to active roster | | | Before |
| 5/29/2015 | CIN | Wood,T | Demoted to reserve roster | | | Before |
| 5/29/2015 | FDH | Gomez,C | Promoted to active roster | | | Before |
| 5/30/2015 | CAR | Chavez | Activated from Injured List | | | Before |
| 5/30/2015 | CAR | McAllister | Demoted to reserve roster | | | Before |
| 5/30/2015 | GAR | Encarnacion | Placed on Injured List | | 5/30/2015 | Before |
| 5/30/2015 | GAR | Robinson,C | Promoted to active roster | | | Before |
| 5/30/2015 | HHR | Elias | Promoted to active roster | | | Before |
| 5/30/2015 | HHR | Kimbrel | Promoted to active roster | | | Before |
| 5/30/2015 | HHR | Shreve | Demoted to reserve roster | | | Before |
| 5/30/2015 | NEP | Lopez,Ja | Promoted to active roster | | | Before |
| 5/30/2015 | NEP | Wilson,A | Demoted to reserve roster | | | Before |
| 5/30/2015 | SOI | Corbin | Activated from Injured List | | | Before |
| 5/30/2015 | SOI | Nola | Demoted to reserve roster | | | Before |
| 5/30/2015 | TEW | Colome | Activated from Injured List | | | Before |
| 5/30/2015 | TEW | Vincent | Demoted to reserve roster | | | Before |
| 6/1/2015 | ANN | Leake | Activated from Injured List | | | Before |
| 6/1/2015 | ANN | Nuno | Demoted to reserve roster | | | Before |
| 6/1/2015 | CSS | Broxton,J | Promoted to active roster | | | Before |
| 6/1/2015 | CSS | Thornburg | Demoted to reserve roster | | | Before |
| 6/1/2015 | FDH | McCullers | Promoted to active roster | | | Before |
| 6/1/2015 | FDH | McHugh | Demoted to reserve roster | | | Before |
| 6/1/2015 | FDH | Qualls | Promoted to active roster | | | Before |
| 6/1/2015 | FDH | Schultz | Demoted to reserve roster | | | Before |
| 6/2/2015 | CAR | Hudson,D | Promoted to active roster | | | Before |
| 6/2/2015 | CAR | Venable | Demoted to reserve roster | | | Before |
| 6/2/2015 | CAR | Iglesias,R | Traded away | RMO | | After |
| 6/2/2015 | CAR | Reddick | Acquired via trade | RMO | | After |
| 6/2/2015 | CSS | Bradley,J | Activated from Injured List | | | Before |
| 6/2/2015 | CSS | Myers | Demoted to reserve roster | | | Before |
| 6/2/2015 | RMO | Aardsma | Demoted to reserve roster | | | Before |
| 6/2/2015 | RMO | Callaspo | Demoted to reserve roster | | | Before |
| 6/2/2015 | RMO | Callaspo | Promoted to active roster | | | Before |
| 6/2/2015 | RMO | Gallo | Demoted to reserve roster | | | Before |
| 6/2/2015 | RMO | Hill,A | Promoted to active roster | | | Before |
| 6/2/2015 | RMO | Sucre | Promoted to active roster | | | Before |
| 6/2/2015 | RMO | Villanueva | Demoted to reserve roster | | | Before |
| 6/2/2015 | RMO | Walker,C | Promoted to active roster | | | Before |
| 6/2/2015 | RMO | Iglesias,R | Acquired via trade | CAR | | After |
| 6/2/2015 | RMO | Reddick | Traded away | CAR | | After |
| 6/3/2015 | BRK | Baez,J | Demoted to reserve roster | | | Before |
| 6/3/2015 | BRK | Greene | Demoted to reserve roster | | | Before |
| 6/3/2015 | BRK | Hardy,J | Activated from Injured List | | | Before |
| 6/3/2015 | BRK | Hardy,J | Demoted to reserve roster | | | Before |
| 6/3/2015 | BRK | Hedges | Demoted to reserve roster | | | Before |
| 6/3/2015 | BRK | Iannetta | Promoted to active roster | | | Before |
| 6/3/2015 | BRK | Osuna | Promoted to active roster | | | Before |
| 6/3/2015 | BRK | Stanton | Promoted to active roster | | | Before |
| 6/4/2015 | BAR | Pena,B | Promoted to active roster | | | Before |
| 6/4/2015 | BAR | Wieters | Placed on Injured List | | 6/3/2015 | Before |
| 6/4/2015 | CSS | Gausman | Promoted to active roster | | | Before |
| 6/4/2015 | CSS | Happ | Demoted to reserve roster | | | Before |
| 6/4/2015 | CTW | Callaspo | Acquired via trade | RMO | | After |
| 6/4/2015 | CTW | Moss | Traded away | RMO | | After |
| 6/4/2015 | CTW | Nelson | Acquired via trade | RMO | | After |
| 6/4/2015 | CTW | Reynolds,Mar | Traded away | RMO | | After |
| 6/4/2015 | RMO | Callaspo | Traded away | CTW | | After |
| 6/4/2015 | RMO | Moss | Acquired via trade | CTW | | After |
| 6/4/2015 | RMO | Nelson | Traded away | CTW | | After |
| 6/4/2015 | RMO | Reynolds,Mar | Acquired via trade | CTW | | After |
| 6/4/2015 | SOI | McFarland | Demoted to reserve roster | | | Before |
| 6/4/2015 | SOI | Pressly | Promoted to active roster | | | Before |
| 6/5/2015 | BBG | Alburquerque | Promoted to active roster | | | Before |
| 6/5/2015 | BBG | Worley | Demoted to reserve roster | | | Before |
| 6/5/2015 | CEN | Adams,M | Promoted to active roster | | | Before |
| 6/5/2015 | CEN | Teixeira | Demoted to reserve roster | | | Before |
| 6/5/2015 | CTW | Matzek | Demoted to reserve roster | | | Before |
| 6/5/2015 | NEP | Barnes,A | Promoted to active roster | | | Before |
| 6/5/2015 | NEP | Conger | Demoted to reserve roster | | | Before |
| 6/5/2015 | NEP | Fields,J | Demoted to reserve roster | | | Before |
| 6/5/2015 | NEP | Wilson,A | Promoted to active roster | | | Before |
| 6/5/2015 | RMO | Abad | Promoted to active roster | | | Before |
| 6/5/2015 | RMO | de la Rosa,R | Demoted to reserve roster | | | Before |
| 6/5/2015 | RMO | Urena | Promoted to active roster | | | Before |
| 6/7/2015 | GAR | Buehrle | Activated from Injured List | | | Before |
| 6/7/2015 | GAR | Volquez | Demoted to reserve roster | | | Before |
| 6/8/2015 | HAR | Barraclough | Demoted to reserve roster | | | Before |
| 6/8/2015 | NYD | Heathcott | Demoted to reserve roster | | | Before |