| Transactions |
| Date | Team | Player | Type | OthTm | EffDate | When |
| 3/30/2010 | DLM | Hundley | Promoted to active roster | | | Before |
| 3/30/2010 | GAR | Ankiel | Placed on Injured List | | 3/30/2010 | Before |
| 3/30/2010 | GAR | Ludwick | Promoted to active roster | | | Before |
| 3/31/2010 | CIN | Ciriaco | Demoted to reserve roster | | | Before |
| 3/31/2010 | CIN | Ramirez,Al | Promoted to active roster | | | Before |
| 3/31/2010 | DLM | Lucroy | Placed on Injured List | | 3/30/2010 | Before |
| 3/31/2010 | TEW | Buchholz,T | Promoted to active roster | | | Before |
| 3/31/2010 | TEW | Moscoso | Demoted to reserve roster | | | Before |
| 4/1/2010 | CTW | Carmona | Demoted to reserve roster | | | Before |
| 4/1/2010 | CTW | Chacin,J | Promoted to active roster | | | Before |
| 4/3/2010 | CIN | Trumbo | Demoted to reserve roster | | | Before |
| 4/3/2010 | CIN | Willingham | Promoted to active roster | | | Before |
| 4/4/2010 | DLM | Podsednik | Promoted to active roster | | | Before |
| 4/4/2010 | DLM | Span | Placed on Injured List | | 4/1/2010 | Before |
| 4/7/2010 | DLM | DeWitt | Demoted to reserve roster | | | Before |
| 4/7/2010 | DLM | Redmond | Promoted to active roster | | | Before |
| 4/7/2010 | GAR | Barmes | Placed on Injured List | | 4/7/2010 | Before |
| 4/7/2010 | GAR | Grudzielanek | Promoted to active roster | | | Before |
| 4/8/2010 | CIN | Freeman | Demoted to reserve roster | | | Before |
| 4/8/2010 | CIN | Kottaras | Promoted to active roster | | | Before |
| 4/10/2010 | DLM | DeWitt | Promoted to active roster | | | Before |
| 4/10/2010 | DLM | Hundley | Demoted to reserve roster | | | Before |
| 4/10/2010 | GAR | Arrieta | Placed on Injured List | | 4/10/2010 | Before |
| 4/10/2010 | GAR | Wakefield | Promoted to active roster | | | Before |
| 4/11/2010 | CIN | Arencibia | Demoted to reserve roster | | | Before |
| 4/11/2010 | CIN | Jennings | Demoted to reserve roster | | | Before |
| 4/11/2010 | CIN | Pena,B | Promoted to active roster | | | Before |
| 4/11/2010 | CIN | Young,E | Promoted to active roster | | | Before |
| 4/13/2010 | GAR | Grudzielanek | Demoted to reserve roster | | | Before |
| 4/13/2010 | GAR | Wigginton | Promoted to active roster | | | Before |
| 4/14/2010 | DLM | Pestano | Demoted to reserve roster | | | Before |
| 4/15/2010 | BBG | Harrison | Promoted to active roster | | | Before |
| 4/15/2010 | BBG | Johnson,Jo | Placed on Injured List | | 4/15/2010 | Before |
| 4/15/2010 | GAR | Bradley | Promoted to active roster | | | Before |
| 4/15/2010 | GAR | Dyson | Demoted to reserve roster | | | Before |
| 4/16/2010 | AST | Wilson,Jo | Demoted to reserve roster | | | Before |
| 4/16/2010 | AST | Wilson,Jo | Promoted to active roster | | | Before |
| 4/16/2010 | TEW | Hudson,O | Placed on Injured List | | 4/16/2010 | Before |
| 4/16/2010 | TEW | Mora | Promoted to active roster | | | Before |
| 4/17/2010 | BBG | Hanigan | Placed on Injured List | | 4/17/2010 | Before |
| 4/17/2010 | BBG | Olivo | Promoted to active roster | | | Before |
| 4/17/2010 | CIN | Miller,C | Promoted to active roster | | | Before |
| 4/17/2010 | CIN | Saltalamacchia | Demoted to reserve roster | | | Before |
| 4/18/2010 | CTW | Kuo | Placed on Injured List | | 4/18/2010 | Before |
| 4/18/2010 | CTW | Lopez,W | Promoted to active roster | | | Before |
| 4/18/2010 | GAR | McKenry | Demoted to reserve roster | | | Before |
| 4/18/2010 | GAR | Snyder,C | Promoted to active roster | | | Before |
| 4/18/2010 | NEP | Jaso | Placed on Injured List | | 4/18/2010 | Before |
| 4/18/2010 | NEP | Kratz | Promoted to active roster | | | Before |
| 4/20/2010 | BBG | De Aza | Promoted to active roster | | | Before |
| 4/20/2010 | BBG | Mayberry | Demoted to reserve roster | | | Before |
| 4/20/2010 | CTW | Joyce | Promoted to active roster | | | Before |
| 4/20/2010 | CTW | Venable | Placed on Injured List | | 4/19/2010 | Before |
| 4/22/2010 | CIN | Frieri | Promoted to active roster | | | Before |
| 4/22/2010 | CIN | Miller,A | Demoted to reserve roster | | | Before |
| 4/23/2010 | AST | Hairston,S | Promoted to active roster | | | Before |
| 4/23/2010 | AST | Lowrie | Placed on Injured List | | 4/23/2010 | Before |
| 4/23/2010 | AST | Lugo | Promoted to active roster | | | Before |
| 4/23/2010 | AST | Soriano,A | Demoted to reserve roster | | | Before |
| 4/23/2010 | TEW | Doumit | Placed on Injured List | | 4/23/2010 | Before |
| 4/23/2010 | TEW | Thole | Promoted to active roster | | | Before |
| 4/25/2010 | AST | Bush | Promoted to active roster | | | Before |
| 4/25/2010 | AST | Wright,J | Demoted to reserve roster | | | Before |
| 4/27/2010 | DLM | Lucroy | Activated from Injured List | | | Before |
| 4/27/2010 | DLM | O'Flaherty | Placed on Injured List | | 4/27/2010 | Before |
| 4/27/2010 | DLM | Rapada | Promoted to active roster | | | Before |
| 4/27/2010 | DLM | Redmond | Demoted to reserve roster | | | Before |
| 4/27/2010 | NEP | Belisario | Placed on Injured List | | 4/27/2010 | Before |
| 4/27/2010 | NEP | Harrell | Promoted to active roster | | | Before |
| 5/1/2010 | DLM | Pineiro | Promoted to active roster | | | Before |
| 5/1/2010 | GAR | Gload | Promoted to active roster | | | Before |
| 5/1/2010 | GAR | Hoffman | Promoted to active roster | | | Before |
| 5/1/2010 | GAR | Manship | Demoted to reserve roster | | | Before |
| 5/1/2010 | GAR | Stairs | Demoted to reserve roster | | | Before |
| 5/3/2010 | AST | Donaldson | Demoted to reserve roster | | | Before |
| 5/3/2010 | AST | Sardinha | Promoted to active roster | | | Before |
| 5/3/2010 | CTW | Medlen | Promoted to active roster | | | Before |
| 5/3/2010 | CTW | Stauffer | Placed on Injured List | | 5/3/2010 | Before |
| 5/3/2010 | GAR | Barmes | Activated from Injured List | | | Before |
| 5/3/2010 | GAR | Gload | Placed on Injured List | | 5/3/2010 | Before |
| 5/3/2010 | GAR | Gomes | Promoted to active roster | | | Before |
| 5/3/2010 | GAR | Wigginton | Demoted to reserve roster | | | Before |
| 5/5/2010 | BAR | Mazzaro | Promoted to active roster | | | Before |
| 5/5/2010 | BAR | Minor | Demoted to reserve roster | | | Before |
| 5/5/2010 | CTW | Venable | Activated from Injured List | | | Before |
| 5/5/2010 | CTW | Young,Delm | Demoted to reserve roster | | | Before |
| 5/5/2010 | DLM | Podsednik | Placed on Injured List | | 5/4/2010 | Before |
| 5/5/2010 | DLM | Span | Activated from Injured List | | | Before |
| 5/5/2010 | NEP | Jaso | Activated from Injured List | | | Before |
| 5/5/2010 | NEP | Kratz | Demoted to reserve roster | | | Before |
| 5/8/2010 | TEW | Doumit | Activated from Injured List | | | Before |
| 5/8/2010 | TEW | Thole | Demoted to reserve roster | | | Before |
| 5/9/2010 | BAR | Abad | Demoted to reserve roster | | | Before |
| 5/9/2010 | BAR | Lindstrom | Promoted to active roster | | | Before |
| 5/9/2010 | BBG | Hanigan | Activated from Injured List | | | Before |
| 5/9/2010 | BBG | Harrison | Demoted to reserve roster | | | Before |
| 5/9/2010 | BBG | Jansen | Demoted to reserve roster | | | Before |
| 5/9/2010 | BBG | Oliver,D | Promoted to active roster | | | Before |
| 5/9/2010 | BBG | Olivo | Demoted to reserve roster | | | Before |
| 5/10/2010 | AST | Bush | Demoted to reserve roster | | | Before |
| 5/10/2010 | AST | Soriano,A | Promoted to active roster | | | Before |
| 5/10/2010 | BBG | Johnson,Jo | Activated from Injured List | | | Before |
| 5/10/2010 | GAR | Arrieta | Activated from Injured List | | | Before |
| 5/10/2010 | GAR | Moyer | Demoted to reserve roster | | | Before |
| 5/10/2010 | TEW | Hudson,O | Activated from Injured List | | | Before |
| 5/10/2010 | TEW | Mora | Demoted to reserve roster | | | Before |
| 5/11/2010 | CIN | Elbert | Promoted to active roster | | | Before |
| 5/11/2010 | CIN | Frieri | Demoted to reserve roster | | | Before |
| 5/11/2010 | CIN | LeCure | Demoted to reserve roster | | | Before |
| 5/11/2010 | CIN | Logan | Promoted to active roster | | | Before |
| 5/11/2010 | CIN | Perez,C | Promoted to active roster | | | Before |
| 5/11/2010 | CIN | Perez,O | Demoted to reserve roster | | | Before |
| 5/11/2010 | CIN | Simon | Demoted to reserve roster | | | Before |
| 5/11/2010 | CIN | Villanueva | Promoted to active roster | | | Before |
| 5/12/2010 | BBG | De Aza | Demoted to reserve roster | | | Before |
| 5/12/2010 | BBG | Downs,M | Promoted to active roster | | | Before |
| 5/12/2010 | DLM | Norberto | Demoted to reserve roster | | | Before |
| 5/12/2010 | GAR | Ankiel | Activated from Injured List | | | Before |
| 5/12/2010 | GAR | Ludwick | Demoted to reserve roster | | | Before |
| 5/13/2010 | DLM | Happ | Promoted to active roster | | | Before |
| 5/13/2010 | DLM | Miller,T | Promoted to active roster | | | Before |
| 5/13/2010 | DLM | Rapada | Demoted to reserve roster | | | Before |
| 5/13/2010 | NEP | Belisario | Activated from Injured List | | | Before |
| 5/13/2010 | NEP | Harrell | Demoted to reserve roster | | | Before |
| 5/14/2010 | CIN | Cordero,F | Promoted to active roster | | | Before |
| 5/14/2010 | CIN | Elbert | Demoted to reserve roster | | | Before |
| 5/14/2010 | CIN | Miller,A | Promoted to active roster | | | Before |
| 5/14/2010 | CIN | Perkins | Demoted to reserve roster | | | Before |
| 5/14/2010 | CTW | Kuo | Activated from Injured List | | | Before |
| 5/14/2010 | CTW | Medlen | Demoted to reserve roster | | | Before |
| 5/14/2010 | DLM | Lopez,R | Promoted to active roster | | | Before |
| 5/14/2010 | DLM | Pineiro | Placed on Injured List | | 5/14/2010 | Before |
| 5/15/2010 | CIN | Miller,C | Demoted to reserve roster | | | Before |
| 5/15/2010 | CIN | Valbuena | Promoted to active roster | | | Before |
| 5/17/2010 | GAR | Neshek | Promoted to active roster | | | Before |
| 5/17/2010 | GAR | Ross,T | Demoted to reserve roster | | | Before |
| 5/19/2010 | CEN | Furcal | Placed on Injured List | | 5/19/2010 | Before |
| 5/19/2010 | CEN | Izturis,M | Promoted to active roster | | | Before |
| 5/21/2010 | AST | Craig | Demoted to reserve roster | | | Before |
| 5/21/2010 | AST | Lowrie | Activated from Injured List | | | Before |
| 5/21/2010 | CEN | Carlin | Promoted to active roster | | | Before |
| 5/21/2010 | CEN | Molina,Y | Placed on Injured List | | 5/20/2010 | Before |
| 5/21/2010 | TEW | Cunningham | Demoted to reserve roster | | | Before |
| 5/21/2010 | TEW | Francisco,B | Promoted to active roster | | | Before |
| 5/22/2010 | BAR | Bourjos | Demoted to reserve roster | | | Before |
| 5/22/2010 | BAR | Francoeur | Placed on Injured List | | 5/22/2010 | Before |
| 5/22/2010 | BAR | Kelley | Promoted to active roster | | | Before |
| 5/22/2010 | BAR | Wise | Promoted to active roster | | | Before |
| 5/22/2010 | NEP | Jurrjens | Placed on Injured List | | 5/22/2010 | Before |
| 5/22/2010 | NEP | Matusz | Promoted to active roster | | | Before |
| 5/23/2010 | BBG | Harrison | Promoted to active roster | | | Before |
| 5/23/2010 | BBG | Lewis,C | Placed on Injured List | | 5/22/2010 | Before |
| 5/24/2010 | CIN | Cordero,F | Demoted to reserve roster | | | Before |
| 5/24/2010 | CIN | Frieri | Promoted to active roster | | | Before |
| 5/26/2010 | DLM | DeWitt | Demoted to reserve roster | | | Before |
| 5/26/2010 | DLM | Hundley | Promoted to active roster | | | Before |
| 5/27/2010 | NEP | McGehee | Demoted to reserve roster | | | Before |
| 5/27/2010 | NEP | Viciedo | Promoted to active roster | | | Before |
| 5/28/2010 | CEN | Deduno | Promoted to active roster | | | Before |
| 5/28/2010 | CEN | Floyd | Placed on Injured List | | 5/28/2010 | Before |
| 5/28/2010 | CIN | Perez,O | Promoted to active roster | | | Before |
| 5/28/2010 | CIN | Pettitte | Placed on Injured List | | 5/28/2010 | Before |
| 5/28/2010 | CTW | Hammel | Demoted to reserve roster | | | Before |
| 5/28/2010 | CTW | Stauffer | Activated from Injured List | | | Before |
| 5/29/2010 | CEN | Bard,J | Promoted to active roster | | | Before |
| 5/29/2010 | CEN | Carlin | Demoted to reserve roster | | | Before |
| 5/29/2010 | GAR | Gload | Activated from Injured List | | | Before |
| 5/29/2010 | GAR | Wallace | Placed on Injured List | | 5/29/2010 | Before |
| 5/29/2010 | TEW | Escobar,Y | Placed on Injured List | | 5/29/2010 | Before |
| 5/29/2010 | TEW | Guzman | Promoted to active roster | | | Before |
| 5/30/2010 | AST | Aybar,E | Demoted to reserve roster | | | Before |
| 5/30/2010 | AST | Belliard | Promoted to active roster | | | Before |
| 5/30/2010 | AST | Castillo,W | Placed on Injured List | | 5/29/2010 | Before |
| 5/30/2010 | AST | Lind | Placed on Injured List | | 5/27/2010 | Before |
| 5/30/2010 | AST | Punto | Promoted to active roster | | | Before |
| 5/30/2010 | AST | Wood,Br | Promoted to active roster | | | Before |
| 5/30/2010 | CEN | Deduno | Demoted to reserve roster | | | Before |
| 5/30/2010 | CEN | Dunn,M | Promoted to active roster | | | Before |
| 5/31/2010 | TEW | Buchholz,T | Demoted to reserve roster | | | Before |
| 5/31/2010 | TEW | Hernandez,Da | Promoted to active roster | | | Before |
| 6/1/2010 | AST | Bush | Promoted to active roster | | | Before |
| 6/1/2010 | AST | Davies | Demoted to reserve roster | | | Before |
| 6/1/2010 | AST | Norris | Placed on Injured List | | 6/1/2010 | Before |
| 6/1/2010 | AST | Richard | Promoted to active roster | | | Before |
| 6/5/2010 | AST | Sardinha | Demoted to reserve roster | | | Before |
| 6/5/2010 | AST | Teagarden | Promoted to active roster | | | Before |
| 6/5/2010 | CEN | Castro,R | Demoted to reserve roster | | | Before |
| 6/5/2010 | CEN | Molina,Y | Activated from Injured List | | | Before |
| 6/5/2010 | CTW | Hammel | Promoted to active roster | | | Before |
| 6/5/2010 | CTW | Medlen | Promoted to active roster | | | Before |
| 6/5/2010 | CTW | O'Day | Demoted to reserve roster | | | Before |
| 6/5/2010 | CTW | Stauffer | Demoted to reserve roster | | | Before |
| 6/5/2010 | GAR | Crain | Promoted to active roster | | | Before |
| 6/5/2010 | GAR | Park | Demoted to reserve roster | | | Before |
| 6/6/2010 | BBG | Harrison | Demoted to reserve roster | | | Before |
| 6/6/2010 | BBG | Lewis,C | Activated from Injured List | | | Before |
| 6/6/2010 | GAR | Madson | Demoted to reserve roster | | | Before |
| 6/6/2010 | GAR | McGee | Promoted to active roster | | | Before |
| 6/6/2010 | NEP | Hunter,Tom | Demoted to reserve roster | | | Before |
| 6/6/2010 | NEP | Jurrjens | Activated from Injured List | | | Before |
| 6/7/2010 | AST | Aybar,E | Promoted to active roster | | | Before |
| 6/7/2010 | AST | Lowrie | Demoted to reserve roster | | | Before |
| 6/9/2010 | AST | Davies | Promoted to active roster | | | Before |
| 6/9/2010 | AST | O'Sullivan | Promoted to active roster | | | Before |
| 6/9/2010 | AST | Ogando | Demoted to reserve roster | | | Before |
| 6/9/2010 | AST | Richard | Demoted to reserve roster | | | Before |
| 6/9/2010 | BAR | Francoeur | Activated from Injured List | | | Before |
| 6/9/2010 | BAR | Wise | Demoted to reserve roster | | | Before |
| 6/9/2010 | BBG | Aceves | Promoted to active roster | | | Before |
| 6/9/2010 | BBG | Peralta,Jo | Demoted to reserve roster | | | Before |
| 6/9/2010 | CIN | Cordero,F | Promoted to active roster | | | Before |
| 6/9/2010 | CIN | Miller,A | Demoted to reserve roster | | | Before |
| 6/10/2010 | GAR | Mahay | Promoted to active roster | | | Before |
| 6/10/2010 | GAR | Neshek | Demoted to reserve roster | | | Before |
| 6/11/2010 | AST | Belliard | Demoted to reserve roster | | | Before |
| 6/11/2010 | AST | Lind | Activated from Injured List | | | Before |
| 6/11/2010 | BAR | Schierholtz | Demoted to reserve roster | | | Before |
| 6/11/2010 | BAR | Wise | Promoted to active roster | | | Before |
| 6/12/2010 | BAR | Hester | Promoted to active roster | | | Before |
| 6/12/2010 | BAR | Wise | Demoted to reserve roster | | | Before |
| 6/14/2010 | BAR | Baker,S | Demoted to reserve roster | | | Before |
| 6/14/2010 | BAR | Baker,S | Acquired via trade | CSS | | After |
| 6/14/2010 | BAR | Myers | Traded away | CSS | | After |
| 6/14/2010 | NEP | Carter,VC | Promoted to active roster | | | Before |
| 6/14/2010 | NEP | Thames | Demoted to reserve roster | | | Before |
| 6/15/2010 | BAR | Baker,S | Promoted to active roster | | | Before |
| 6/15/2010 | BAR | Blanco,A | Demoted to reserve roster | | | Before |
| 6/15/2010 | BAR | Feldman | Demoted to reserve roster | | | Before |
| 6/15/2010 | BAR | Guillen,C | Promoted to active roster | | | Before |
| 6/15/2010 | BAR | Hester | Demoted to reserve roster | | | Before |
| 6/15/2010 | BAR | Moore,S | Demoted to reserve roster | | | Before |
| 6/15/2010 | BAR | Schierholtz | Promoted to active roster | | | Before |
| 6/15/2010 | BAR | Wise | Promoted to active roster | | | Before |
| 6/15/2010 | BBG | Betancourt,R | Demoted to reserve roster | | | Before |
| 6/15/2010 | BBG | Humber | Promoted to active roster | | | Before |
| 6/15/2010 | GAR | Blanton | Promoted to active roster | | | Before |
| 6/15/2010 | GAR | McGee | Demoted to reserve roster | | | Before |
| 6/16/2010 | GAR | Saunders,M | Demoted to reserve roster | | | Before |
| 6/16/2010 | GAR | Wallace | Activated from Injured List | | | Before |
| 6/16/2010 | TEW | Escobar,Y | Activated from Injured List | | | Before |
| 6/16/2010 | TEW | Francisco,B | Demoted to reserve roster | | | Before |
| 6/16/2010 | TEW | Guzman | Demoted to reserve roster | | | Before |
| 6/16/2010 | TEW | Mora | Promoted to active roster | | | Before |
| 6/16/2010 | TEW | Paulino,R | Demoted to reserve roster | | | Before |
| 6/16/2010 | TEW | Thole | Promoted to active roster | | | Before |
| 6/17/2010 | AST | Gomez,J | Demoted to reserve roster | | | Before |
| 6/17/2010 | AST | Norris | Activated from Injured List | | | Before |
| 6/18/2010 | CTW | Kimbrel | Promoted to active roster | | | Before |
| 6/18/2010 | CTW | Lopez,W | Demoted to reserve roster | | | Before |
| 6/18/2010 | CTW | O'Day | Promoted to active roster | | | Before |
| 6/18/2010 | CTW | Soriano,R | Demoted to reserve roster | | | Before |
| 6/18/2010 | GAR | Arrieta | Placed on Injured List | | 6/17/2010 | Before |
| 6/18/2010 | GAR | Volstad | Promoted to active roster | | | Before |
| 6/19/2010 | CIN | Cordero,F | Demoted to reserve roster | | | Before |
| 6/19/2010 | CIN | Perez,O | Demoted to reserve roster | | | Before |
| 6/19/2010 | CIN | Pettitte | Activated from Injured List | | | Before |
| 6/19/2010 | CIN | Simon | Promoted to active roster | | | Before |
| 6/22/2010 | BAR | Blevins | Demoted to reserve roster | | | Before |
| 6/22/2010 | BAR | Roenicke | Promoted to active roster | | | Before |
| 6/22/2010 | CTW | Barton | Promoted to active roster | | | Before |
| 6/22/2010 | CTW | Morales,K | Placed on Injured List | | 6/22/2010 | Before |
| 6/23/2010 | CTW | Medlen | Placed on Injured List | | 6/23/2010 | Before |
| 6/23/2010 | CTW | Stauffer | Promoted to active roster | | | Before |
| 6/29/2010 | BBG | Aceves | Demoted to reserve roster | | | Before |
| 6/29/2010 | BBG | Luebke | Promoted to active roster | | | Before |
| 6/29/2010 | CEN | Dunn,M | Demoted to reserve roster | | | Before |
| 6/29/2010 | CEN | Floyd | Activated from Injured List | | | Before |
| 6/29/2010 | CEN | Furcal | Activated from Injured List | | | Before |
| 6/29/2010 | CEN | Izturis,M | Demoted to reserve roster | | | Before |
| 6/30/2010 | GAR | Barmes | Placed on Injured List | | 6/30/2010 | Before |
| 6/30/2010 | GAR | Wigginton | Promoted to active roster | | | Before |
| 7/1/2010 | CIN | Butera | Promoted to active roster | | | Before |
| 7/1/2010 | CIN | Cairo | Demoted to reserve roster | | | Before |
| 7/1/2010 | TEW | Bard,D | Demoted to reserve roster | | | Before |
| 7/1/2010 | TEW | Callaspo | Demoted to reserve roster | | | Before |
| 7/1/2010 | TEW | Francisco,B | Promoted to active roster | | | Before |
| 7/1/2010 | TEW | Fukudome | Promoted to active roster | | | Before |
| 7/1/2010 | TEW | Hensley | Promoted to active roster | | | Before |
| 7/1/2010 | TEW | Jay | Demoted to reserve roster | | | Before |
| 7/2/2010 | BBG | Hanigan | Demoted to reserve roster | | | Before |
| 7/2/2010 | BBG | Olivo | Promoted to active roster | | | Before |
| 7/3/2010 | BAR | Qualls | Demoted to reserve roster | | | Before |
| 7/3/2010 | BAR | Valdes | Promoted to active roster | | | Before |
| 7/3/2010 | CIN | Frieri | Demoted to reserve roster | | | Before |
| 7/3/2010 | CIN | LeCure | Promoted to active roster | | | Before |
| 7/6/2010 | CEN | Casilla,A | Activated from Injured List | | | Before |
| 7/6/2010 | CEN | Casilla,A | Demoted to reserve roster | | | Before |
| 7/6/2010 | CEN | Dunn,M | Promoted to active roster | | | Before |
| 7/6/2010 | CEN | Maldonado | Promoted to active roster | | | Before |
| 7/6/2010 | CEN | Casilla,A | Acquired via trade | CIO | | After |
| 7/6/2010 | CEN | Dickey | Acquired via trade | CIO | | After |
| 7/6/2010 | CEN | Hammel | Acquired via trade | CTW | | After |
| 7/6/2010 | CEN | Hudson,T | Acquired via trade | CIO | | After |
| 7/6/2010 | CEN | Jimenez | Traded away | CTW | | After |
| 7/6/2010 | CEN | Marmol | Traded away | CTW | | After |
| 7/6/2010 | CEN | Medlen | Acquired via trade | CTW | | After |
| 7/6/2010 | CEN | Oswalt | Traded away | CIO | | After |
| 7/6/2010 | CEN | Santana,J | Traded away | CIO | | After |
| 7/6/2010 | CEN | Valencia | Traded away | CIO | | After |
| 7/6/2010 | CTW | Masset | Demoted to reserve roster | | | Before |
| 7/6/2010 | CTW | Hammel | Traded away | CEN | | After |
| 7/6/2010 | CTW | Jimenez | Acquired via trade | CEN | | After |
| 7/6/2010 | CTW | Marmol | Acquired via trade | CEN | | After |
| 7/6/2010 | CTW | Medlen | Traded away | CEN | | After |
| 7/7/2010 | CIN | Cordero,F | Promoted to active roster | | | Before |
| 7/7/2010 | CIN | Pena,B | Demoted to reserve roster | | | Before |
| 7/8/2010 | BAR | Kelley | Demoted to reserve roster | | | Before |
| 7/8/2010 | BAR | Veras | Promoted to active roster | | | Before |
| 7/8/2010 | CEN | Casilla,A | Promoted to active roster | | | Before |
| 7/8/2010 | CEN | Dunn,M | Demoted to reserve roster | | | Before |
| 7/8/2010 | CEN | Maldonado | Demoted to reserve roster | | | Before |
| 7/8/2010 | CEN | Medlen | Activated from Injured List | | | Before |
| 7/8/2010 | CTW | Lopez,W | Promoted to active roster | | | Before |
| 7/8/2010 | CTW | Stauffer | Placed on Injured List | | 7/8/2010 | Before |
| 7/8/2010 | NEP | Freese | Placed on Injured List | | 7/8/2010 | Before |
| 7/9/2010 | BAR | Choate | Promoted to active roster | | | Before |
| 7/9/2010 | BAR | Dotel | Demoted to reserve roster | | | Before |
| 7/9/2010 | NEP | Murphy,Do | Promoted to active roster | | | Before |
| 7/10/2010 | GAR | Ankiel | Demoted to reserve roster | | | Before |
| 7/10/2010 | GAR | Harris,W | Promoted to active roster | | | Before |
| 7/10/2010 | GAR | Kouzmanoff | Placed on Injured List | | 7/10/2010 | Before |
| 7/10/2010 | GAR | Ludwick | Promoted to active roster | | | Before |
| 7/11/2010 | CIN | Alvarez | Demoted to reserve roster | | | Before |
| 7/11/2010 | CIN | Cairo | Promoted to active roster | | | Before |
| 7/11/2010 | NEP | Cook | Promoted to active roster | | | Before |
| 7/11/2010 | NEP | Peavy | Demoted to reserve roster | | | Before |
| 7/12/2010 | AST | Crowe | Promoted to active roster | | | Before |
| 7/12/2010 | AST | Davies | Demoted to reserve roster | | | Before |
| 7/12/2010 | AST | Figueroa | Promoted to active roster | | | Before |
| 7/12/2010 | AST | McLouth | Demoted to reserve roster | | | Before |
| 7/12/2010 | AST | Crowe | Acquired via trade | CSS | | After |
| 7/12/2010 | AST | Figueroa | Acquired via trade | CSS | | After |
| 7/12/2010 | AST | Fuentes | Traded away | CSS | | After |
| 7/12/2010 | AST | Punto | Traded away | CSS | | After |
| 7/12/2010 | CEN | Bard,J | Placed on Injured List | | 7/12/2010 | Before |
| 7/12/2010 | CEN | Maldonado | Promoted to active roster | | | Before |
| 7/12/2010 | NEP | Francisco,F | Promoted to active roster | | | Before |
| 7/12/2010 | NEP | Wheeler | Demoted to reserve roster | | | Before |
| 7/13/2010 | GAR | Arrieta | Activated from Injured List | | | Before |
| 7/15/2010 | AST | Gonzalez,Alb | Promoted to active roster | | | Before |
| 7/15/2010 | AST | LaRoche,An | Promoted to active roster | | | Before |
| 7/15/2010 | AST | Lugo | Demoted to reserve roster | | | Before |
| 7/17/2010 | BAR | Pedroia | Placed on Injured List | | 7/17/2010 | Before |
| 7/17/2010 | BAR | Torres,C | Promoted to active roster | | | Before |
| 7/17/2010 | BBG | Hanigan | Promoted to active roster | | | Before |
| 7/17/2010 | BBG | Montero | Demoted to reserve roster | | | Before |
| 7/17/2010 | CEN | Dunn,M | Promoted to active roster | | | Before |
| 7/17/2010 | CEN | Guerrier | Demoted to reserve roster | | | Before |
| 7/17/2010 | CEN | Howard | Demoted to reserve roster | | | Before |
| 7/17/2010 | CEN | Izturis,M | Promoted to active roster | | | Before |
| 7/17/2010 | CEN | Jones,C | Demoted to reserve roster | | | Before |
| 7/17/2010 | CEN | Lowe,M | Promoted to active roster | | | Before |
| 7/17/2010 | CEN | Morrison | Demoted to reserve roster | | | Before |
| 7/17/2010 | CEN | Revere | Promoted to active roster | | | Before |
| 7/17/2010 | CEN | Roberts,R | Promoted to active roster | | | Before |
| 7/17/2010 | CEN | Santos | Demoted to reserve roster | | | Before |
| 7/17/2010 | CEN | Soria | Demoted to reserve roster | | | Before |
| 7/17/2010 | CEN | Wright,W | Promoted to active roster | | | Before |
| 7/17/2010 | TEW | Adams | Demoted to reserve roster | | | Before |
| 7/17/2010 | TEW | Johnson,Ji | Promoted to active roster | | | Before |
| 7/18/2010 | CEN | Dunn,M | Demoted to reserve roster | | | Before |
| 7/18/2010 | CEN | Infante,G | Promoted to active roster | | | Before |
| 7/18/2010 | DLM | Barney | Demoted to reserve roster | | | Before |
| 7/18/2010 | DLM | Frasor | Demoted to reserve roster | | | Before |
| 7/18/2010 | DLM | O'Flaherty | Activated from Injured List | | | Before |
| 7/18/2010 | DLM | Podsednik | Activated from Injured List | | | Before |
| 7/18/2010 | DLM | Smith,S | Demoted to reserve roster | | | Before |
| 7/18/2010 | DLM | Vizquel | Promoted to active roster | | | Before |
| 7/19/2010 | AST | Bush | Placed on Injured List | | 7/19/2010 | Before |
| 7/19/2010 | AST | Huff,D | Demoted to reserve roster | | | Before |
| 7/19/2010 | AST | McCutchen,D | Promoted to active roster | | | Before |
| 7/19/2010 | AST | Richard | Promoted to active roster | | | Before |
| 7/19/2010 | CIN | Garcia,F | Promoted to active roster | | | Before |
| 7/19/2010 | CIN | LeCure | Demoted to reserve roster | | | Before |
| 7/19/2010 | CTW | Albers | Promoted to active roster | | | Before |
| 7/19/2010 | CTW | Carmona | Promoted to active roster | | | Before |
| 7/19/2010 | CTW | Chacin,J | Demoted to reserve roster | | | Before |
| 7/19/2010 | CTW | Lopez,W | Demoted to reserve roster | | | Before |
| 7/19/2010 | CTW | O'Day | Demoted to reserve roster | | | Before |
| 7/19/2010 | CTW | Soriano,R | Promoted to active roster | | | Before |
| 7/20/2010 | BBG | Burnett,S | Promoted to active roster | | | Before |
| 7/20/2010 | BBG | Harrison | Promoted to active roster | | | Before |
| 7/20/2010 | BBG | Humber | Demoted to reserve roster | | | Before |
| 7/20/2010 | BBG | Marshall | Demoted to reserve roster | | | Before |
| 7/21/2010 | CIN | LaRue | Promoted to active roster | | | Before |
| 7/21/2010 | CIN | Willingham | Demoted to reserve roster | | | Before |
| 7/21/2010 | CTW | Cust | Promoted to active roster | | | Before |
| 7/21/2010 | CTW | Joyce | Demoted to reserve roster | | | Before |
| 7/21/2010 | GAR | Hoffman | Demoted to reserve roster | | | Before |
| 7/21/2010 | GAR | LeBlanc | Demoted to reserve roster | | | Before |
| 7/21/2010 | GAR | Willis | Promoted to active roster | | | Before |
| 7/22/2010 | BAR | Hawkins | Promoted to active roster | | | Before |
| 7/22/2010 | BAR | Storen | Demoted to reserve roster | | | Before |
| 7/22/2010 | CIN | Kendrick,K | Promoted to active roster | | | Before |
| 7/22/2010 | CIN | Simon | Demoted to reserve roster | | | Before |
| 7/22/2010 | NEP | Hunter,Tom | Promoted to active roster | | | Before |
| 7/22/2010 | NEP | Morrow | Demoted to reserve roster | | | Before |
| 7/23/2010 | CIN | Logan | Demoted to reserve roster | | | Before |
| 7/23/2010 | CIN | Perez,O | Promoted to active roster | | | Before |
| 7/26/2010 | BAR | Fien | Promoted to active roster | | | Before |
| 7/26/2010 | BAR | Roenicke | Demoted to reserve roster | | | Before |
| 7/26/2010 | BAR | Dunn,M | Acquired via trade | CEN | | After |
| 7/26/2010 | BAR | Ibanez | Acquired via trade | CEN | | After |
| 7/26/2010 | BAR | Qualls | Traded away | CEN | | After |
| 7/26/2010 | BAR | Silva | Traded away | CEN | | After |
| 7/26/2010 | CEN | Carlin | Promoted to active roster | | | Before |
| 7/26/2010 | CEN | Infante,G | Demoted to reserve roster | | | Before |
| 7/26/2010 | CEN | Dunn,M | Traded away | BAR | | After |
| 7/26/2010 | CEN | Ibanez | Traded away | BAR | | After |
| 7/26/2010 | CEN | Qualls | Acquired via trade | BAR | | After |
| 7/26/2010 | CEN | Silva | Acquired via trade | BAR | | After |
| 7/26/2010 | CIN | Bernadina | Promoted to active roster | | | Before |
| 7/26/2010 | CIN | Kottaras | Demoted to reserve roster | | | Before |
| 7/27/2010 | BAR | Hawkins | Demoted to reserve roster | | | Before |
| 7/27/2010 | BAR | Hester | Promoted to active roster | | | Before |
| 7/27/2010 | CEN | Bard,J | Activated from Injured List | | | Before |
| 7/27/2010 | CEN | Bray | Promoted to active roster | | | Before |
| 7/27/2010 | CEN | Carlin | Demoted to reserve roster | | | Before |
| 7/27/2010 | CEN | Lowe,M | Demoted to reserve roster | | | Before |
| 7/27/2010 | CEN | Silva | Promoted to active roster | | | Before |
| 7/27/2010 | CEN | Wright,W | Demoted to reserve roster | | | Before |
| 7/28/2010 | BAR | Shoppach | Placed on Injured List | | 7/28/2010 | Before |
| 7/29/2010 | AST | Davies | Promoted to active roster | | | Before |
| 7/29/2010 | AST | Fister | Demoted to reserve roster | | | Before |
| 7/29/2010 | AST | Wright,J | Traded away | CEN | | After |
| 7/29/2010 | AST | Wright,W | Acquired via trade | CEN | | After |
| 7/29/2010 | CEN | Maldonado | Demoted to reserve roster | | | Before |
| 7/29/2010 | CEN | Wright,J | Promoted to active roster | | | Before |
| 7/29/2010 | CEN | Duensing | Acquired via trade | DLM | | After |
| 7/29/2010 | CEN | Lowe,M | Traded away | DLM | | After |
| 7/29/2010 | CEN | Qualls | Traded away | DLM | | After |
| 7/29/2010 | CEN | Wright,J | Acquired via trade | AST | | After |
| 7/29/2010 | CEN | Wright,W | Traded away | AST | | After |
| 7/29/2010 | CTW | Kuo | Demoted to reserve roster | | | Before |
| 7/29/2010 | CTW | Lopez,W | Promoted to active roster | | | Before |
| 7/29/2010 | CTW | Soriano,R | Demoted to reserve roster | | | Before |
| 7/29/2010 | CTW | Stauffer | Activated from Injured List | | | Before |
| 7/29/2010 | CTW | Barton | Traded away | CIO | | After |
| 7/29/2010 | CTW | Buck,J | Acquired via trade | CIO | | After |
| 7/29/2010 | CTW | Morneau | Acquired via trade | CIO | | After |
| 7/29/2010 | DLM | Duensing | Traded away | CEN | | After |
| 7/29/2010 | DLM | Lowe,M | Acquired via trade | CEN | | After |
| 7/29/2010 | DLM | Qualls | Acquired via trade | CEN | | After |
| 7/29/2010 | TEW | Bard,D | Traded away | CIO | | After |
| 7/29/2010 | TEW | Belisle | Acquired via trade | CIO | | After |
| 7/29/2010 | TEW | Germano | Traded away | CIO | | After |
| 7/29/2010 | TEW | Rodriguez,A | Acquired via trade | CIO | | After |
| 7/31/2010 | BAR | Ibanez | Promoted to active roster | | | Before |
| 7/31/2010 | BBG | Cameron | Traded away | GAR | | After |
| 7/31/2010 | BBG | Gload | Acquired via trade | GAR | | After |
| 7/31/2010 | CEN | Bray | Demoted to reserve roster | | | Before |
| 7/31/2010 | CEN | Duensing | Promoted to active roster | | | Before |
| 7/31/2010 | CTW | Buck,J | Promoted to active roster | | | Before |
| 7/31/2010 | CTW | Santana,C | Demoted to reserve roster | | | Before |
| 7/31/2010 | GAR | Barmes | Activated from Injured List | | | Before |
| 7/31/2010 | GAR | Castro,S | Placed on Injured List | | 7/26/2010 | Before |
| 7/31/2010 | GAR | Cameron | Acquired via trade | BBG | | After |
| 7/31/2010 | GAR | Gload | Traded away | BBG | | After |
| 7/31/2010 | TEW | Belisle | Demoted to reserve roster | | | Before |
| 7/31/2010 | TEW | Mora | Demoted to reserve roster | | | Before |
| 7/31/2010 | TEW | Rodriguez,A | Promoted to active roster | | | Before |
| 8/1/2010 | AST | Wright,W | Promoted to active roster | | | Before |
| 8/1/2010 | AST | Ziegler | Demoted to reserve roster | | | Before |
| 8/1/2010 | BBG | Gload | Demoted to reserve roster | | | Before |
| 8/1/2010 | CIN | Miller,A | Promoted to active roster | | | Before |
| 8/1/2010 | CIN | Perez,O | Demoted to reserve roster | | | Before |
| 8/1/2010 | GAR | Cameron | Promoted to active roster | | | Before |
| 8/2/2010 | NEP | Belisario | Demoted to reserve roster | | | Before |
| 8/2/2010 | NEP | Carter,VC | Demoted to reserve roster | | | Before |
| 8/2/2010 | NEP | Freese | Activated from Injured List | | | Before |
| 8/2/2010 | NEP | Thayer | Promoted to active roster | | | Before |
| 8/3/2010 | AST | Bush | Activated from Injured List | | | Before |
| 8/3/2010 | AST | Richard | Demoted to reserve roster | | | Before |
| 8/3/2010 | BAR | Fien | Demoted to reserve roster | | | Before |
| 8/3/2010 | BAR | Morales,F | Promoted to active roster | | | Before |
| 8/3/2010 | BBG | Betemit | Demoted to reserve roster | | | Before |
| 8/3/2010 | BBG | Thome | Promoted to active roster | | | Before |
| 8/4/2010 | CEN | Guerrier | Promoted to active roster | | | Before |
| 8/4/2010 | CEN | Renteria | Demoted to reserve roster | | | Before |
| 8/4/2010 | CTW | Hall | Demoted to reserve roster | | | Before |
| 8/4/2010 | CTW | Morales,K | Activated from Injured List | | | Before |
| 8/5/2010 | GAR | Cruz,J | Promoted to active roster | | | Before |
| 8/5/2010 | GAR | Kouzmanoff | Activated from Injured List | | | Before |
| 8/5/2010 | GAR | Pena,T | Promoted to active roster | | | Before |
| 8/5/2010 | GAR | Rodney | Demoted to reserve roster | | | Before |
| 8/5/2010 | GAR | Wakefield | Demoted to reserve roster | | | Before |
| 8/5/2010 | NEP | Murphy,Do | Demoted to reserve roster | | | Before |
| 8/5/2010 | NEP | Ransom | Promoted to active roster | | | Before |
| 8/6/2010 | BAR | Feldman | Promoted to active roster | | | Before |
| 8/6/2010 | BAR | Hughes,P | Demoted to reserve roster | | | Before |
| 8/6/2010 | BAR | Mazzaro | Demoted to reserve roster | | | Before |
| 8/6/2010 | BAR | Volquez | Promoted to active roster | | | Before |
| 8/6/2010 | BBG | Betemit | Promoted to active roster | | | Before |
| 8/6/2010 | BBG | Downs,M | Demoted to reserve roster | | | Before |
| 8/6/2010 | BBG | Montero | Promoted to active roster | | | Before |
| 8/6/2010 | NEP | Byrdak | Demoted to reserve roster | | | Before |
| 8/6/2010 | NEP | Gregg | Promoted to active roster | | | Before |
| 8/7/2010 | BBG | Betemit | Demoted to reserve roster | | | Before |
| 8/7/2010 | NEP | Harrell | Promoted to active roster | | | Before |
| 8/7/2010 | NEP | Thayer | Demoted to reserve roster | | | Before |
| 8/7/2010 | TEW | Callaspo | Promoted to active roster | | | Before |
| 8/7/2010 | TEW | Rodriguez,A | Placed on Injured List | | 8/6/2010 | Before |
| 8/8/2010 | CIN | Fowler | Demoted to reserve roster | | | Before |
| 8/8/2010 | CIN | Molina,B | Promoted to active roster | | | Before |
| 8/8/2010 | GAR | Turner | Demoted to reserve roster | | | Before |
| 8/9/2010 | AST | Kuroda | Demoted to reserve roster | | | Before |
| 8/9/2010 | AST | Sonnanstine | Promoted to active roster | | | Before |
| 8/9/2010 | BAR | Pedroia | Activated from Injured List | | | Before |
| 8/9/2010 | CTW | Carmona | Demoted to reserve roster | | | Before |
| 8/9/2010 | CTW | Cust | Demoted to reserve roster | | | Before |
| 8/9/2010 | CTW | Kuo | Promoted to active roster | | | Before |
| 8/9/2010 | CTW | Soriano,R | Promoted to active roster | | | Before |
| 8/10/2010 | CIN | Bloomquist | Promoted to active roster | | | Before |
| 8/10/2010 | CIN | Frandsen | Demoted to reserve roster | | | Before |
| 8/11/2010 | BAR | Correia | Promoted to active roster | | | Before |
| 8/11/2010 | BAR | Hawkins | Promoted to active roster | | | Before |
| 8/11/2010 | BAR | Reyes,Jo | Demoted to reserve roster | | | Before |
| 8/11/2010 | BAR | Romero,R | Demoted to reserve roster | | | Before |
| 8/11/2010 | BAR | Torres,C | Demoted to reserve roster | | | Before |
| 8/11/2010 | BAR | Torres,C | Promoted to active roster | | | Before |
| 8/11/2010 | BAR | Torres,C | Demoted to reserve roster | | | Before |
| 8/11/2010 | NEP | Detwiler | Promoted to active roster | | | Before |
| 8/11/2010 | NEP | Jurrjens | Demoted to reserve roster | | | Before |
| 8/12/2010 | BBG | Betemit | Promoted to active roster | | | Before |
| 8/12/2010 | BBG | Luebke | Demoted to reserve roster | | | Before |
| 8/12/2010 | BBG | Montero | Demoted to reserve roster | | | Before |
| 8/12/2010 | BBG | Olivo | Activated from Injured List | | | Before |
| 8/12/2010 | BBG | Peralta,Jo | Promoted to active roster | | | Before |
| 8/12/2010 | CIN | Blum | Promoted to active roster | | | Before |
| 8/12/2010 | CIN | Cairo | Demoted to reserve roster | | | Before |
| 8/12/2010 | GAR | Grudzielanek | Promoted to active roster | | | Before |
| 8/12/2010 | GAR | Kouzmanoff | Placed on Injured List | | 8/12/2010 | Before |
| 8/12/2010 | NEP | McGehee | Promoted to active roster | | | Before |
| 8/12/2010 | NEP | Viciedo | Demoted to reserve roster | | | Before |
| 8/12/2010 | TEW | Martinez,C | Promoted to active roster | | | Before |
| 8/12/2010 | TEW | Meek | Demoted to reserve roster | | | Before |
| 8/13/2010 | CIN | Crisp | Demoted to reserve roster | | | Before |
| 8/13/2010 | CIN | Hairston,J | Promoted to active roster | | | Before |
| 8/13/2010 | TEW | Adams | Promoted to active roster | | | Before |
| 8/13/2010 | TEW | Janssen | Demoted to reserve roster | | | Before |
| 8/14/2010 | TEW | Estrada | Promoted to active roster | | | Before |
| 8/14/2010 | TEW | Latos | Placed on Injured List | | 8/14/2010 | Before |
| 8/16/2010 | GAR | Cruz,J | Demoted to reserve roster | | | Before |
| 8/17/2010 | GAR | Arrieta | Demoted to reserve roster | | | Before |
| 8/17/2010 | GAR | LeBlanc | Promoted to active roster | | | Before |
| 8/17/2010 | GAR | Mahay | Demoted to reserve roster | | | Before |
| 8/17/2010 | GAR | Moyer | Promoted to active roster | | | Before |
| 8/17/2010 | GAR | Park | Promoted to active roster | | | Before |
| 8/17/2010 | GAR | Sheets | Demoted to reserve roster | | | Before |
| 8/17/2010 | GAR | Suppan | Promoted to active roster | | | Before |
| 8/17/2010 | NEP | Harrell | Demoted to reserve roster | | | Before |
| 8/17/2010 | NEP | Wuertz | Promoted to active roster | | | Before |
| 8/18/2010 | BBG | Betancourt,R | Promoted to active roster | | | Before |
| 8/18/2010 | BBG | Kennedy,I | Demoted to reserve roster | | | Before |
| 8/18/2010 | CIN | Saltalamacchia | Promoted to active roster | | | Before |
| 8/18/2010 | CIN | Young,E | Placed on Injured List | | 8/18/2010 | Before |
| 8/18/2010 | NEP | Kratz | Promoted to active roster | | | Before |
| 8/18/2010 | NEP | Ransom | Demoted to reserve roster | | | Before |
| 8/19/2010 | NEP | Russell,J | Demoted to reserve roster | | | Before |
| 8/19/2010 | NEP | Rzepczynski | Promoted to active roster | | | Before |
| 8/20/2010 | AST | Descalso | Promoted to active roster | | | Before |
| 8/20/2010 | AST | Salazar | Demoted to reserve roster | | | Before |
| 8/20/2010 | CIN | Alvarez | Promoted to active roster | | | Before |
| 8/20/2010 | CIN | Hairston,J | Placed on Injured List | | 8/20/2010 | Before |
| 8/22/2010 | CTW | Chacin,J | Promoted to active roster | | | Before |
| 8/22/2010 | CTW | Kimbrel | Demoted to reserve roster | | | Before |
| 8/22/2010 | CTW | Santana,C | Promoted to active roster | | | Before |
| 8/22/2010 | CTW | Soriano,R | Demoted to reserve roster | | | Before |
| 8/22/2010 | TEW | Callaspo | Demoted to reserve roster | | | Before |
| 8/22/2010 | TEW | Rodriguez,A | Activated from Injured List | | | Before |
| 8/23/2010 | AST | Davies | Demoted to reserve roster | | | Before |
| 8/23/2010 | AST | Gaudin | Demoted to reserve roster | | | Before |
| 8/23/2010 | AST | Huff,D | Promoted to active roster | | | Before |
| 8/23/2010 | AST | Manuel | Promoted to active roster | | | Before |
| 8/23/2010 | CTW | Cust | Promoted to active roster | | | Before |
| 8/23/2010 | CTW | Santana,C | Demoted to reserve roster | | | Before |
| 8/24/2010 | CTW | Kimbrel | Promoted to active roster | | | Before |
| 8/24/2010 | CTW | Stauffer | Demoted to reserve roster | | | Before |
| 8/24/2010 | NEP | Belisario | Promoted to active roster | | | Before |
| 8/24/2010 | NEP | Rauch | Demoted to reserve roster | | | Before |
| 8/25/2010 | NEP | Belisario | Demoted to reserve roster | | | Before |
| 8/25/2010 | NEP | Harrell | Promoted to active roster | | | Before |
| 8/25/2010 | TEW | Inge | Demoted to reserve roster | | | Before |
| 8/25/2010 | TEW | Jay | Promoted to active roster | | | Before |
| 8/27/2010 | BAR | Lindstrom | Demoted to reserve roster | | | Before |
| 8/27/2010 | BAR | Walden | Promoted to active roster | | | Before |
| 8/27/2010 | BBG | Marshall | Promoted to active roster | | | Before |
| 8/27/2010 | BBG | Rivera,Ma | Demoted to reserve roster | | | Before |
| 8/27/2010 | CEN | Dickey | Placed on Injured List | | 8/24/2010 | Before |
| 8/27/2010 | CEN | Santos | Promoted to active roster | | | Before |
| 8/28/2010 | BAR | Correia | Placed on Injured List | | 8/28/2010 | Before |
| 8/28/2010 | BAR | Ramos,C | Promoted to active roster | | | Before |
| 8/28/2010 | BBG | Anderson,Bre | Promoted to active roster | | | Before |
| 8/28/2010 | BBG | Peralta,Jo | Demoted to reserve roster | | | Before |
| 8/28/2010 | CIN | Frieri | Promoted to active roster | | | Before |
| 8/28/2010 | CIN | Perez,C | Demoted to reserve roster | | | Before |
| 8/29/2010 | CIN | Perkins | Promoted to active roster | | | Before |
| 8/29/2010 | CIN | Villanueva | Demoted to reserve roster | | | Before |
| 8/29/2010 | CTW | Lopez,W | Demoted to reserve roster | | | Before |
| 8/29/2010 | GAR | Duda | Demoted to reserve roster | | | Before |
| 8/30/2010 | NEP | Kubel | Placed on Injured List | | 8/30/2010 | Before |
| 8/30/2010 | NEP | Thames | Promoted to active roster | | | Before |
| 8/31/2010 | DLM | Bumgarner | Placed on Injured List | | 8/28/2010 | Before |
| 8/31/2010 | DLM | Pineiro | Activated from Injured List | | | Before |
| 9/1/2010 | AST | Belliard | Promoted to active roster | | | Before |
| 9/1/2010 | AST | Castillo,W | Activated from Injured List | | | Before |
| 9/1/2010 | AST | Craig | Promoted to active roster | | | Before |
| 9/1/2010 | AST | Davies | Promoted to active roster | | | Before |
| 9/1/2010 | AST | Donaldson | Promoted to active roster | | | Before |
| 9/1/2010 | AST | Fister | Promoted to active roster | | | Before |
| 9/1/2010 | AST | Gaudin | Promoted to active roster | | | Before |
| 9/1/2010 | AST | Gomez,J | Promoted to active roster | | | Before |
| 9/1/2010 | AST | Kuroda | Promoted to active roster | | | Before |
| 9/1/2010 | AST | Lugo | Promoted to active roster | | | Before |
| 9/1/2010 | AST | Nickeas | Promoted to active roster | | | Before |
| 9/1/2010 | AST | Richard | Promoted to active roster | | | Before |
| 9/1/2010 | AST | Salazar | Promoted to active roster | | | Before |
| 9/1/2010 | AST | Sardinha | Promoted to active roster | | | Before |
| 9/1/2010 | AST | Ziegler | Promoted to active roster | | | Before |
| 9/1/2010 | BBG | Aceves | Promoted to active roster | | | Before |
| 9/1/2010 | BBG | De Aza | Promoted to active roster | | | Before |
| 9/1/2010 | BBG | Downs,M | Promoted to active roster | | | Before |
| 9/1/2010 | BBG | Gload | Promoted to active roster | | | Before |
| 9/1/2010 | BBG | Humber | Promoted to active roster | | | Before |
| 9/1/2010 | BBG | Jansen | Promoted to active roster | | | Before |
| 9/1/2010 | BBG | Kennedy,I | Promoted to active roster | | | Before |
| 9/1/2010 | BBG | Mayberry | Promoted to active roster | | | Before |
| 9/1/2010 | BBG | Montero | Promoted to active roster | | | Before |
| 9/1/2010 | BBG | Valdez,W | Promoted to active roster | | | Before |
| 9/1/2010 | BBG | Zito | Promoted to active roster | | | Before |
| 9/1/2010 | CEN | Bray | Promoted to active roster | | | Before |
| 9/1/2010 | CEN | Castro,R | Promoted to active roster | | | Before |
| 9/1/2010 | CEN | Fuld | Promoted to active roster | | | Before |
| 9/1/2010 | CEN | Howard | Promoted to active roster | | | Before |
| 9/1/2010 | CEN | Maldonado | Promoted to active roster | | | Before |
| 9/1/2010 | CEN | Morrison | Promoted to active roster | | | Before |
| 9/1/2010 | CEN | Soria | Promoted to active roster | | | Before |
| 9/1/2010 | CIN | Arencibia | Promoted to active roster | | | Before |
| 9/1/2010 | CIN | Elbert | Promoted to active roster | | | Before |
| 9/1/2010 | CIN | Frandsen | Promoted to active roster | | | Before |
| 9/1/2010 | CIN | Jennings | Promoted to active roster | | | Before |
| 9/1/2010 | CIN | Kottaras | Promoted to active roster | | | Before |
| 9/1/2010 | CIN | LeCure | Promoted to active roster | | | Before |
| 9/1/2010 | CIN | Logan | Promoted to active roster | | | Before |
| 9/1/2010 | CIN | Miller,C | Promoted to active roster | | | Before |
| 9/1/2010 | CIN | Pena,B | Promoted to active roster | | | Before |
| 9/1/2010 | CIN | Simon | Promoted to active roster | | | Before |
| 9/1/2010 | CIN | Trumbo | Promoted to active roster | | | Before |
| 9/1/2010 | CIN | Willingham | Promoted to active roster | | | Before |
| 9/1/2010 | CTW | Badenhop | Promoted to active roster | | | Before |
| 9/1/2010 | CTW | Barajas | Promoted to active roster | | | Before |
| 9/1/2010 | CTW | Carmona | Promoted to active roster | | | Before |
| 9/1/2010 | CTW | Colvin | Promoted to active roster | | | Before |
| 9/1/2010 | CTW | Everett | Promoted to active roster | | | Before |
| 9/1/2010 | CTW | Fox,J | Promoted to active roster | | | Before |
| 9/1/2010 | CTW | Hernandez,R | Promoted to active roster | | | Before |
| 9/1/2010 | CTW | Johnson,C | Promoted to active roster | | | Before |
| 9/1/2010 | CTW | Joyce | Promoted to active roster | | | Before |
| 9/1/2010 | CTW | Masset | Promoted to active roster | | | Before |
| 9/1/2010 | CTW | Moss | Promoted to active roster | | | Before |
| 9/1/2010 | CTW | O'Day | Promoted to active roster | | | Before |
| 9/1/2010 | CTW | Soriano,R | Promoted to active roster | | | Before |
| 9/1/2010 | CTW | Young,Delm | Promoted to active roster | | | Before |
| 9/1/2010 | DLM | Alonso | Promoted to active roster | | | Before |
| 9/1/2010 | DLM | Anderson,Bry | Promoted to active roster | | | Before |
| 9/1/2010 | DLM | DeWitt | Promoted to active roster | | | Before |
| 9/1/2010 | DLM | Frasor | Promoted to active roster | | | Before |
| 9/1/2010 | DLM | Lannan | Promoted to active roster | | | Before |
| 9/1/2010 | DLM | Lee,D | Promoted to active roster | | | Before |
| 9/1/2010 | DLM | Lewis,F | Promoted to active roster | | | Before |
| 9/1/2010 | DLM | Lowe,M | Promoted to active roster | | | Before |
| 9/1/2010 | DLM | Lucroy | Demoted to reserve roster | | | Before |
| 9/1/2010 | DLM | Mijares | Promoted to active roster | | | Before |
| 9/1/2010 | DLM | Miller,T | Demoted to reserve roster | | | Before |
| 9/1/2010 | DLM | Qualls | Promoted to active roster | | | Before |
| 9/1/2010 | DLM | Redmond | Promoted to active roster | | | Before |
| 9/1/2010 | DLM | Rivera,J | Promoted to active roster | | | Before |
| 9/1/2010 | DLM | Smith,S | Promoted to active roster | | | Before |
| 9/1/2010 | DLM | Wilson,Bo | Promoted to active roster | | | Before |
| 9/1/2010 | TEW | Belisle | Promoted to active roster | | | Before |
| 9/1/2010 | TEW | Borbon | Promoted to active roster | | | Before |
| 9/1/2010 | TEW | Callaspo | Promoted to active roster | | | Before |
| 9/1/2010 | TEW | Estrada | Demoted to reserve roster | | | Before |
| 9/1/2010 | TEW | Guzman | Promoted to active roster | | | Before |
| 9/1/2010 | TEW | Inge | Promoted to active roster | | | Before |
| 9/1/2010 | TEW | Jaramillo | Promoted to active roster | | | Before |
| 9/1/2010 | TEW | Meek | Promoted to active roster | | | Before |
| 9/1/2010 | TEW | Mora | Promoted to active roster | | | Before |
| 9/1/2010 | TEW | Ondrusek | Promoted to active roster | | | Before |
| 9/1/2010 | TEW | Overbay | Promoted to active roster | | | Before |
| 9/1/2010 | TEW | Patton | Promoted to active roster | | | Before |
| 9/1/2010 | TEW | Paulino,R | Promoted to active roster | | | Before |
| 9/1/2010 | TEW | Sanabia | Promoted to active roster | | | Before |
| 9/1/2010 | TEW | Schumaker | Promoted to active roster | | | Before |
| 9/2/2010 | AST | Donaldson | Demoted to reserve roster | | | Before |
| 9/2/2010 | CTW | Kuo | Demoted to reserve roster | | | Before |
| 9/2/2010 | CTW | Posey | Demoted to reserve roster | | | Before |
| 9/2/2010 | GAR | Ankiel | Promoted to active roster | | | Before |
| 9/2/2010 | GAR | Arrieta | Promoted to active roster | | | Before |
| 9/2/2010 | GAR | Ausmus | Promoted to active roster | | | Before |
| 9/2/2010 | GAR | Castro,S | Activated from Injured List | | | Before |
| 9/2/2010 | GAR | Dyson | Promoted to active roster | | | Before |
| 9/2/2010 | GAR | Hoffman | Promoted to active roster | | | Before |
| 9/2/2010 | GAR | Kouzmanoff | Activated from Injured List | | | Before |
| 9/2/2010 | GAR | Madson | Promoted to active roster | | | Before |
| 9/2/2010 | GAR | Mahay | Promoted to active roster | | | Before |
| 9/2/2010 | GAR | Manship | Promoted to active roster | | | Before |
| 9/2/2010 | GAR | Saunders,M | Promoted to active roster | | | Before |
| 9/2/2010 | GAR | Stairs | Promoted to active roster | | | Before |
| 9/2/2010 | GAR | Turner | Promoted to active roster | | | Before |
| 9/2/2010 | GAR | Wakefield | Promoted to active roster | | | Before |
| 9/2/2010 | GAR | Winn | Promoted to active roster | | | Before |
| 9/3/2010 | BAR | Hester | Demoted to reserve roster | | | Before |
| 9/3/2010 | BAR | Shoppach | Activated from Injured List | | | Before |
| 9/3/2010 | CIN | Cairo | Promoted to active roster | | | Before |
| 9/4/2010 | AST | McLouth | Promoted to active roster | | | Before |
| 9/4/2010 | BBG | Aceves | Demoted to reserve roster | | | Before |
| 9/4/2010 | CEN | Jones,C | Promoted to active roster | | | Before |
| 9/4/2010 | CIN | Hairston,J | Activated from Injured List | | | Before |
| 9/4/2010 | GAR | Bradley | Demoted to reserve roster | | | Before |
| 9/4/2010 | TEW | Patton | Demoted to reserve roster | | | Before |
| 9/5/2010 | CIN | Fowler | Promoted to active roster | | | Before |
| 9/5/2010 | CIN | Vargas,J | Placed on Injured List | | 9/5/2010 | Before |
| 9/5/2010 | CIN | Young,E | Activated from Injured List | | | Before |
| 9/6/2010 | CTW | Buchholz,C | Demoted to reserve roster | | | Before |
| 9/8/2010 | CTW | Morneau | Demoted to reserve roster | | | Before |
| 9/8/2010 | NEP | Harrell | Demoted to reserve roster | | | Before |
| 9/8/2010 | NEP | Morrow | Promoted to active roster | | | Before |
| 9/9/2010 | AST | Gomez,J | Placed on Injured List | | 9/5/2010 | Before |
| 9/9/2010 | AST | Lowrie | Promoted to active roster | | | Before |
| 9/9/2010 | CEN | Guerrier | Demoted to reserve roster | | | Before |
| 9/9/2010 | CIN | Frieri | Demoted to reserve roster | | | Before |
| 9/10/2010 | CEN | Dickey | Activated from Injured List | | | Before |
| 9/10/2010 | CEN | Maldonado | Demoted to reserve roster | | | Before |
| 9/10/2010 | CTW | Bruce | Demoted to reserve roster | | | Before |
| 9/10/2010 | CTW | Morales,K | Demoted to reserve roster | | | Before |
| 9/10/2010 | CTW | Saito | Demoted to reserve roster | | | Before |
| 9/10/2010 | CTW | Venable | Demoted to reserve roster | | | Before |
| 9/10/2010 | GAR | Park | Demoted to reserve roster | | | Before |
| 9/10/2010 | GAR | Rodney | Promoted to active roster | | | Before |
| 9/10/2010 | TEW | Gregerson | Demoted to reserve roster | | | Before |
| 9/12/2010 | TEW | Adams | Demoted to reserve roster | | | Before |
| 9/13/2010 | AST | Tallet | Demoted to reserve roster | | | Before |
| 9/13/2010 | BAR | Choate | Demoted to reserve roster | | | Before |
| 9/13/2010 | BAR | Choate | Promoted to active roster | | | Before |
| 9/13/2010 | BAR | Correia | Activated from Injured List | | | Before |
| 9/13/2010 | BAR | Escalona | Promoted to active roster | | | Before |
| 9/13/2010 | BAR | Hawkins | Demoted to reserve roster | | | Before |
| 9/13/2010 | BAR | Morales,F | Demoted to reserve roster | | | Before |
| 9/13/2010 | BAR | Morgan | Demoted to reserve roster | | | Before |
| 9/13/2010 | BAR | Varvaro | Promoted to active roster | | | Before |
| 9/13/2010 | CEN | Burrell | Demoted to reserve roster | | | Before |
| 9/13/2010 | CIN | Elbert | Demoted to reserve roster | | | Before |
| 9/13/2010 | CIN | Perkins | Demoted to reserve roster | | | Before |
| 9/13/2010 | TEW | Latos | Activated from Injured List | | | Before |
| 9/14/2010 | BBG | Hanigan | Demoted to reserve roster | | | Before |
| 9/14/2010 | CTW | Lyon | Demoted to reserve roster | | | Before |
| 9/14/2010 | CTW | Moss | Demoted to reserve roster | | | Before |
| 9/15/2010 | BBG | Johnson,Jo | Demoted to reserve roster | | | Before |
| 9/15/2010 | BBG | Johnson,Ro | Promoted to active roster | | | Before |
| 9/16/2010 | AST | Huff,D | Demoted to reserve roster | | | Before |
| 9/16/2010 | NEP | Baxter | Promoted to active roster | | | Before |
| 9/17/2010 | BBG | Tulowitzki | Demoted to reserve roster | | | Before |
| 9/18/2010 | BBG | Pujols | Demoted to reserve roster | | | Before |
| 9/18/2010 | NEP | Breslow | Demoted to reserve roster | | | Before |
| 9/19/2010 | CIN | Alvarez | Demoted to reserve roster | | | Before |
| 9/19/2010 | CTW | Marmol | Demoted to reserve roster | | | Before |
| 9/19/2010 | GAR | Manship | Demoted to reserve roster | | | Before |
| 9/19/2010 | GAR | Neshek | Promoted to active roster | | | Before |
| 9/21/2010 | AST | Richard | Demoted to reserve roster | | | Before |
| 9/21/2010 | BBG | Humber | Demoted to reserve roster | | | Before |
| 9/21/2010 | CIN | Vargas,J | Activated from Injured List | | | Before |
| 9/21/2010 | CTW | O'Day | Demoted to reserve roster | | | Before |
| 9/21/2010 | NEP | Kubel | Activated from Injured List | | | Before |
| 9/22/2010 | AST | Gomez,J | Activated from Injured List | | | Before |
| 9/22/2010 | BAR | Morales,F | Promoted to active roster | | | Before |
| 9/22/2010 | BAR | Ramos,C | Demoted to reserve roster | | | Before |
| 9/22/2010 | CTW | Jimenez | Demoted to reserve roster | | | Before |
| 9/22/2010 | CTW | Saito | Promoted to active roster | | | Before |
| 9/23/2010 | BAR | Kelley | Promoted to active roster | | | Before |
| 9/23/2010 | BAR | Minor | Promoted to active roster | | | Before |
| 9/23/2010 | BAR | Torres,C | Promoted to active roster | | | Before |
| 9/23/2010 | BAR | Veras | Demoted to reserve roster | | | Before |
| 9/23/2010 | BBG | Betancourt,R | Demoted to reserve roster | | | Before |
| 9/23/2010 | CIN | Logan | Demoted to reserve roster | | | Before |
| 9/23/2010 | NEP | Baxter | Demoted to reserve roster | | | Before |
| 9/24/2010 | BAR | Boesch | Demoted to reserve roster | | | Before |
| 9/24/2010 | BBG | Oliver,D | Demoted to reserve roster | | | Before |
| 9/24/2010 | CEN | Revere | Demoted to reserve roster | | | Before |
| 9/24/2010 | CIN | Young,E | Demoted to reserve roster | | | Before |
| 9/25/2010 | BAR | Escalona | Demoted to reserve roster | | | Before |
| 9/25/2010 | CTW | Johnson,K | Demoted to reserve roster | | | Before |
| 9/25/2010 | DLM | Lowe,M | Demoted to reserve roster | | | Before |
| 9/25/2010 | TEW | Meek | Demoted to reserve roster | | | Before |
| 9/26/2010 | AST | Wood,Br | Demoted to reserve roster | | | Before |