| Transactions |
| Date | Team | Player | Type | OthTm | EffDate | When |
| 4/2/2008 | CBB | Hernandez,Fel | Demoted to reserve roster | | | Before |
| 4/2/2008 | CBB | Paulino | Promoted to active roster | | | Before |
| 4/2/2008 | HAR | Phillips,B | Placed on disabled list | | 4/2/2008 | Before |
| 4/2/2008 | HAR | Velez | Promoted to active roster | | | Before |
| 4/5/2008 | CBB | Hernandez,Fel | Promoted to active roster | | | Before |
| 4/5/2008 | CBB | Paulino | Demoted to reserve roster | | | Before |
| 4/6/2008 | CBB | Kershaw | Placed on disabled list | | 4/5/2008 | Before |
| 4/6/2008 | CBB | Moehler | Promoted to active roster | | | Before |
| 4/6/2008 | SOI | Francis | Demoted to reserve roster | | | Before |
| 4/6/2008 | SOI | Saltalamacchia | Promoted to active roster | | | Before |
| 4/8/2008 | BAR | Duchscherer | Demoted to reserve roster | | | Before |
| 4/8/2008 | BAR | Rodriguez,L | Demoted to reserve roster | | | Before |
| 4/8/2008 | BAR | Tejada,M | Promoted to active roster | | | Before |
| 4/8/2008 | BAR | Vargas | Promoted to active roster | | | Before |
| 4/8/2008 | GAR | Alou | Demoted to reserve roster | | | Before |
| 4/8/2008 | GAR | Posada | Placed on disabled list | | 4/7/2008 | Before |
| 4/8/2008 | GAR | Rabelo | Promoted to active roster | | | Before |
| 4/8/2008 | GAR | Ramirez,Max | Promoted to active roster | | | Before |
| 4/9/2008 | RYS | Matsui,H | Placed on disabled list | | 4/9/2008 | Before |
| 4/9/2008 | SOI | Francis | Promoted to active roster | | | Before |
| 4/9/2008 | SOI | Saltalamacchia | Demoted to reserve roster | | | Before |
| 4/10/2008 | CIN | Elbert | Demoted to reserve roster | | | Before |
| 4/10/2008 | CIN | Guerrier | Promoted to active roster | | | Before |
| 4/10/2008 | NYD | Church | Demoted to reserve roster | | | Before |
| 4/10/2008 | NYD | Thomas,C | Promoted to active roster | | | Before |
| 4/10/2008 | RYS | Ross,C | Promoted to active roster | | | Before |
| 4/11/2008 | CIO | Carpenter,C | Demoted to reserve roster | | | Before |
| 4/11/2008 | CIO | Tejeda,R | Promoted to active roster | | | Before |
| 4/12/2008 | FDH | Cervelli | Demoted to reserve roster | | | Before |
| 4/12/2008 | FDH | Towles | Promoted to active roster | | | Before |
| 4/12/2008 | TEW | Estrada,M | Placed on disabled list | | 4/12/2008 | Before |
| 4/12/2008 | TEW | Meek | Promoted to active roster | | | Before |
| 4/13/2008 | CEN | Redmond | Promoted to active roster | | | Before |
| 4/13/2008 | CEN | Scutaro | Placed on disabled list | | 4/12/2008 | Before |
| 4/13/2008 | CIN | Farnsworth | Demoted to reserve roster | | | Before |
| 4/13/2008 | CIN | Frandsen | Demoted to reserve roster | | | Before |
| 4/13/2008 | CIN | Logan | Promoted to active roster | | | Before |
| 4/13/2008 | CIN | Lopez,F | Promoted to active roster | | | Before |
| 4/13/2008 | CIN | Perez,C | Demoted to reserve roster | | | Before |
| 4/13/2008 | CIN | Rauch | Promoted to active roster | | | Before |
| 4/13/2008 | FDH | Ellis,A | Demoted to reserve roster | | | Before |
| 4/13/2008 | FDH | Treanor | Promoted to active roster | | | Before |
| 4/14/2008 | AST | Brown,E | Promoted to active roster | | | Before |
| 4/14/2008 | AST | Thames | Demoted to reserve roster | | | Before |
| 4/14/2008 | BBG | Aceves | Promoted to active roster | | | Before |
| 4/14/2008 | BBG | Feldman | Promoted to active roster | | | Before |
| 4/14/2008 | BBG | Harrison | Placed on disabled list | | 4/13/2008 | Before |
| 4/14/2008 | BBG | Johnson,Jo | Placed on disabled list | | 4/14/2008 | Before |
| 4/14/2008 | CIN | Burnett,A | Promoted to active roster | | | Before |
| 4/14/2008 | CIN | Simon | Demoted to reserve roster | | | Before |
| 4/15/2008 | RMO | Ponson | Demoted to reserve roster | | | Before |
| 4/15/2008 | RMO | Wang | Promoted to active roster | | | Before |
| 4/17/2008 | CIN | Miller,C | Demoted to reserve roster | | | Before |
| 4/17/2008 | CIN | Pena,B | Promoted to active roster | | | Before |
| 4/17/2008 | NEP | Brignac | Promoted to active roster | | | Before |
| 4/17/2008 | NEP | Uggla | Placed on disabled list | | 4/15/2008 | Before |
| 4/18/2008 | GAR | Alou | Promoted to active roster | | | Before |
| 4/18/2008 | GAR | Ramirez,Max | Demoted to reserve roster | | | Before |
| 4/19/2008 | BBG | Aceves | Placed on disabled list | | 4/19/2008 | Before |
| 4/19/2008 | BBG | Correia | Promoted to active roster | | | Before |
| 4/19/2008 | BRK | Gregg | Promoted to active roster | | | Before |
| 4/19/2008 | BRK | Harden | Placed on disabled list | | 4/19/2008 | Before |
| 4/19/2008 | CIN | Fowler | Demoted to reserve roster | | | Before |
| 4/19/2008 | CIN | Lewis,F | Promoted to active roster | | | Before |
| 4/20/2008 | AST | Litsch | Demoted to reserve roster | | | Before |
| 4/20/2008 | AST | Ramirez,Ed | Demoted to reserve roster | | | Before |
| 4/20/2008 | AST | Shields,S | Promoted to active roster | | | Before |
| 4/20/2008 | AST | Moss | Traded away | HAR | | After |
| 4/20/2008 | AST | Shields,S | Acquired via trade | HAR | | After |
| 4/20/2008 | AST | Springer | Acquired via trade | HAR | | After |
| 4/20/2008 | CIN | Kottaras | Demoted to reserve roster | | | Before |
| 4/20/2008 | CIN | Molina,B | Promoted to active roster | | | Before |
| 4/20/2008 | HAR | Moss | Acquired via trade | AST | | After |
| 4/20/2008 | HAR | Shields,S | Traded away | AST | | After |
| 4/20/2008 | HAR | Springer | Traded away | AST | | After |
| 4/22/2008 | CIN | Byrdak | Promoted to active roster | | | Before |
| 4/22/2008 | CIN | Cordero,F | Promoted to active roster | | | Before |
| 4/22/2008 | CIN | Farnsworth | Promoted to active roster | | | Before |
| 4/22/2008 | CIN | Guerrier | Demoted to reserve roster | | | Before |
| 4/22/2008 | CIN | Logan | Demoted to reserve roster | | | Before |
| 4/22/2008 | CIN | Rauch | Demoted to reserve roster | | | Before |
| 4/22/2008 | NEP | Brignac | Demoted to reserve roster | | | Before |
| 4/23/2008 | NEP | McGehee | Promoted to active roster | | | Before |
| 4/24/2008 | CTW | Hall,B | Promoted to active roster | | | Before |
| 4/24/2008 | CTW | Maybin | Demoted to reserve roster | | | Before |
| 4/24/2008 | TEW | Hensley | Promoted to active roster | | | Before |
| 4/24/2008 | TEW | Meek | Placed on disabled list | | 4/23/2008 | Before |
| 4/25/2008 | BRK | Clippard | Demoted to reserve roster | | | Before |
| 4/25/2008 | BRK | Counsell | Promoted to active roster | | | Before |
| 4/25/2008 | BRK | McCarthy | Promoted to active roster | | | Before |
| 4/25/2008 | BRK | Zimmerman | Placed on disabled list | | 4/23/2008 | Before |
| 4/25/2008 | CIN | Cueto | Demoted to reserve roster | | | Before |
| 4/25/2008 | CIN | Floyd,G | Promoted to active roster | | | Before |
| 4/25/2008 | HAR | Moss | Promoted to active roster | | | Before |
| 4/25/2008 | HAR | Phillips,B | Activated from disabled list | | | Before |
| 4/25/2008 | HAR | Velez | Demoted to reserve roster | | | Before |
| 4/26/2008 | AST | Fontenot | Placed on disabled list | | 4/26/2008 | Before |
| 4/26/2008 | AST | Hernandez,A | Promoted to active roster | | | Before |
| 4/26/2008 | BAR | Duchscherer | Promoted to active roster | | | Before |
| 4/26/2008 | BAR | Vargas | Demoted to reserve roster | | | Before |
| 4/26/2008 | BBG | Oliver | Placed on disabled list | | 4/24/2008 | Before |
| 4/26/2008 | BBG | Rodney | Promoted to active roster | | | Before |
| 4/26/2008 | CIO | Calero | Promoted to active roster | | | Before |
| 4/26/2008 | CIO | Hill,A | Placed on disabled list | | 4/26/2008 | Before |
| 4/26/2008 | GAR | DeJesus | Placed on disabled list | | 4/24/2008 | Before |
| 4/26/2008 | GAR | Mather | Promoted to active roster | | | Before |
| 4/27/2008 | CEN | Redmond | Demoted to reserve roster | | | Before |
| 4/27/2008 | CEN | Scutaro | Activated from disabled list | | | Before |
| 4/28/2008 | BBG | Feldman | Demoted to reserve roster | | | Before |
| 4/28/2008 | BBG | Harrison | Activated from disabled list | | | Before |
| 4/29/2008 | BBG | Correia | Demoted to reserve roster | | | Before |
| 4/29/2008 | BBG | Johnson,Jo | Activated from disabled list | | | Before |
| 4/29/2008 | CIN | Chavez,R | Promoted to active roster | | | Before |
| 4/29/2008 | CIN | Pena,B | Demoted to reserve roster | | | Before |
| 4/30/2008 | CIN | Kendrick,K | Promoted to active roster | | | Before |
| 4/30/2008 | CIN | Lopez,Jo | Promoted to active roster | | | Before |
| 4/30/2008 | CIN | Valbuena | Demoted to reserve roster | | | Before |
| 4/30/2008 | CIN | Villanueva | Demoted to reserve roster | | | Before |
| 4/30/2008 | GAR | Guardado | Promoted to active roster | | | Before |
| 4/30/2008 | GAR | Posada | Activated from disabled list | | | Before |
| 4/30/2008 | GAR | Rabelo | Demoted to reserve roster | | | Before |
| 4/30/2008 | GAR | Saito | Demoted to reserve roster | | | Before |
| 4/30/2008 | NEP | McGehee | Demoted to reserve roster | | | Before |
| 4/30/2008 | NEP | Uggla | Activated from disabled list | | | Before |
| 4/30/2008 | PHI | Price | Demoted to reserve roster | | | Before |
| 5/1/2008 | CBB | Looper | Demoted to reserve roster | | | Before |
| 5/1/2008 | CBB | Paulino | Promoted to active roster | | | Before |
| 5/1/2008 | PHI | Gallardo | Promoted to active roster | | | Before |
| 5/1/2008 | PHI | Marcum | Demoted to reserve roster | | | Before |
| 5/1/2008 | PHI | Ramirez,RS | Promoted to active roster | | | Before |
| 5/2/2008 | BBG | Feldman | Promoted to active roster | | | Before |
| 5/2/2008 | BBG | Kennedy,I | Demoted to reserve roster | | | Before |
| 5/2/2008 | HAR | Heilman | Promoted to active roster | | | Before |
| 5/2/2008 | HAR | Ohlendorf | Placed on disabled list | | 5/2/2008 | Before |
| 5/3/2008 | CBB | Kershaw | Activated from disabled list | | | Before |
| 5/3/2008 | CBB | Moehler | Demoted to reserve roster | | | Before |
| 5/3/2008 | CIN | Farnsworth | Demoted to reserve roster | | | Before |
| 5/3/2008 | CIN | Guerrier | Promoted to active roster | | | Before |
| 5/3/2008 | GAR | Pujols | Placed on disabled list | | 5/3/2008 | Before |
| 5/3/2008 | GAR | Thomas,F | Promoted to active roster | | | Before |
| 5/3/2008 | NEP | Bulger | Demoted to reserve roster | | | Before |
| 5/3/2008 | NEP | Outman | Promoted to active roster | | | Before |
| 5/4/2008 | GAR | Pelfrey | Demoted to reserve roster | | | Before |
| 5/4/2008 | GAR | Reyes,An | Promoted to active roster | | | Before |
| 5/5/2008 | CTW | Soriano,R | Demoted to reserve roster | | | Before |
| 5/5/2008 | CTW | Van Benschoten | Promoted to active roster | | | Before |
| 5/5/2008 | RYS | Smith,S | Demoted to reserve roster | | | Before |
| 5/7/2008 | CBB | Harang | Demoted to reserve roster | | | Before |
| 5/7/2008 | CBB | Looper | Promoted to active roster | | | Before |
| 5/7/2008 | CIN | Cueto | Promoted to active roster | | | Before |
| 5/7/2008 | CIN | Gonzalez,G | Demoted to reserve roster | | | Before |
| 5/7/2008 | FDH | Hernandez,Li | Promoted to active roster | | | Before |
| 5/7/2008 | FDH | Karstens | Demoted to reserve roster | | | Before |
| 5/8/2008 | CIN | Byrdak | Demoted to reserve roster | | | Before |
| 5/8/2008 | CIN | Logan | Promoted to active roster | | | Before |
| 5/8/2008 | CTW | Garcia,F | Promoted to active roster | | | Before |
| 5/8/2008 | CTW | Garcia,J | Demoted to reserve roster | | | Before |
| 5/8/2008 | RYS | Braden | Promoted to active roster | | | Before |
| 5/8/2008 | RYS | Davis,R | Promoted to active roster | | | Before |
| 5/8/2008 | RYS | Happ | Demoted to reserve roster | | | Before |
| 5/8/2008 | SOI | MacDougal | Demoted to reserve roster | | | Before |
| 5/8/2008 | SOI | Pauley | Promoted to active roster | | | Before |
| 5/9/2008 | ATM | Garciaparra | Promoted to active roster | | | Before |
| 5/9/2008 | ATM | Santiago | Demoted to reserve roster | | | Before |
| 5/9/2008 | BRK | Baker,Jo | Demoted to reserve roster | | | Before |
| 5/9/2008 | BRK | Counsell | Demoted to reserve roster | | | Before |
| 5/9/2008 | BRK | Gregg | Demoted to reserve roster | | | Before |
| 5/9/2008 | BRK | Harden | Activated from disabled list | | | Before |
| 5/9/2008 | BRK | Snyder,C | Promoted to active roster | | | Before |
| 5/9/2008 | BRK | Zimmerman | Activated from disabled list | | | Before |
| 5/9/2008 | CIN | Cordero,F | Demoted to reserve roster | | | Before |
| 5/9/2008 | CIN | Perez,C | Promoted to active roster | | | Before |
| 5/9/2008 | GAR | Alou | Demoted to reserve roster | | | Before |
| 5/9/2008 | GAR | DeJesus | Activated from disabled list | | | Before |
| 5/9/2008 | GAR | Mock | Promoted to active roster | | | Before |
| 5/9/2008 | GAR | Ryan,BJ | Placed on disabled list | | 5/9/2008 | Before |
| 5/10/2008 | FDH | Patterson,C | Promoted to active roster | | | Before |
| 5/10/2008 | FDH | Quiroz | Demoted to reserve roster | | | Before |
| 5/11/2008 | CIO | Hill,A | Activated from disabled list | | | Before |
| 5/11/2008 | CIO | Ross,D | Demoted to reserve roster | | | Before |
| 5/12/2008 | CTW | Hall,B | Placed on disabled list | | 5/12/2008 | Before |
| 5/12/2008 | CTW | Pennington | Promoted to active roster | | | Before |
| 5/12/2008 | FDH | Bailey,H | Demoted to reserve roster | | | Before |
| 5/12/2008 | FDH | Dickey | Promoted to active roster | | | Before |
| 5/13/2008 | CBB | Harang | Promoted to active roster | | | Before |
| 5/13/2008 | CBB | Paulino | Demoted to reserve roster | | | Before |
| 5/14/2008 | CIO | Padilla | Promoted to active roster | | | Before |
| 5/14/2008 | CIO | Tejeda,R | Demoted to reserve roster | | | Before |
| 5/14/2008 | FDH | Belisle | Demoted to reserve roster | | | Before |
| 5/14/2008 | FDH | Chavez,J | Promoted to active roster | | | Before |
| 5/15/2008 | CIN | Sanchez,A | Demoted to reserve roster | | | Before |
| 5/15/2008 | CIN | Villanueva | Promoted to active roster | | | Before |
| 5/15/2008 | NEP | Galarraga | Demoted to reserve roster | | | Before |
| 5/15/2008 | NEP | Outman | Demoted to reserve roster | | | Before |
| 5/15/2008 | NEP | Pavano | Promoted to active roster | | | Before |
| 5/15/2008 | NEP | Wuertz | Promoted to active roster | | | Before |
| 5/15/2008 | RMO | Dillon | Demoted to reserve roster | | | Before |
| 5/15/2008 | RMO | Rivas | Promoted to active roster | | | Before |
| 5/16/2008 | AST | Brown,E | Demoted to reserve roster | | | Before |
| 5/16/2008 | AST | Thames | Promoted to active roster | | | Before |
| 5/16/2008 | BBG | Hanigan | Demoted to reserve roster | | | Before |
| 5/16/2008 | BBG | Torrealba | Promoted to active roster | | | Before |
| 5/16/2008 | FDH | Morton,Ch | Placed on disabled list | | 5/16/2008 | Before |
| 5/16/2008 | FDH | Robertson,N | Promoted to active roster | | | Before |
| 5/16/2008 | SOI | Rodriguez,A | Placed on disabled list | | 5/14/2008 | Before |
| 5/17/2008 | NEP | Outman | Promoted to active roster | | | Before |
| 5/17/2008 | NEP | Peavy | Placed on disabled list | | 5/17/2008 | Before |
| 5/18/2008 | BBG | Aceves | Activated from disabled list | | | Before |
| 5/18/2008 | BBG | Marshall | Demoted to reserve roster | | | Before |
| 5/18/2008 | FDH | Loe | Promoted to active roster | | | Before |
| 5/18/2008 | FDH | Romo | Demoted to reserve roster | | | Before |
| 5/18/2008 | GAR | Pujols | Activated from disabled list | | | Before |
| 5/18/2008 | GAR | Thomas,F | Demoted to reserve roster | | | Before |
| 5/18/2008 | SOI | Saltalamacchia | Promoted to active roster | | | Before |
| 5/18/2008 | SOI | Sandoval,P | Demoted to reserve roster | | | Before |
| 5/19/2008 | HAR | Boggs,M | Demoted to reserve roster | | | Before |
| 5/19/2008 | HAR | Gaudin | Promoted to active roster | | | Before |
| 5/19/2008 | HAR | Lowe,M | Promoted to active roster | | | Before |
| 5/19/2008 | HAR | Samardzija | Demoted to reserve roster | | | Before |
| 5/20/2008 | BBG | Correia | Promoted to active roster | | | Before |
| 5/20/2008 | BBG | Weaver | Placed on disabled list | | 5/19/2008 | Before |
| 5/21/2008 | AST | Langerhans | Promoted to active roster | | | Before |
| 5/21/2008 | AST | LaRoche,Ad | Demoted to reserve roster | | | Before |
| 5/21/2008 | RYS | Scherzer | Demoted to reserve roster | | | Before |
| 5/21/2008 | SOI | Pauley | Demoted to reserve roster | | | Before |
| 5/21/2008 | SOI | Silva | Promoted to active roster | | | Before |
| 5/24/2008 | AST | Holm | Acquired via trade | NYD | | After |
| 5/24/2008 | AST | Jacobs | Acquired via trade | NYD | | After |
| 5/24/2008 | AST | Nieves | Traded away | NYD | | After |
| 5/24/2008 | CIN | Cordero,F | Promoted to active roster | | | Before |
| 5/24/2008 | CIN | Logan | Demoted to reserve roster | | | Before |
| 5/24/2008 | CIN | Perez,C | Demoted to reserve roster | | | Before |
| 5/24/2008 | CIN | Rauch | Promoted to active roster | | | Before |
| 5/24/2008 | CTW | Bannister | Demoted to reserve roster | | | Before |
| 5/24/2008 | CTW | LaRue | Promoted to active roster | | | Before |
| 5/24/2008 | GAR | Cruz,Ju | Demoted to reserve roster | | | Before |
| 5/24/2008 | GAR | Ryan,BJ | Activated from disabled list | | | Before |
| 5/24/2008 | NYD | Church | Promoted to active roster | | | Before |
| 5/24/2008 | NYD | Macri | Demoted to reserve roster | | | Before |
| 5/24/2008 | NYD | Holm | Traded away | AST | | After |
| 5/24/2008 | NYD | Jacobs | Traded away | AST | | After |
| 5/24/2008 | NYD | Nieves | Acquired via trade | AST | | After |
| 5/24/2008 | PHI | Gallardo | Demoted to reserve roster | | | Before |
| 5/24/2008 | RYS | Coffey | Demoted to reserve roster | | | Before |
| 5/24/2008 | RYS | Durbin | Promoted to active roster | | | Before |
| 5/24/2008 | RYS | Zito | Promoted to active roster | | | Before |
| 5/25/2008 | AST | Jacobs | Promoted to active roster | | | Before |
| 5/25/2008 | AST | Langerhans | Demoted to reserve roster | | | Before |
| 5/25/2008 | CTW | Badenhop | Demoted to reserve roster | | | Before |
| 5/25/2008 | CTW | Reynolds,G | Promoted to active roster | | | Before |
| 5/25/2008 | FDH | Cotts | Demoted to reserve roster | | | Before |
| 5/25/2008 | FDH | Olson | Promoted to active roster | | | Before |
| 5/25/2008 | NEP | Geary | Demoted to reserve roster | | | Before |
| 5/25/2008 | NEP | Nelson,J | Promoted to active roster | | | Before |
| 5/26/2008 | BBG | Oliver | Activated from disabled list | | | Before |
| 5/26/2008 | BBG | Ruiz,R | Demoted to reserve roster | | | Before |
| 5/26/2008 | BRK | Clippard | Promoted to active roster | | | Before |
| 5/26/2008 | BRK | McCarthy | Demoted to reserve roster | | | Before |
| 5/26/2008 | CIN | Byrdak | Promoted to active roster | | | Before |
| 5/26/2008 | CIN | Choo | Demoted to reserve roster | | | Before |
| 5/26/2008 | CIN | Farnsworth | Promoted to active roster | | | Before |
| 5/26/2008 | CIN | Willingham | Demoted to reserve roster | | | Before |
| 5/26/2008 | RYS | Guzman,C | Demoted to reserve roster | | | Before |
| 5/26/2008 | RYS | Uribe | Promoted to active roster | | | Before |
| 5/27/2008 | AST | Jackson,E | Demoted to reserve roster | | | Before |
| 5/27/2008 | AST | Litsch | Promoted to active roster | | | Before |
| 5/27/2008 | CTW | Bannister | Promoted to active roster | | | Before |
| 5/27/2008 | CTW | LaRue | Demoted to reserve roster | | | Before |
| 5/27/2008 | NEP | Prado | Demoted to reserve roster | | | Before |
| 5/27/2008 | NEP | Salazar,O | Promoted to active roster | | | Before |
| 5/27/2008 | NYD | Arias,J | Promoted to active roster | | | Before |
| 5/27/2008 | NYD | Bailey,J | Demoted to reserve roster | | | Before |
| 5/28/2008 | CTW | Garcia,F | Demoted to reserve roster | | | Before |
| 5/28/2008 | CTW | Hall,B | Activated from disabled list | | | Before |
| 5/28/2008 | CTW | Taveras,W | Promoted to active roster | | | Before |
| 5/28/2008 | CTW | Venable | Demoted to reserve roster | | | Before |
| 5/28/2008 | RMO | Loaiza | Demoted to reserve roster | | | Before |
| 5/29/2008 | BBG | Humber | Promoted to active roster | | | Before |
| 5/29/2008 | BBG | Wilson,C | Demoted to reserve roster | | | Before |
| 5/29/2008 | PHI | Bako | Demoted to reserve roster | | | Before |
| 5/29/2008 | PHI | Burke,J | Promoted to active roster | | | Before |
| 5/29/2008 | PHI | Marcum | Promoted to active roster | | | Before |
| 5/29/2008 | PHI | Ramirez,RS | Demoted to reserve roster | | | Before |
| 5/29/2008 | PHI | Riggans | Promoted to active roster | | | Before |
| 5/29/2008 | PHI | Romero,J | Demoted to reserve roster | | | Before |
| 5/29/2008 | PHI | Speier,R | Promoted to active roster | | | Before |
| 5/29/2008 | RMO | Speier,J | Promoted to active roster | | | Before |
| 5/29/2008 | SOI | Andino | Promoted to active roster | | | Before |
| 5/29/2008 | SOI | Bonifacio | Demoted to reserve roster | | | Before |
| 5/29/2008 | SOI | Johnson,E | Promoted to active roster | | | Before |
| 5/30/2008 | AST | Fontenot | Activated from disabled list | | | Before |
| 5/30/2008 | AST | Hernandez,A | Demoted to reserve roster | | | Before |
| 5/31/2008 | GAR | Pelfrey | Promoted to active roster | | | Before |
| 5/31/2008 | GAR | Reyes,An | Demoted to reserve roster | | | Before |
| 6/1/2008 | BBG | Konerko | Placed on disabled list | | 6/1/2008 | Before |
| 6/1/2008 | BBG | Montero | Demoted to reserve roster | | | Before |
| 6/1/2008 | BBG | Schneider | Promoted to active roster | | | Before |
| 6/1/2008 | BBG | Young,Dm | Promoted to active roster | | | Before |
| 6/1/2008 | NEP | Jurrjens | Demoted to reserve roster | | | Before |
| 6/1/2008 | NEP | Peavy | Activated from disabled list | | | Before |
| 6/2/2008 | CBB | Acosta | Promoted to active roster | | | Before |
| 6/2/2008 | CBB | Linebrink | Placed on disabled list | | 5/30/2008 | Before |
| 6/2/2008 | NEP | Galarraga | Promoted to active roster | | | Before |
| 6/2/2008 | NEP | Outman | Demoted to reserve roster | | | Before |
| 6/3/2008 | BBG | Aceves | Demoted to reserve roster | | | Before |
| 6/3/2008 | BBG | Weaver | Activated from disabled list | | | Before |
| 6/3/2008 | CTW | Callaspo | Demoted to reserve roster | | | Before |
| 6/3/2008 | CTW | Greene | Promoted to active roster | | | Before |
| 6/3/2008 | SOI | de la Rosa | Placed on disabled list | | 6/3/2008 | Before |
| 6/3/2008 | SOI | Gorzelanny | Promoted to active roster | | | Before |
| 6/4/2008 | ATM | Devine | Demoted to reserve roster | | | Before |
| 6/4/2008 | ATM | League | Promoted to active roster | | | Before |
| 6/4/2008 | FDH | Chavez,J | Demoted to reserve roster | | | Before |
| 6/4/2008 | FDH | Liz | Promoted to active roster | | | Before |
| 6/5/2008 | BRK | Clippard | Demoted to reserve roster | | | Before |
| 6/5/2008 | BRK | Coke | Promoted to active roster | | | Before |
| 6/5/2008 | PHI | German,F | Promoted to active roster | | | Before |
| 6/5/2008 | PHI | Rollins | Placed on disabled list | | 6/4/2008 | Before |
| 6/7/2008 | AST | Colon | Promoted to active roster | | | Before |
| 6/7/2008 | AST | Jackson,E | Promoted to active roster | | | Before |
| 6/7/2008 | AST | Litsch | Demoted to reserve roster | | | Before |
| 6/7/2008 | AST | Young,CR | Demoted to reserve roster | | | Before |
| 6/7/2008 | BBG | Hoffman | Promoted to active roster | | | Before |
| 6/7/2008 | BBG | Humber | Demoted to reserve roster | | | Before |
| 6/7/2008 | FDH | Denorfia | Demoted to reserve roster | | | Before |
| 6/7/2008 | FDH | Gload | Promoted to active roster | | | Before |
| 6/7/2008 | HAR | Liriano | Placed on disabled list | | 6/5/2008 | Before |
| 6/7/2008 | HAR | Stults | Promoted to active roster | | | Before |
| 6/7/2008 | SOI | Andino | Demoted to reserve roster | | | Before |
| 6/7/2008 | SOI | Rodriguez,A | Activated from disabled list | | | Before |
| 6/8/2008 | CEN | Furcal | Demoted to reserve roster | | | Before |
| 6/9/2008 | ATM | Kendall | Promoted to active roster | | | Before |
| 6/9/2008 | ATM | Napoli | Demoted to reserve roster | | | Before |
| 6/9/2008 | BBG | Castillo,J | Promoted to active roster | | | Before |
| 6/9/2008 | BBG | Zobrist | Demoted to reserve roster | | | Before |
| 6/9/2008 | NEP | Hunter,Tom | Promoted to active roster | | | Before |
| 6/9/2008 | NEP | Washburn | Demoted to reserve roster | | | Before |
| 6/10/2008 | FDH | Kendrick,H | Demoted to reserve roster | | | Before |
| 6/10/2008 | FDH | Pena,TF | Promoted to active roster | | | Before |
| 6/11/2008 | CEN | Berroa | Promoted to active roster | | | Before |
| 6/11/2008 | CEN | Izturis,M | Placed on disabled list | | 6/11/2008 | Before |
| 6/11/2008 | CEN | Redmond | Promoted to active roster | | | Before |
| 6/11/2008 | CIN | Logan | Promoted to active roster | | | Before |
| 6/11/2008 | CIN | Perkins | Demoted to reserve roster | | | Before |
| 6/13/2008 | AST | Brown,A | Demoted to reserve roster | | | Before |
| 6/13/2008 | AST | Carlyle | Promoted to active roster | | | Before |
| 6/13/2008 | CIO | Hill,A | Demoted to reserve roster | | | Before |
| 6/13/2008 | CIO | Ojeda | Promoted to active roster | | | Before |
| 6/14/2008 | ATM | Branyan | Demoted to reserve roster | | | Before |
| 6/14/2008 | ATM | Harris,W | Promoted to active roster | | | Before |
| 6/14/2008 | FDH | Jones,An | Promoted to active roster | | | Before |
| 6/14/2008 | FDH | Morse | Demoted to reserve roster | | | Before |
| 6/14/2008 | NEP | Giambi | Placed on disabled list | | 6/14/2008 | Before |
| 6/14/2008 | NEP | McGehee | Promoted to active roster | | | Before |
| 6/14/2008 | NEP | Salazar,O | Demoted to reserve roster | | | Before |
| 6/14/2008 | NEP | Sexson | Promoted to active roster | | | Before |
| 6/14/2008 | NYD | Ledezma | Promoted to active roster | | | Before |
| 6/14/2008 | NYD | Volstad | Demoted to reserve roster | | | Before |
| 6/14/2008 | RMO | Ayala | Promoted to active roster | | | Before |
| 6/14/2008 | RMO | Davis,D | Placed on disabled list | | 6/12/2008 | Before |
| 6/14/2008 | RMO | O'Day | Demoted to reserve roster | | | Before |
| 6/14/2008 | RMO | Ponson | Promoted to active roster | | | Before |
| 6/14/2008 | RYS | Zito | Placed on disabled list | | 6/6/2008 | Before |
| 6/15/2008 | BBG | Betemit | Demoted to reserve roster | | | Before |
| 6/15/2008 | BBG | Harrison | Demoted to reserve roster | | | Before |
| 6/15/2008 | BBG | Johnson,Jo | Demoted to reserve roster | | | Before |
| 6/15/2008 | BBG | Kent | Promoted to active roster | | | Before |
| 6/15/2008 | BBG | Olsen | Promoted to active roster | | | Before |
| 6/15/2008 | BBG | Perez,Ol | Promoted to active roster | | | Before |
| 6/15/2008 | CTW | Joyce | Demoted to reserve roster | | | Before |
| 6/15/2008 | CTW | LaRue | Promoted to active roster | | | Before |
| 6/15/2008 | CTW | Stewart,I | Promoted to active roster | | | Before |
| 6/15/2008 | CTW | Vizquel | Demoted to reserve roster | | | Before |
| 6/15/2008 | SOI | Andino | Promoted to active roster | | | Before |
| 6/15/2008 | SOI | Wilson,J | Placed on disabled list | | 6/15/2008 | Before |
| 6/16/2008 | AST | Brown,E | Promoted to active roster | | | Before |
| 6/16/2008 | AST | Jackson,E | Demoted to reserve roster | | | Before |
| 6/16/2008 | AST | Jacobs | Demoted to reserve roster | | | Before |
| 6/16/2008 | AST | LaRoche,Ad | Promoted to active roster | | | Before |
| 6/16/2008 | AST | Ramirez,Ed | Promoted to active roster | | | Before |
| 6/16/2008 | AST | Schoeneweis | Demoted to reserve roster | | | Before |
| 6/16/2008 | GAR | Cruz,Ju | Promoted to active roster | | | Before |
| 6/16/2008 | GAR | Mock | Demoted to reserve roster | | | Before |
| 6/16/2008 | GAR | Park | Promoted to active roster | | | Before |
| 6/16/2008 | GAR | Pelfrey | Demoted to reserve roster | | | Before |
| 6/16/2008 | GAR | Ryan,BJ | Demoted to reserve roster | | | Before |
| 6/16/2008 | GAR | Saito | Promoted to active roster | | | Before |
| 6/16/2008 | NEP | Jurrjens | Promoted to active roster | | | Before |
| 6/16/2008 | NEP | Pavano | Demoted to reserve roster | | | Before |
| 6/18/2008 | CIO | Guzman,A | Promoted to active roster | | | Before |
| 6/18/2008 | CIO | Masset | Demoted to reserve roster | | | Before |
| 6/18/2008 | FDH | Robertson,N | Placed on disabled list | | 6/18/2008 | Before |
| 6/18/2008 | FDH | Snell | Promoted to active roster | | | Before |
| 6/18/2008 | GAR | Mock | Promoted to active roster | | | Before |
| 6/18/2008 | GAR | Rivera,Ma | Demoted to reserve roster | | | Before |
| 6/18/2008 | SOI | de la Rosa | Activated from disabled list | | | Before |
| 6/18/2008 | SOI | Gorzelanny | Demoted to reserve roster | | | Before |
| 6/19/2008 | FDH | Loe | Demoted to reserve roster | | | Before |
| 6/19/2008 | FDH | Morton,Ch | Activated from disabled list | | | Before |
| 6/20/2008 | BBG | Betancourt,R | Demoted to reserve roster | | | Before |
| 6/20/2008 | BBG | Burnett,S | Promoted to active roster | | | Before |
| 6/20/2008 | CTW | LaRue | Demoted to reserve roster | | | Before |
| 6/20/2008 | CTW | LeBlanc | Promoted to active roster | | | Before |
| 6/20/2008 | FDH | Lyon | Demoted to reserve roster | | | Before |
| 6/20/2008 | FDH | Morton,Ch | Demoted to reserve roster | | | Before |
| 6/20/2008 | FDH | Parnell | Promoted to active roster | | | Before |
| 6/20/2008 | FDH | Suppan | Promoted to active roster | | | Before |
| 6/21/2008 | BRK | Baker,Jo | Promoted to active roster | | | Before |
| 6/21/2008 | BRK | Wolf | Demoted to reserve roster | | | Before |
| 6/21/2008 | CTW | Manning | Traded away | RYS | | After |
| 6/21/2008 | CTW | Milledge | Acquired via trade | RYS | | After |
| 6/21/2008 | HAR | Phillips,B | Placed on disabled list | | 6/20/2008 | Before |
| 6/21/2008 | HAR | Velez | Promoted to active roster | | | Before |
| 6/21/2008 | NEP | Buscher | Promoted to active roster | | | Before |
| 6/21/2008 | NEP | Hunter,Tom | Demoted to reserve roster | | | Before |
| 6/21/2008 | NEP | McGehee | Demoted to reserve roster | | | Before |
| 6/21/2008 | NEP | Niemann | Promoted to active roster | | | Before |
| 6/21/2008 | PHI | Masterson | Demoted to reserve roster | | | Before |
| 6/21/2008 | RYS | Zito | Activated from disabled list | | | Before |
| 6/21/2008 | RYS | Manning | Acquired via trade | CTW | | After |
| 6/21/2008 | RYS | Milledge | Traded away | CTW | | After |
| 6/22/2008 | CTW | Duke | Demoted to reserve roster | | | Before |
| 6/22/2008 | CTW | LaRue | Promoted to active roster | | | Before |
| 6/22/2008 | CTW | Milledge | Promoted to active roster | | | Before |
| 6/22/2008 | CTW | Span | Demoted to reserve roster | | | Before |
| 6/22/2008 | CTW | Crosby | Acquired via trade | HAR | | After |
| 6/22/2008 | CTW | Greene | Traded away | HAR | | After |
| 6/22/2008 | HAR | Crosby | Traded away | CTW | | After |
| 6/22/2008 | HAR | Greene | Acquired via trade | CTW | | After |
| 6/22/2008 | PHI | Garko | Promoted to active roster | | | Before |
| 6/22/2008 | PHI | Myers | Promoted to active roster | | | Before |
| 6/22/2008 | PHI | Riggans | Demoted to reserve roster | | | Before |
| 6/22/2008 | PHI | Rollins | Activated from disabled list | | | Before |
| 6/22/2008 | PHI | Speier,R | Demoted to reserve roster | | | Before |
| 6/22/2008 | SOI | Hill,R | Promoted to active roster | | | Before |
| 6/22/2008 | SOI | Ramirez,Ho | Demoted to reserve roster | | | Before |
| 6/24/2008 | NEP | Cantu | Promoted to active roster | | | Before |
| 6/24/2008 | NEP | Jeter | Placed on disabled list | | 6/24/2008 | Before |
| 6/24/2008 | RYS | Buchholz,C | Demoted to reserve roster | | | Before |
| 6/25/2008 | ATM | Mujica | Promoted to active roster | | | Before |
| 6/25/2008 | ATM | Santana,E | Placed on disabled list | | 6/25/2008 | Before |
| 6/25/2008 | CEN | Hairston,J | Acquired via trade | RYS | | After |
| 6/25/2008 | CIO | Calero | Demoted to reserve roster | | | Before |
| 6/25/2008 | CIO | Eyre | Promoted to active roster | | | Before |
| 6/25/2008 | CIO | Pagan | Promoted to active roster | | | Before |
| 6/25/2008 | CIO | Raburn | Demoted to reserve roster | | | Before |
| 6/25/2008 | RYS | Hairston,J | Traded away | CEN | | After |
| 6/25/2008 | TEW | Estrada,M | Activated from disabled list | | | Before |
| 6/25/2008 | TEW | Hensley | Demoted to reserve roster | | | Before |
| 6/25/2008 | TEW | Jenks | Promoted to active roster | | | Before |
| 6/25/2008 | TEW | Johnson,Ji | Demoted to reserve roster | | | Before |
| 6/26/2008 | CEN | Berroa | Demoted to reserve roster | | | Before |
| 6/26/2008 | CIO | Blum | Demoted to reserve roster | | | Before |
| 6/26/2008 | CIO | Ross,D | Promoted to active roster | | | Before |
| 6/26/2008 | CTW | LaRue | Demoted to reserve roster | | | Before |
| 6/26/2008 | FDH | Eaton | Promoted to active roster | | | Before |
| 6/26/2008 | FDH | Parnell | Demoted to reserve roster | | | Before |
| 6/26/2008 | RMO | Wang | Demoted to reserve roster | | | Before |
| 6/30/2008 | BBG | Konerko | Activated from disabled list | | | Before |
| 6/30/2008 | BBG | Young,Dm | Demoted to reserve roster | | | Before |
| 6/30/2008 | CIN | Farnsworth | Demoted to reserve roster | | | Before |
| 6/30/2008 | CIN | Perez,C | Promoted to active roster | | | Before |
| 6/30/2008 | CIN | Ramirez,Al | Demoted to reserve roster | | | Before |
| 6/30/2008 | CIN | Willingham | Promoted to active roster | | | Before |
| 6/30/2008 | CTW | Backe | Promoted to active roster | | | Before |
| 6/30/2008 | CTW | Batista | Promoted to active roster | | | Before |
| 6/30/2008 | CTW | Duke | Promoted to active roster | | | Before |
| 6/30/2008 | CTW | Reyes,JJ | Demoted to reserve roster | | | Before |
| 6/30/2008 | CTW | Van Benschoten | Demoted to reserve roster | | | Before |
| 6/30/2008 | NEP | Giambi | Activated from disabled list | | | Before |
| 6/30/2008 | NEP | Sexson | Demoted to reserve roster | | | Before |
| 6/30/2008 | NYD | Nieves | Promoted to active roster | | | Before |
| 6/30/2008 | NYD | Zaun | Placed on disabled list | | 6/27/2008 | Before |
| 7/1/2008 | BAR | Bedard | Promoted to active roster | | | Before |
| 7/1/2008 | BAR | Chamberlain | Placed on disabled list | | 7/1/2008 | Before |
| 7/1/2008 | BAR | Duchscherer | Demoted to reserve roster | | | Before |
| 7/1/2008 | BAR | Kinney | Promoted to active roster | | | Before |
| 7/1/2008 | CTW | Blevins | Demoted to reserve roster | | | Before |
| 7/1/2008 | CTW | Hill,S | Promoted to active roster | | | Before |
| 7/1/2008 | GAR | Cruz,Ju | Demoted to reserve roster | | | Before |
| 7/1/2008 | GAR | Guardado | Demoted to reserve roster | | | Before |
| 7/1/2008 | GAR | Hinshaw | Promoted to active roster | | | Before |
| 7/1/2008 | GAR | Seanez | Promoted to active roster | | | Before |
| 7/1/2008 | NEP | Bush | Demoted to reserve roster | | | Before |
| 7/1/2008 | NEP | Washburn | Promoted to active roster | | | Before |
| 7/2/2008 | ATM | Garciaparra | Demoted to reserve roster | | | Before |
| 7/2/2008 | ATM | Kapler | Promoted to active roster | | | Before |
| 7/2/2008 | NYD | Hu | Promoted to active roster | | | Before |
| 7/2/2008 | NYD | Thomas,C | Placed on disabled list | | 7/2/2008 | Before |
| 7/4/2008 | BAR | Carrasco | Demoted to reserve roster | | | Before |
| 7/4/2008 | BAR | Smoltz | Promoted to active roster | | | Before |
| 7/4/2008 | GAR | Cabrera,J | Promoted to active roster | | | Before |
| 7/4/2008 | GAR | Grudzielanek | Placed on disabled list | | 7/4/2008 | Before |
| 7/4/2008 | NEP | Benoit | Demoted to reserve roster | | | Before |
| 7/4/2008 | NEP | Geary | Promoted to active roster | | | Before |
| 7/5/2008 | BRK | Baker,Jo | Demoted to reserve roster | | | Before |
| 7/5/2008 | BRK | Balfour | Demoted to reserve roster | | | Before |
| 7/5/2008 | BRK | Bruney | Promoted to active roster | | | Before |
| 7/5/2008 | BRK | Hinckley | Promoted to active roster | | | Before |
| 7/5/2008 | BRK | Sanches,B | Promoted to active roster | | | Before |
| 7/5/2008 | BRK | Wagner | Demoted to reserve roster | | | Before |
| 7/5/2008 | CTW | Gomes,J | Demoted to reserve roster | | | Before |
| 7/5/2008 | CTW | Span | Promoted to active roster | | | Before |
| 7/5/2008 | GAR | Rivera,Ma | Promoted to active roster | | | Before |
| 7/5/2008 | GAR | Rivera,S | Demoted to reserve roster | | | Before |
| 7/5/2008 | GAR | Rivera,S | Promoted to active roster | | | Before |
| 7/5/2008 | GAR | Saito | Demoted to reserve roster | | | Before |
| 7/5/2008 | HAR | Burton | Demoted to reserve roster | | | Before |
| 7/5/2008 | HAR | Greene | Demoted to reserve roster | | | Before |
| 7/5/2008 | HAR | Greene | Promoted to active roster | | | Before |
| 7/5/2008 | HAR | Phillips,B | Activated from disabled list | | | Before |
| 7/5/2008 | HAR | Troncoso | Promoted to active roster | | | Before |
| 7/5/2008 | HAR | Velez | Placed on disabled list | | 6/23/2008 | Before |
| 7/6/2008 | SOI | Mendoza | Demoted to reserve roster | | | Before |
| 7/6/2008 | SOI | Ramirez,Ho | Promoted to active roster | | | Before |
| 7/7/2008 | BBG | Diaz,M | Demoted to reserve roster | | | Before |
| 7/7/2008 | BBG | Francoeur | Promoted to active roster | | | Before |
| 7/8/2008 | BBG | Ruggiano | Demoted to reserve roster | | | Before |
| 7/8/2008 | BBG | Young,Dm | Promoted to active roster | | | Before |
| 7/8/2008 | CTW | LaRue | Promoted to active roster | | | Before |
| 7/8/2008 | CTW | Olivo | Placed on disabled list | | 7/8/2008 | Before |
| 7/9/2008 | NEP | Bush | Promoted to active roster | | | Before |
| 7/9/2008 | NEP | Niemann | Demoted to reserve roster | | | Before |
| 7/9/2008 | SOI | Gorzelanny | Promoted to active roster | | | Before |
| 7/9/2008 | SOI | Ramirez,Ho | Demoted to reserve roster | | | Before |
| 7/10/2008 | AST | Gerut | Demoted to reserve roster | | | Before |
| 7/10/2008 | AST | Green | Promoted to active roster | | | Before |
| 7/10/2008 | AST | Murphy,Dan | Promoted to active roster | | | Before |
| 7/10/2008 | AST | Ziegler | Demoted to reserve roster | | | Before |
| 7/10/2008 | ATM | League | Demoted to reserve roster | | | Before |
| 7/10/2008 | ATM | Santana,E | Activated from disabled list | | | Before |
| 7/10/2008 | BBG | Beltre | Placed on disabled list | | 7/10/2008 | Before |
| 7/10/2008 | BBG | Zobrist | Promoted to active roster | | | Before |
| 7/10/2008 | CBB | Carlson | Demoted to reserve roster | | | Before |
| 7/10/2008 | CTW | Pennington | Demoted to reserve roster | | | Before |
| 7/10/2008 | CTW | Vizquel | Promoted to active roster | | | Before |
| 7/10/2008 | NEP | Cantu | Demoted to reserve roster | | | Before |
| 7/10/2008 | NEP | Jeter | Activated from disabled list | | | Before |
| 7/10/2008 | NYD | Baldelli | Demoted to reserve roster | | | Before |
| 7/10/2008 | NYD | Monroe | Promoted to active roster | | | Before |
| 7/11/2008 | CEN | Corpas | Promoted to active roster | | | Before |
| 7/11/2008 | CEN | Davies | Promoted to active roster | | | Before |
| 7/11/2008 | CEN | Isringhausen | Promoted to active roster | | | Before |
| 7/11/2008 | CEN | Oswalt | Placed on disabled list | | 7/11/2008 | Before |
| 7/11/2008 | CEN | Reyes,D | Demoted to reserve roster | | | Before |
| 7/11/2008 | CEN | Weathers | Demoted to reserve roster | | | Before |
| 7/11/2008 | CTW | Estrada,J | Promoted to active roster | | | Before |
| 7/11/2008 | CTW | LeBlanc | Demoted to reserve roster | | | Before |
| 7/11/2008 | CTW | Nippert | Demoted to reserve roster | | | Before |
| 7/11/2008 | CTW | Nippert | Promoted to active roster | | | Before |
| 7/11/2008 | CTW | Reyes,JJ | Promoted to active roster | | | Before |
| 7/11/2008 | CTW | Span | Demoted to reserve roster | | | Before |
| 7/12/2008 | BAR | Kinney | Demoted to reserve roster | | | Before |
| 7/12/2008 | CBB | Linebrink | Activated from disabled list | | | Before |
| 7/12/2008 | CEN | Izturis,M | Activated from disabled list | | | Before |
| 7/12/2008 | CEN | Redmond | Demoted to reserve roster | | | Before |
| 7/12/2008 | CEN | Zambrano | Placed on disabled list | | 7/12/2008 | Before |
| 7/12/2008 | CIN | Butler | Demoted to reserve roster | | | Before |
| 7/12/2008 | CIN | Byrdak | Demoted to reserve roster | | | Before |
| 7/12/2008 | CIN | Perkins | Promoted to active roster | | | Before |
| 7/12/2008 | CIN | Ramirez,Al | Promoted to active roster | | | Before |
| 7/12/2008 | CIO | Bartlett | Placed on disabled list | | 7/12/2008 | Before |
| 7/12/2008 | CIO | Blum | Promoted to active roster | | | Before |
| 7/12/2008 | CIO | Calero | Promoted to active roster | | | Before |
| 7/12/2008 | CIO | Guzman,A | Demoted to reserve roster | | | Before |
| 7/12/2008 | RMO | Davis,D | Activated from disabled list | | | Before |
| 7/12/2008 | RYS | Affeldt | Promoted to active roster | | | Before |
| 7/12/2008 | RYS | LaRoche,An | Promoted to active roster | | | Before |
| 7/12/2008 | RYS | Matsui,H | Activated from disabled list | | | Before |
| 7/12/2008 | RYS | Weeks | Placed on disabled list | | 7/2/2008 | Before |
| 7/12/2008 | TEW | Estrada,M | Demoted to reserve roster | | | Before |
| 7/12/2008 | TEW | Meek | Activated from disabled list | | | Before |
| 7/12/2008 | TEW | Ransom | Promoted to active roster | | | Before |
| 7/12/2008 | TEW | Youkilis | Placed on disabled list | | 7/12/2008 | Before |
| 7/13/2008 | BAR | Bedard | Traded away | CTW | | After |
| 7/13/2008 | BAR | Freel | Traded away | CTW | | After |
| 7/13/2008 | BAR | Schierholtz | Acquired via trade | CTW | | After |
| 7/13/2008 | BAR | Span | Acquired via trade | CTW | | After |
| 7/13/2008 | CIO | Bedard | Acquired via trade | CTW | | After |
| 7/13/2008 | CIO | Blanco,G | Traded away | CTW | | After |
| 7/13/2008 | CIO | Carmona | Traded away | CTW | | After |
| 7/13/2008 | CTW | Bedard | Traded away | CIO | | After |
| 7/13/2008 | CTW | Bedard | Acquired via trade | BAR | | After |
| 7/13/2008 | CTW | Blanco,G | Acquired via trade | CIO | | After |
| 7/13/2008 | CTW | Carmona | Acquired via trade | CIO | | After |
| 7/13/2008 | CTW | Freel | Acquired via trade | BAR | | After |
| 7/13/2008 | CTW | Schierholtz | Traded away | BAR | | After |
| 7/13/2008 | CTW | Span | Traded away | BAR | | After |
| 7/13/2008 | RYS | Frasor | Demoted to reserve roster | | | Before |
| 7/13/2008 | RYS | O'Flaherty | Promoted to active roster | | | Before |
| 7/14/2008 | BAR | Duchscherer | Promoted to active roster | | | Before |
| 7/14/2008 | BAR | Erstad | Demoted to reserve roster | | | Before |
| 7/14/2008 | BAR | Jimenez,C | Promoted to active roster | | | Before |
| 7/14/2008 | BAR | Kotchman | Demoted to reserve roster | | | Before |
| 7/14/2008 | BAR | Schierholtz | Promoted to active roster | | | Before |
| 7/14/2008 | BAR | Span | Promoted to active roster | | | Before |
| 7/14/2008 | CEN | Lopez,A | Promoted to active roster | | | Before |
| 7/14/2008 | CEN | Redding | Promoted to active roster | | | Before |
| 7/14/2008 | CEN | Snider | Demoted to reserve roster | | | Before |
| 7/14/2008 | CIO | Carmona | Promoted to active roster | | | Before |
| 7/14/2008 | CIO | Guillen,C | Promoted to active roster | | | Before |
| 7/14/2008 | CIO | Padilla | Demoted to reserve roster | | | Before |
| 7/14/2008 | CTW | Estrada,J | Demoted to reserve roster | | | Before |
| 7/14/2008 | CTW | Nippert | Demoted to reserve roster | | | Before |
| 7/14/2008 | GAR | McClung | Demoted to reserve roster | | | Before |
| 7/14/2008 | GAR | Rivera,S | Promoted to active roster | | | Before |
| 7/16/2008 | AST | Chen (AG) | Traded away | RMO | | After |
| 7/16/2008 | AST | Easley | Traded away | CIN | | After |
| 7/16/2008 | AST | Fuentes | Acquired via trade | RMO | | After |
| 7/16/2008 | AST | Hammel | Traded away | CTW | | After |
| 7/16/2008 | AST | Lopez,Jo | Acquired via trade | CIN | | After |
| 7/16/2008 | AST | Lugo | Acquired via trade | CIN | | After |
| 7/16/2008 | AST | Mota | Acquired via trade | CIN | | After |
| 7/16/2008 | AST | Stauffer (AG) | Traded away | RMO | | After |
| 7/16/2008 | AST | Thome | Acquired via trade | CTW | | After |
| 7/16/2008 | AST | Vargas (AG) | Traded away | CIN | | After |
| 7/16/2008 | BBG | Marmol | Traded away | CEN | | After |
| 7/16/2008 | BBG | Parra | Acquired via trade | CEN | | After |
| 7/16/2008 | CEN | Marmol | Acquired via trade | BBG | | After |
| 7/16/2008 | CEN | Parra | Traded away | BBG | | After |
| 7/16/2008 | CIN | Cairo | Demoted to reserve roster | | | Before |
| 7/16/2008 | CIN | Choo | Promoted to active roster | | | Before |
| 7/16/2008 | CIN | Easley | Acquired via trade | AST | | After |
| 7/16/2008 | CIN | Lopez,Jo | Traded away | AST | | After |
| 7/16/2008 | CIN | Lugo | Traded away | AST | | After |
| 7/16/2008 | CIN | Mota | Traded away | AST | | After |
| 7/16/2008 | CIN | Vargas (AG) | Acquired via trade | AST | | After |
| 7/16/2008 | CTW | Hammel | Acquired via trade | AST | | After |
| 7/16/2008 | CTW | Thome | Traded away | AST | | After |
| 7/16/2008 | HAR | Stults | Demoted to reserve roster | | | Before |
| 7/16/2008 | PHI | Arredondo | Demoted to reserve roster | | | Before |
| 7/16/2008 | PHI | German,F | Demoted to reserve roster | | | Before |
| 7/16/2008 | PHI | Romero,J | Promoted to active roster | | | Before |
| 7/16/2008 | PHI | Speier,R | Promoted to active roster | | | Before |
| 7/16/2008 | RMO | Chen (AG) | Acquired via trade | AST | | After |
| 7/16/2008 | RMO | Fuentes | Traded away | AST | | After |
| 7/16/2008 | RMO | Perez,R | Acquired via trade | SOI | | After |
| 7/16/2008 | RMO | Stauffer (AG) | Acquired via trade | AST | | After |
| 7/16/2008 | SOI | Perez,R | Traded away | RMO | | After |
| 7/17/2008 | AST | Beimel | Demoted to reserve roster | | | Before |
| 7/17/2008 | AST | Beimel | Promoted to active roster | | | Before |
| 7/17/2008 | AST | Beimel | Demoted to reserve roster | | | Before |
| 7/17/2008 | AST | Johnson,Re | Demoted to reserve roster | | | Before |
| 7/17/2008 | AST | LaRoche,Ad | Demoted to reserve roster | | | Before |
| 7/17/2008 | AST | Lugo | Promoted to active roster | | | Before |
| 7/17/2008 | AST | Thome | Demoted to reserve roster | | | Before |
| 7/17/2008 | BBG | Hanrahan | Promoted to active roster | | | Before |
| 7/17/2008 | CEN | Isringhausen | Demoted to reserve roster | | | Before |
| 7/17/2008 | CIN | Butler | Promoted to active roster | | | Before |
| 7/17/2008 | CTW | Hammel | Promoted to active roster | | | Before |
| 7/17/2008 | FDH | Gordon,A | Placed on disabled list | | 7/17/2008 | Before |
| 7/17/2008 | FDH | Mathis,J | Promoted to active roster | | | Before |
| 7/17/2008 | HAR | Ohlendorf | Activated from disabled list | | | Before |
| 7/17/2008 | NYD | Mahay | Demoted to reserve roster | | | Before |
| 7/17/2008 | NYD | Rhodes | Promoted to active roster | | | Before |
| 7/18/2008 | CIN | Chavez,R | Placed on disabled list | | 7/18/2008 | Before |
| 7/18/2008 | CIN | Farnsworth | Promoted to active roster | | | Before |
| 7/18/2008 | CIN | Guerrier | Demoted to reserve roster | | | Before |
| 7/18/2008 | CIN | Moeller | Promoted to active roster | | | Before |
| 7/18/2008 | HAR | Baek | Promoted to active roster | | | Before |
| 7/18/2008 | HAR | Cabrera,D | Promoted to active roster | | | Before |
| 7/18/2008 | HAR | Feliciano | Demoted to reserve roster | | | Before |
| 7/18/2008 | HAR | Hochevar | Demoted to reserve roster | | | Before |
| 7/18/2008 | HAR | Niese | Promoted to active roster | | | Before |
| 7/18/2008 | HAR | Putz | Demoted to reserve roster | | | Before |
| 7/18/2008 | SOI | Bonser | Promoted to active roster | | | Before |
| 7/19/2008 | AST | Lugo | Demoted to reserve roster | | | Before |
| 7/19/2008 | AST | Thome | Promoted to active roster | | | Before |
| 7/19/2008 | CIO | Howell | Demoted to reserve roster | | | Before |
| 7/19/2008 | CIO | Wright,J | Promoted to active roster | | | Before |
| 7/19/2008 | RYS | Albers | Promoted to active roster | | | Before |
| 7/19/2008 | RYS | Braden | Demoted to reserve roster | | | Before |
| 7/20/2008 | AST | Colon | Demoted to reserve roster | | | Before |
| 7/20/2008 | AST | Jackson,E | Promoted to active roster | | | Before |
| 7/21/2008 | CEN | Martinez,P | Traded away | SOI | | After |
| 7/21/2008 | CEN | Redding | Traded away | SOI | | After |
| 7/21/2008 | CEN | Vazquez,J | Acquired via trade | SOI | | After |
| 7/21/2008 | CIO | Calero | Demoted to reserve roster | | | Before |
| 7/21/2008 | CIO | Roberts,R | Promoted to active roster | | | Before |
| 7/21/2008 | NEP | Ohman | Promoted to active roster | | | Before |
| 7/21/2008 | NEP | Wuertz | Demoted to reserve roster | | | Before |
| 7/21/2008 | RYS | Jackson,C | Promoted to active roster | | | Before |
| 7/21/2008 | RYS | Ross,C | Placed on disabled list | | 7/20/2008 | Before |
| 7/21/2008 | RYS | Weeks | Activated from disabled list | | | Before |
| 7/21/2008 | RYS | Weeks | Demoted to reserve roster | | | Before |
| 7/21/2008 | SOI | Casilla,A | Demoted to reserve roster | | | Before |
| 7/21/2008 | SOI | Martinez,P | Promoted to active roster | | | Before |
| 7/21/2008 | SOI | Redding | Demoted to reserve roster | | | Before |
| 7/21/2008 | SOI | Wilson,J | Activated from disabled list | | | Before |
| 7/21/2008 | SOI | Martinez,P | Acquired via trade | CEN | | After |
| 7/21/2008 | SOI | Redding | Acquired via trade | CEN | | After |
| 7/21/2008 | SOI | Vazquez,J | Traded away | CEN | | After |
| 7/21/2008 | TEW | Buchholz,T | Demoted to reserve roster | | | Before |
| 7/21/2008 | TEW | Morrow | Promoted to active roster | | | Before |
| 7/21/2008 | TEW | Sampson | Promoted to active roster | | | Before |
| 7/21/2008 | TEW | Wellemeyer | Demoted to reserve roster | | | Before |
| 7/22/2008 | NYD | Capps | Demoted to reserve roster | | | Before |
| 7/22/2008 | NYD | Neshek | Promoted to active roster | | | Before |
| 7/23/2008 | BBG | Casilla,S | Promoted to active roster | | | Before |
| 7/23/2008 | BBG | Hoffman | Demoted to reserve roster | | | Before |
| 7/23/2008 | BBG | Peralta,Jo | Promoted to active roster | | | Before |
| 7/23/2008 | BBG | Perez,Ol | Demoted to reserve roster | | | Before |
| 7/23/2008 | CIN | Byrdak | Promoted to active roster | | | Before |
| 7/23/2008 | CIN | Logan | Demoted to reserve roster | | | Before |
| 7/23/2008 | CTW | Bannister | Placed on disabled list | | 7/23/2008 | Before |
| 7/23/2008 | CTW | Freel | Promoted to active roster | | | Before |
| 7/23/2008 | FDH | Jones,Ad | Demoted to reserve roster | | | Before |
| 7/23/2008 | FDH | Morse | Promoted to active roster | | | Before |
| 7/23/2008 | FDH | Treanor | Demoted to reserve roster | | | Before |
| 7/23/2008 | FDH | Upton,J | Promoted to active roster | | | Before |
| 7/23/2008 | GAR | Cabrera,J | Demoted to reserve roster | | | Before |
| 7/23/2008 | GAR | Grudzielanek | Activated from disabled list | | | Before |
| 7/24/2008 | CIO | Aubrey | Promoted to active roster | | | Before |
| 7/24/2008 | CIO | Roberts,R | Demoted to reserve roster | | | Before |
| 7/24/2008 | GAR | Guardado | Promoted to active roster | | | Before |
| 7/24/2008 | GAR | Hinshaw | Demoted to reserve roster | | | Before |
| 7/24/2008 | GAR | Mock | Demoted to reserve roster | | | Before |
| 7/24/2008 | GAR | Saito | Promoted to active roster | | | Before |
| 7/24/2008 | NYD | Monroe | Demoted to reserve roster | | | Before |
| 7/24/2008 | NYD | Thomas,C | Activated from disabled list | | | Before |
| 7/24/2008 | RYS | O'Flaherty | Demoted to reserve roster | | | Before |
| 7/24/2008 | RYS | Petit,Y | Promoted to active roster | | | Before |
| 7/24/2008 | SOI | Casilla,A | Promoted to active roster | | | Before |
| 7/24/2008 | SOI | Rodriguez,S | Demoted to reserve roster | | | Before |
| 7/25/2008 | AST | Brown,E | Demoted to reserve roster | | | Before |
| 7/25/2008 | AST | Gerut | Promoted to active roster | | | Before |
| 7/25/2008 | BAR | Chamberlain | Activated from disabled list | | | Before |
| 7/25/2008 | BAR | Gonzalez,M | Demoted to reserve roster | | | Before |
| 7/25/2008 | BAR | Dessens | Traded away | RMO | | After |
| 7/25/2008 | BAR | Dotel | Acquired via trade | FDH | | After |
| 7/25/2008 | BAR | Jepsen | Traded away | FDH | | After |
| 7/25/2008 | BAR | Marte,D | Acquired via trade | RMO | | After |
| 7/25/2008 | BBG | Beltre | Activated from disabled list | | | Before |
| 7/25/2008 | BBG | Zobrist | Demoted to reserve roster | | | Before |
| 7/25/2008 | FDH | Dotel | Traded away | BAR | | After |
| 7/25/2008 | FDH | Jepsen | Acquired via trade | BAR | | After |
| 7/25/2008 | RMO | Dessens | Acquired via trade | BAR | | After |
| 7/25/2008 | RMO | Marte,D | Traded away | BAR | | After |
| 7/26/2008 | AST | Jackson,E | Traded away | PHI | | After |
| 7/26/2008 | AST | Mussina | Acquired via trade | PHI | | After |
| 7/26/2008 | BAR | Marte,D | Demoted to reserve roster | | | Before |
| 7/26/2008 | BRK | Drew,S | Traded away | RMO | | After |
| 7/26/2008 | BRK | Perez,R | Acquired via trade | RMO | | After |
| 7/26/2008 | BRK | Ramirez,Ha | Acquired via trade | RMO | | After |
| 7/26/2008 | BRK | Wolf | Traded away | RMO | | After |
| 7/26/2008 | NEP | Campillo | Promoted to active roster | | | Before |
| 7/26/2008 | NEP | Washburn | Demoted to reserve roster | | | Before |
| 7/26/2008 | NYD | Nieves | Demoted to reserve roster | | | Before |
| 7/26/2008 | NYD | Zaun | Activated from disabled list | | | Before |
| 7/26/2008 | PHI | Jackson,E | Acquired via trade | AST | | After |
| 7/26/2008 | PHI | Mussina | Traded away | AST | | After |
| 7/26/2008 | RMO | Dessens | Promoted to active roster | | | Before |
| 7/26/2008 | RMO | Drew,S | Acquired via trade | BRK | | After |
| 7/26/2008 | RMO | Perez,R | Traded away | BRK | | After |
| 7/26/2008 | RMO | Ramirez,Ha | Traded away | BRK | | After |
| 7/26/2008 | RMO | Wolf | Acquired via trade | BRK | | After |
| 7/26/2008 | SOI | Saltalamacchia | Demoted to reserve roster | | | Before |
| 7/26/2008 | SOI | Sandoval,P | Promoted to active roster | | | Before |
| 7/27/2008 | BRK | Perez,R | Demoted to reserve roster | | | Before |
| 7/27/2008 | CIO | Bartlett | Activated from disabled list | | | Before |
| 7/27/2008 | CIO | Blum | Demoted to reserve roster | | | Before |
| 7/27/2008 | NEP | Francisco,F | Demoted to reserve roster | | | Before |
| 7/27/2008 | NEP | Sonnanstine | Promoted to active roster | | | Before |
| 7/27/2008 | PHI | Condrey | Promoted to active roster | | | Before |
| 7/27/2008 | PHI | Cora | Demoted to reserve roster | | | Before |
| 7/27/2008 | PHI | Gross | Demoted to reserve roster | | | Before |
| 7/27/2008 | PHI | Ramirez,RA | Promoted to active roster | | | Before |
| 7/27/2008 | PHI | Ramirez,RS | Promoted to active roster | | | Before |
| 7/27/2008 | PHI | Speier,R | Placed on disabled list | | 7/26/2008 | Before |
| 7/27/2008 | RMO | Brocail | Promoted to active roster | | | Before |
| 7/27/2008 | RMO | Ponson | Placed on disabled list | | 7/27/2008 | Before |
| 7/27/2008 | RMO | Wolf | Promoted to active roster | | | Before |
| 7/27/2008 | TEW | Ransom | Demoted to reserve roster | | | Before |
| 7/27/2008 | TEW | Youkilis | Activated from disabled list | | | Before |
| 7/28/2008 | CIO | Lind | Demoted to reserve roster | | | Before |
| 7/28/2008 | CIO | Raburn | Promoted to active roster | | | Before |
| 7/28/2008 | NEP | Breslow | Demoted to reserve roster | | | Before |
| 7/28/2008 | NEP | Outman | Promoted to active roster | | | Before |
| 7/28/2008 | TEW | Crain | Promoted to active roster | | | Before |
| 7/28/2008 | TEW | Meek | Demoted to reserve roster | | | Before |
| 7/29/2008 | ATM | Holliday | Acquired via trade | GAR | | After |
| 7/29/2008 | ATM | Ludwick | Traded away | GAR | | After |
| 7/29/2008 | ATM | Pelfrey | Acquired via trade | GAR | | After |
| 7/29/2008 | ATM | Santana,E | Traded away | GAR | | After |
| 7/29/2008 | BBG | Oliver | Demoted to reserve roster | | | Before |
| 7/29/2008 | BBG | Thatcher | Promoted to active roster | | | Before |
| 7/29/2008 | GAR | Holliday | Traded away | ATM | | After |
| 7/29/2008 | GAR | Ludwick | Acquired via trade | ATM | | After |
| 7/29/2008 | GAR | Pelfrey | Traded away | ATM | | After |
| 7/29/2008 | GAR | Santana,E | Acquired via trade | ATM | | After |
| 7/30/2008 | ATM | League | Promoted to active roster | | | Before |
| 7/30/2008 | BBG | Betemit | Promoted to active roster | | | Before |
| 7/30/2008 | BBG | Rodney | Demoted to reserve roster | | | Before |
| 7/30/2008 | CBB | Giese | Promoted to active roster | | | Before |
| 7/30/2008 | CBB | Okajima | Demoted to reserve roster | | | Before |
| 7/30/2008 | FDH | Dickey | Demoted to reserve roster | | | Before |
| 7/30/2008 | FDH | Jepsen | Promoted to active roster | | | Before |
| 7/30/2008 | GAR | Lackey | Demoted to reserve roster | | | Before |
| 8/1/2008 | BRK | Baker,Jo | Demoted to reserve roster | | | Before |
| 8/1/2008 | BRK | Baker,Jo | Promoted to active roster | | | Before |
| 8/1/2008 | BRK | Counsell | Promoted to active roster | | | Before |
| 8/1/2008 | BRK | Figgins | Demoted to reserve roster | | | Before |
| 8/1/2008 | BRK | Perez,R | Promoted to active roster | | | Before |
| 8/1/2008 | BRK | Shell | Promoted to active roster | | | Before |
| 8/1/2008 | BRK | Shouse | Demoted to reserve roster | | | Before |
| 8/1/2008 | BRK | Wood,K | Demoted to reserve roster | | | Before |
| 8/1/2008 | CIO | Sherrill | Demoted to reserve roster | | | Before |
| 8/1/2008 | CIO | Sherrill | Promoted to active roster | | | Before |
| 8/1/2008 | NYD | Kuo | Demoted to reserve roster | | | Before |
| 8/2/2008 | BAR | Helton | Demoted to reserve roster | | | Before |
| 8/2/2008 | BAR | Kotchman | Promoted to active roster | | | Before |
| 8/2/2008 | BAR | Marte,D | Promoted to active roster | | | Before |
| 8/2/2008 | BAR | Payton | Promoted to active roster | | | Before |
| 8/2/2008 | BAR | Tallet | Demoted to reserve roster | | | Before |
| 8/2/2008 | BAR | Wigginton | Demoted to reserve roster | | | Before |
| 8/2/2008 | CIN | Chavez,R | Activated from disabled list | | | Before |
| 8/2/2008 | CIN | Willingham | Demoted to reserve roster | | | Before |
| 8/2/2008 | CIO | Blum | Promoted to active roster | | | Before |
| 8/2/2008 | CIO | Drew,J | Demoted to reserve roster | | | Before |
| 8/2/2008 | CIO | Inge | Promoted to active roster | | | Before |
| 8/2/2008 | CIO | Pagan | Demoted to reserve roster | | | Before |
| 8/2/2008 | RMO | Dessens | Demoted to reserve roster | | | Before |
| 8/2/2008 | RMO | Waechter | Promoted to active roster | | | Before |
| 8/3/2008 | NYD | Thomas,C | Demoted to reserve roster | | | Before |
| 8/4/2008 | BRK | Coke | Demoted to reserve roster | | | Before |
| 8/4/2008 | CIN | Byrdak | Demoted to reserve roster | | | Before |
| 8/4/2008 | CIN | Guerrier | Promoted to active roster | | | Before |
| 8/4/2008 | CIN | Miller,T | Promoted to active roster | | | Before |
| 8/4/2008 | CIN | Perez,C | Demoted to reserve roster | | | Before |
| 8/4/2008 | CIN | Villanueva | Demoted to reserve roster | | | Before |
| 8/4/2008 | CIN | Walker,T | Promoted to active roster | | | Before |
| 8/4/2008 | NYD | Cormier | Promoted to active roster | | | Before |
| 8/4/2008 | NYD | Monroe | Promoted to active roster | | | Before |
| 8/5/2008 | BBG | Montero | Promoted to active roster | | | Before |
| 8/5/2008 | BBG | Schneider | Placed on disabled list | | 8/5/2008 | Before |
| 8/5/2008 | BRK | Balfour | Promoted to active roster | | | Before |
| 8/5/2008 | BRK | Edmonds | Placed on disabled list | | 8/4/2008 | Before |
| 8/5/2008 | BRK | Gwynn | Promoted to active roster | | | Before |
| 8/5/2008 | CTW | Nippert | Promoted to active roster | | | Before |
| 8/5/2008 | CTW | Olivo | Activated from disabled list | | | Before |
| 8/5/2008 | CTW | Rolen | Demoted to reserve roster | | | Before |
| 8/5/2008 | CTW | Smith,Jo | Demoted to reserve roster | | | Before |
| 8/5/2008 | FDH | Pena,TF | Placed on disabled list | | 8/3/2008 | Before |
| 8/5/2008 | FDH | Quiroz | Promoted to active roster | | | Before |
| 8/5/2008 | HAR | Hochevar | Promoted to active roster | | | Before |
| 8/5/2008 | HAR | Pearce | Demoted to reserve roster | | | Before |
| 8/5/2008 | PHI | Arroyo | Promoted to active roster | | | Before |
| 8/5/2008 | PHI | Condrey | Demoted to reserve roster | | | Before |
| 8/5/2008 | PHI | Cora | Promoted to active roster | | | Before |
| 8/5/2008 | PHI | Gross | Promoted to active roster | | | Before |
| 8/5/2008 | PHI | Myers | Placed on disabled list | | 7/31/2008 | Before |
| 8/5/2008 | PHI | Victorino | Placed on disabled list | | 7/30/2008 | Before |
| 8/6/2008 | NEP | Bush | Demoted to reserve roster | | | Before |
| 8/6/2008 | NEP | Washburn | Promoted to active roster | | | Before |
| 8/6/2008 | RYS | LaRoche,An | Demoted to reserve roster | | | Before |
| 8/6/2008 | RYS | Ross,C | Activated from disabled list | | | Before |
| 8/7/2008 | AST | Springer | Demoted to reserve roster | | | Before |
| 8/7/2008 | AST | Ziegler | Promoted to active roster | | | Before |
| 8/7/2008 | ATM | Motte | Promoted to active roster | | | Before |
| 8/7/2008 | ATM | Papelbon | Demoted to reserve roster | | | Before |
| 8/7/2008 | CIN | Choo | Demoted to reserve roster | | | Before |
| 8/7/2008 | CIN | Miller,Ju | Promoted to active roster | | | Before |
| 8/7/2008 | SOI | Sandoval,P | Demoted to reserve roster | | | Before |
| 8/7/2008 | SOI | Sardinha | Promoted to active roster | | | Before |
| 8/7/2008 | TEW | Johnson,Ji | Promoted to active roster | | | Before |
| 8/7/2008 | TEW | Wade | Demoted to reserve roster | | | Before |
| 8/8/2008 | CTW | Bannister | Activated from disabled list | | | Before |
| 8/8/2008 | CTW | Vizquel | Demoted to reserve roster | | | Before |
| 8/8/2008 | FDH | Denorfia | Promoted to active roster | | | Before |
| 8/8/2008 | FDH | Hardy | Demoted to reserve roster | | | Before |
| 8/8/2008 | FDH | Kendrick,H | Promoted to active roster | | | Before |
| 8/8/2008 | FDH | Lohse | Demoted to reserve roster | | | Before |
| 8/8/2008 | FDH | Morton,Ch | Promoted to active roster | | | Before |
| 8/8/2008 | FDH | Peralta,Jh | Demoted to reserve roster | | | Before |
| 8/8/2008 | SOI | Hudson,T | Placed on disabled list | | 8/8/2008 | Before |
| 8/8/2008 | SOI | Redding | Promoted to active roster | | | Before |
| 8/9/2008 | BRK | Gregg | Promoted to active roster | | | Before |
| 8/9/2008 | BRK | Hinckley | Demoted to reserve roster | | | Before |
| 8/9/2008 | BRK | Sanches,B | Demoted to reserve roster | | | Before |
| 8/9/2008 | BRK | Stetter | Promoted to active roster | | | Before |
| 8/9/2008 | RYS | Crede | Promoted to active roster | | | Before |
| 8/9/2008 | RYS | Davis,R | Demoted to reserve roster | | | Before |
| 8/9/2008 | RYS | Guzman,C | Promoted to active roster | | | Before |
| 8/9/2008 | RYS | Hundley | Promoted to active roster | | | Before |
| 8/9/2008 | RYS | Laird | Promoted to active roster | | | Before |
| 8/9/2008 | RYS | Lopez,Ja | Demoted to reserve roster | | | Before |
| 8/9/2008 | RYS | Manning | Promoted to active roster | | | Before |
| 8/9/2008 | RYS | Molina,J | Demoted to reserve roster | | | Before |
| 8/9/2008 | RYS | Pineiro | Placed on disabled list | | 8/9/2008 | Before |
| 8/9/2008 | RYS | Quintero | Demoted to reserve roster | | | Before |
| 8/9/2008 | RYS | Veras | Demoted to reserve roster | | | Before |
| 8/9/2008 | RYS | Weeks | Promoted to active roster | | | Before |
| 8/10/2008 | CIO | Howell | Promoted to active roster | | | Before |
| 8/10/2008 | CIO | Thornton | Demoted to reserve roster | | | Before |
| 8/10/2008 | HAR | Niese | Demoted to reserve roster | | | Before |
| 8/10/2008 | SOI | Hill,R | Demoted to reserve roster | | | Before |
| 8/10/2008 | SOI | McDonald,Ja | Promoted to active roster | | | Before |
| 8/11/2008 | BAR | Anderson,J | Demoted to reserve roster | | | Before |
| 8/11/2008 | BAR | Erstad | Promoted to active roster | | | Before |
| 8/11/2008 | BBG | Feldman | Demoted to reserve roster | | | Before |
| 8/11/2008 | BBG | Perez,Ol | Promoted to active roster | | | Before |
| 8/11/2008 | CBB | Lincoln | Demoted to reserve roster | | | Before |
| 8/11/2008 | CEN | Billingsley | Demoted to reserve roster | | | Before |
| 8/11/2008 | CEN | Corpas | Demoted to reserve roster | | | Before |
| 8/11/2008 | CEN | Oswalt | Activated from disabled list | | | Before |
| 8/11/2008 | CEN | Zambrano | Activated from disabled list | | | Before |
| 8/11/2008 | NEP | Outman | Demoted to reserve roster | | | Before |
| 8/11/2008 | NYD | Neshek | Demoted to reserve roster | | | Before |
| 8/11/2008 | NYD | Sarfate | Promoted to active roster | | | Before |
| 8/11/2008 | RMO | Lee,Ca | Demoted to reserve roster | | | Before |
| 8/12/2008 | BRK | Baker,Jo | Promoted to active roster | | | Before |
| 8/12/2008 | BRK | Wainwright | Demoted to reserve roster | | | Before |
| 8/12/2008 | CEN | Billingsley | Promoted to active roster | | | Before |
| 8/12/2008 | CEN | Bradford | Demoted to reserve roster | | | Before |
| 8/12/2008 | HAR | Liriano | Activated from disabled list | | | Before |
| 8/12/2008 | NEP | Belliard | Demoted to reserve roster | | | Before |
| 8/12/2008 | NEP | Dickerson | Promoted to active roster | | | Before |
| 8/12/2008 | NEP | Francisco,F | Promoted to active roster | | | Before |
| 8/12/2008 | NEP | Iannetta | Demoted to reserve roster | | | Before |
| 8/12/2008 | NEP | Salazar,O | Promoted to active roster | | | Before |
| 8/12/2008 | NEP | Shealy | Demoted to reserve roster | | | Before |
| 8/12/2008 | NEP | Teagarden | Promoted to active roster | | | Before |
| 8/12/2008 | NYD | Ledezma | Demoted to reserve roster | | | Before |
| 8/12/2008 | NYD | Nieves | Promoted to active roster | | | Before |
| 8/12/2008 | SOI | Marson | Promoted to active roster | | | Before |
| 8/12/2008 | SOI | Sardinha | Demoted to reserve roster | | | Before |
| 8/13/2008 | CIO | Masset | Promoted to active roster | | | Before |
| 8/13/2008 | CIO | Sherrill | Demoted to reserve roster | | | Before |
| 8/13/2008 | FDH | Cruz,L | Demoted to reserve roster | | | Before |
| 8/13/2008 | NEP | Cantu | Promoted to active roster | | | Before |
| 8/13/2008 | NEP | Salazar,O | Demoted to reserve roster | | | Before |
| 8/13/2008 | TEW | Johnson,Ji | Demoted to reserve roster | | | Before |
| 8/13/2008 | TEW | Maine | Demoted to reserve roster | | | Before |
| 8/13/2008 | TEW | Wellemeyer | Promoted to active roster | | | Before |
| 8/13/2008 | TEW | Wolfe | Promoted to active roster | | | Before |
| 8/14/2008 | AST | Brown,E | Promoted to active roster | | | Before |
| 8/14/2008 | AST | Thome | Demoted to reserve roster | | | Before |
| 8/14/2008 | CEN | Morales,K | Demoted to reserve roster | | | Before |
| 8/14/2008 | CEN | Redmond | Promoted to active roster | | | Before |
| 8/14/2008 | CIN | Cordero,F | Demoted to reserve roster | | | Before |
| 8/14/2008 | CIN | Villanueva | Promoted to active roster | | | Before |
| 8/14/2008 | RMO | Ankiel | Demoted to reserve roster | | | Before |
| 8/14/2008 | RMO | Kotsay | Promoted to active roster | | | Before |
| 8/14/2008 | RMO | Murphy,Do | Promoted to active roster | | | Before |
| 8/14/2008 | SOI | Castro,R | Demoted to reserve roster | | | Before |
| 8/14/2008 | SOI | Marson | Demoted to reserve roster | | | Before |
| 8/14/2008 | SOI | Stewart,C | Promoted to active roster | | | Before |
| 8/14/2008 | SOI | Valentin | Promoted to active roster | | | Before |
| 8/15/2008 | ATM | Camp | Demoted to reserve roster | | | Before |
| 8/15/2008 | ATM | Camp | Promoted to active roster | | | Before |
| 8/15/2008 | ATM | Nunez,L | Promoted to active roster | | | Before |
| 8/15/2008 | ATM | Robertson,D | Demoted to reserve roster | | | Before |
| 8/15/2008 | BBG | Parra | Promoted to active roster | | | Before |
| 8/15/2008 | BBG | Weaver | Demoted to reserve roster | | | Before |
| 8/15/2008 | BRK | Baker,Jo | Demoted to reserve roster | | | Before |
| 8/15/2008 | BRK | Wainwright | Promoted to active roster | | | Before |
| 8/15/2008 | NYD | Moyer | Promoted to active roster | | | Before |
| 8/15/2008 | NYD | Nieves | Demoted to reserve roster | | | Before |
| 8/15/2008 | NYD | Nieves | Promoted to active roster | | | Before |
| 8/15/2008 | NYD | Ryan,D | Demoted to reserve roster | | | Before |
| 8/17/2008 | BBG | Feldman | Promoted to active roster | | | Before |
| 8/17/2008 | BBG | Madson | Demoted to reserve roster | | | Before |
| 8/17/2008 | CIN | Amezaga | Promoted to active roster | | | Before |
| 8/17/2008 | CIN | Farnsworth | Demoted to reserve roster | | | Before |
| 8/17/2008 | CIN | Perez,C | Promoted to active roster | | | Before |
| 8/17/2008 | CIN | Ramirez,Al | Demoted to reserve roster | | | Before |
| 8/17/2008 | CIO | Gutierrez | Demoted to reserve roster | | | Before |
| 8/17/2008 | CIO | Marte,A | Promoted to active roster | | | Before |
| 8/17/2008 | FDH | Belisle | Promoted to active roster | | | Before |
| 8/17/2008 | FDH | Cruz,N | Demoted to reserve roster | | | Before |
| 8/17/2008 | FDH | Hardy | Promoted to active roster | | | Before |
| 8/17/2008 | FDH | Kendrick,H | Placed on disabled list | | 8/14/2008 | Before |
| 8/17/2008 | FDH | Morse | Demoted to reserve roster | | | Before |
| 8/17/2008 | FDH | Peralta,Jh | Promoted to active roster | | | Before |
| 8/17/2008 | PHI | Lindstrom | Demoted to reserve roster | | | Before |
| 8/18/2008 | CIN | Cabrera,A | Demoted to reserve roster | | | Before |
| 8/18/2008 | CIN | Easley | Promoted to active roster | | | Before |
| 8/19/2008 | AST | Slowey | Placed on disabled list | | 8/16/2008 | Before |
| 8/19/2008 | AST | Young,CR | Promoted to active roster | | | Before |
| 8/20/2008 | AST | Fontenot | Demoted to reserve roster | | | Before |
| 8/20/2008 | AST | LaRoche,Ad | Promoted to active roster | | | Before |
| 8/20/2008 | AST | Lugo | Promoted to active roster | | | Before |
| 8/20/2008 | AST | Murphy,Dan | Demoted to reserve roster | | | Before |
| 8/20/2008 | ATM | Street | Demoted to reserve roster | | | Before |
| 8/20/2008 | ATM | Westbrook | Promoted to active roster | | | Before |
| 8/20/2008 | CBB | Acosta | Demoted to reserve roster | | | Before |
| 8/20/2008 | CBB | Boyer | Promoted to active roster | | | Before |
| 8/20/2008 | CBB | Embree | Promoted to active roster | | | Before |
| 8/20/2008 | CBB | Kobayashi | Promoted to active roster | | | Before |
| 8/20/2008 | CBB | Linebrink | Demoted to reserve roster | | | Before |
| 8/20/2008 | GAR | Cruz,Ju | Promoted to active roster | | | Before |
| 8/20/2008 | GAR | Saito | Demoted to reserve roster | | | Before |
| 8/20/2008 | PHI | Hawkins | Demoted to reserve roster | | | Before |
| 8/20/2008 | PHI | Speier,R | Activated from disabled list | | | Before |
| 8/20/2008 | PHI | Victorino | Activated from disabled list | | | Before |
| 8/20/2008 | TEW | Adams | Demoted to reserve roster | | | Before |
| 8/20/2008 | TEW | Birkins | Promoted to active roster | | | Before |
| 8/20/2008 | TEW | Gonzalez,C | Demoted to reserve roster | | | Before |
| 8/20/2008 | TEW | Loretta | Promoted to active roster | | | Before |
| 8/21/2008 | AST | Beimel | Promoted to active roster | | | Before |
| 8/21/2008 | AST | Fuentes | Demoted to reserve roster | | | Before |
| 8/21/2008 | FDH | Pena,TF | Activated from disabled list | | | Before |
| 8/21/2008 | GAR | Lackey | Promoted to active roster | | | Before |
| 8/21/2008 | GAR | Wakefield | Demoted to reserve roster | | | Before |
| 8/21/2008 | SOI | McDonald,Ja | Demoted to reserve roster | | | Before |
| 8/22/2008 | CIN | Frandsen | Promoted to active roster | | | Before |
| 8/22/2008 | CIN | Guerrier | Demoted to reserve roster | | | Before |
| 8/22/2008 | GAR | Johnson,Ra | Demoted to reserve roster | | | Before |
| 8/22/2008 | GAR | Reyes,An | Promoted to active roster | | | Before |
| 8/22/2008 | SOI | Pauley | Promoted to active roster | | | Before |
| 8/23/2008 | CEN | Isringhausen | Promoted to active roster | | | Before |
| 8/23/2008 | CEN | Nathan | Demoted to reserve roster | | | Before |
| 8/23/2008 | CEN | Soria | Demoted to reserve roster | | | Before |
| 8/23/2008 | CEN | Weathers | Promoted to active roster | | | Before |
| 8/23/2008 | CIO | Hill,A | Promoted to active roster | | | Before |
| 8/23/2008 | CIO | Ojeda | Demoted to reserve roster | | | Before |
| 8/23/2008 | FDH | Hamels | Demoted to reserve roster | | | Before |
| 8/24/2008 | ATM | Delcarmen | Promoted to active roster | | | Before |
| 8/24/2008 | ATM | League | Demoted to reserve roster | | | Before |
| 8/24/2008 | BBG | Montero | Demoted to reserve roster | | | Before |
| 8/24/2008 | BBG | Schneider | Activated from disabled list | | | Before |
| 8/25/2008 | AST | LaRoche,Ad | Demoted to reserve roster | | | Before |
| 8/25/2008 | AST | Murphy,Dan | Promoted to active roster | | | Before |
| 8/25/2008 | CIN | Fowler | Promoted to active roster | | | Before |
| 8/25/2008 | CIN | Villanueva | Demoted to reserve roster | | | Before |
| 8/25/2008 | CIO | Marquis | Demoted to reserve roster | | | Before |
| 8/25/2008 | CIO | Padilla | Promoted to active roster | | | Before |
| 8/25/2008 | SOI | Fogg | Promoted to active roster | | | Before |
| 8/25/2008 | SOI | Pauley | Demoted to reserve roster | | | Before |
| 8/25/2008 | SOI | Sardinha | Promoted to active roster | | | Before |
| 8/25/2008 | SOI | Stewart,C | Demoted to reserve roster | | | Before |
| 8/26/2008 | BAR | Duchscherer | Demoted to reserve roster | | | Before |
| 8/26/2008 | BAR | Vargas | Promoted to active roster | | | Before |
| 8/26/2008 | BAR | Wells,V | Demoted to reserve roster | | | Before |
| 8/26/2008 | BAR | Wise,D | Promoted to active roster | | | Before |
| 8/26/2008 | CIO | Masset | Demoted to reserve roster | | | Before |
| 8/26/2008 | CIO | Moylan | Promoted to active roster | | | Before |
| 8/26/2008 | FDH | Bailey,H | Promoted to active roster | | | Before |
| 8/26/2008 | FDH | Belisle | Demoted to reserve roster | | | Before |
| 8/26/2008 | FDH | Cotts | Promoted to active roster | | | Before |
| 8/28/2008 | ATM | Motte | Placed on disabled list | | 8/27/2008 | Before |
| 8/28/2008 | ATM | Papelbon | Promoted to active roster | | | Before |
| 8/28/2008 | BBG | Casilla,S | Placed on disabled list | | 8/26/2008 | Before |
| 8/28/2008 | BBG | Weaver | Promoted to active roster | | | Before |
| 8/28/2008 | CIN | Perez,C | Demoted to reserve roster | | | Before |
| 8/28/2008 | CIN | Ramirez,Al | Promoted to active roster | | | Before |
| 8/28/2008 | CIO | Eyre | Demoted to reserve roster | | | Before |
| 8/28/2008 | CIO | Hoover | Promoted to active roster | | | Before |
| 8/28/2008 | GAR | Reyes,An | Demoted to reserve roster | | | Before |
| 8/28/2008 | GAR | Wakefield | Promoted to active roster | | | Before |
| 8/28/2008 | PHI | Ramirez,RA | Demoted to reserve roster | | | Before |
| 8/29/2008 | AST | Litsch | Promoted to active roster | | | Before |
| 8/29/2008 | AST | Maholm | Placed on disabled list | | 8/29/2008 | Before |
| 8/29/2008 | CBB | Kershaw | Demoted to reserve roster | | | Before |
| 8/29/2008 | CIO | Ryan,Br | Demoted to reserve roster | | | Before |
| 8/29/2008 | CIO | Tejeda,R | Promoted to active roster | | | Before |
| 8/29/2008 | GAR | Johnson,Ra | Promoted to active roster | | | Before |
| 8/29/2008 | GAR | Park | Demoted to reserve roster | | | Before |
| 8/29/2008 | PHI | Bako | Promoted to active roster | | | Before |
| 8/29/2008 | PHI | Ruiz,C | Demoted to reserve roster | | | Before |
| 8/30/2008 | NYD | Broxton | Demoted to reserve roster | | | Before |
| 8/30/2008 | NYD | Hughes | Promoted to active roster | | | Before |
| 8/30/2008 | PHI | Condrey | Promoted to active roster | | | Before |
| 8/30/2008 | PHI | Dolsi | Promoted to active roster | | | Before |
| 8/30/2008 | PHI | Qualls | Demoted to reserve roster | | | Before |
| 8/30/2008 | PHI | Romero,J | Demoted to reserve roster | | | Before |
| 8/30/2008 | PHI | Yabu | Promoted to active roster | | | Before |
| 8/31/2008 | CIO | Drew,J | Promoted to active roster | | | Before |
| 8/31/2008 | CIO | Raburn | Demoted to reserve roster | | | Before |
| 9/1/2008 | AST | Brown,A | Promoted to active roster | | | Before |
| 9/1/2008 | AST | Cash | Promoted to active roster | | | Before |
| 9/1/2008 | AST | Dumatrait | Promoted to active roster | | | Before |
| 9/1/2008 | AST | Fontenot | Promoted to active roster | | | Before |
| 9/1/2008 | AST | Hernandez,A | Promoted to active roster | | | Before |
| 9/1/2008 | AST | Holm | Promoted to active roster | | | Before |
| 9/1/2008 | AST | Jacobs | Promoted to active roster | | | Before |
| 9/1/2008 | AST | Johnson,Re | Promoted to active roster | | | Before |
| 9/1/2008 | AST | Langerhans | Promoted to active roster | | | Before |
| 9/1/2008 | AST | Litsch | Demoted to reserve roster | | | Before |
| 9/1/2008 | AST | Mota | Promoted to active roster | | | Before |
| 9/1/2008 | AST | Schoeneweis | Promoted to active roster | | | Before |
| 9/1/2008 | AST | Slowey | Activated from disabled list | | | Before |
| 9/1/2008 | AST | Springer | Promoted to active roster | | | Before |
| 9/1/2008 | AST | Teahen | Promoted to active roster | | | Before |
| 9/1/2008 | AST | Thome | Promoted to active roster | | | Before |
| 9/1/2008 | AST | Yates | Promoted to active roster | | | Before |
| 9/1/2008 | BAR | Smoltz | Demoted to reserve roster | | | Before |
| 9/1/2008 | BRK | Baker,Jo | Promoted to active roster | | | Before |
| 9/1/2008 | BRK | Corcoran | Promoted to active roster | | | Before |
| 9/1/2008 | BRK | Edmonds | Activated from disabled list | | | Before |
| 9/1/2008 | BRK | Figgins | Promoted to active roster | | | Before |
| 9/1/2008 | BRK | Gathright | Promoted to active roster | | | Before |
| 9/1/2008 | BRK | Matsui,K | Promoted to active roster | | | Before |
| 9/1/2008 | BRK | McCarthy | Promoted to active roster | | | Before |
| 9/1/2008 | BRK | Rivera,J | Promoted to active roster | | | Before |
| 9/1/2008 | BRK | Sanchez,D | Promoted to active roster | | | Before |
| 9/1/2008 | BRK | Shouse | Promoted to active roster | | | Before |
| 9/1/2008 | BRK | Torres,S | Promoted to active roster | | | Before |
| 9/1/2008 | BRK | Wagner | Promoted to active roster | | | Before |
| 9/1/2008 | BRK | Wood,K | Promoted to active roster | | | Before |
| 9/1/2008 | CEN | Barrett | Promoted to active roster | | | Before |
| 9/1/2008 | CEN | Berroa | Promoted to active roster | | | Before |
| 9/1/2008 | CEN | Cancel | Promoted to active roster | | | Before |
| 9/1/2008 | CEN | Corpas | Promoted to active roster | | | Before |
| 9/1/2008 | CEN | Morales,K | Promoted to active roster | | | Before |
| 9/1/2008 | CEN | Reyes,D | Promoted to active roster | | | Before |
| 9/1/2008 | CEN | Snider | Promoted to active roster | | | Before |
| 9/1/2008 | CIN | Cabrera,A | Promoted to active roster | | | Before |
| 9/1/2008 | CIN | Choo | Promoted to active roster | | | Before |
| 9/1/2008 | CIN | Hawpe | Promoted to active roster | | | Before |
| 9/1/2008 | CIN | Willingham | Promoted to active roster | | | Before |
| 9/1/2008 | CIN | Young,Delm | Promoted to active roster | | | Before |
| 9/1/2008 | CTW | Badenhop | Promoted to active roster | | | Before |
| 9/1/2008 | CTW | LeBlanc | Promoted to active roster | | | Before |
| 9/1/2008 | CTW | Verlander | Demoted to reserve roster | | | Before |
| 9/1/2008 | FDH | Jepsen | Demoted to reserve roster | | | Before |
| 9/1/2008 | GAR | Alou | Promoted to active roster | | | Before |
| 9/1/2008 | GAR | Cabrera,J | Promoted to active roster | | | Before |
| 9/1/2008 | GAR | Clark,T | Promoted to active roster | | | Before |
| 9/1/2008 | GAR | Hinshaw | Promoted to active roster | | | Before |
| 9/1/2008 | GAR | McClung | Promoted to active roster | | | Before |
| 9/1/2008 | GAR | Mock | Promoted to active roster | | | Before |
| 9/1/2008 | GAR | Pie | Promoted to active roster | | | Before |
| 9/1/2008 | GAR | Ryan,BJ | Promoted to active roster | | | Before |
| 9/1/2008 | GAR | Stairs | Promoted to active roster | | | Before |
| 9/1/2008 | GAR | Thomas,F | Promoted to active roster | | | Before |
| 9/1/2008 | HAR | Liriano | Demoted to reserve roster | | | Before |
| 9/1/2008 | NEP | Wheeler | Demoted to reserve roster | | | Before |
| 9/1/2008 | NYD | Everett | Promoted to active roster | | | Before |
| 9/1/2008 | NYD | Hammock | Promoted to active roster | | | Before |
| 9/1/2008 | NYD | Melhuse | Promoted to active roster | | | Before |
| 9/1/2008 | NYD | Sammons | Promoted to active roster | | | Before |
| 9/1/2008 | NYD | Seay | Promoted to active roster | | | Before |
| 9/1/2008 | NYD | Zaun | Demoted to reserve roster | | | Before |
| 9/1/2008 | SOI | Aybar,W | Promoted to active roster | | | Before |
| 9/1/2008 | SOI | Bonifacio | Promoted to active roster | | | Before |
| 9/1/2008 | SOI | Castro,R | Promoted to active roster | | | Before |
| 9/1/2008 | SOI | Escobar,A | Promoted to active roster | | | Before |
| 9/1/2008 | SOI | Getz | Promoted to active roster | | | Before |
| 9/1/2008 | SOI | Gonzalez,Al | Promoted to active roster | | | Before |
| 9/1/2008 | SOI | Mendoza | Promoted to active roster | | | Before |
| 9/1/2008 | SOI | Rodriguez,S | Promoted to active roster | | | Before |
| 9/1/2008 | SOI | Saltalamacchia | Promoted to active roster | | | Before |
| 9/1/2008 | TEW | Abercrombie | Promoted to active roster | | | Before |
| 9/1/2008 | TEW | Adams | Promoted to active roster | | | Before |
| 9/1/2008 | TEW | Buchholz,T | Promoted to active roster | | | Before |
| 9/1/2008 | TEW | DiFelice,Ma | Promoted to active roster | | | Before |
| 9/1/2008 | TEW | Hensley | Promoted to active roster | | | Before |
| 9/1/2008 | TEW | Inglett | Promoted to active roster | | | Before |
| 9/1/2008 | TEW | Loux | Promoted to active roster | | | Before |
| 9/1/2008 | TEW | Perez,F | Promoted to active roster | | | Before |
| 9/1/2008 | TEW | Sanchez,G | Promoted to active roster | | | Before |
| 9/1/2008 | TEW | Santos | Promoted to active roster | | | Before |
| 9/2/2008 | BBG | Diaz,M | Promoted to active roster | | | Before |
| 9/2/2008 | BBG | Hanigan | Promoted to active roster | | | Before |
| 9/2/2008 | BBG | Ruggiano | Promoted to active roster | | | Before |
| 9/2/2008 | BBG | Ruiz,R | Promoted to active roster | | | Before |
| 9/2/2008 | BBG | Zobrist | Promoted to active roster | | | Before |
| 9/2/2008 | BRK | McCarthy | Demoted to reserve roster | | | Before |
| 9/2/2008 | NEP | Benoit | Promoted to active roster | | | Before |
| 9/2/2008 | NEP | Bush | Promoted to active roster | | | Before |
| 9/2/2008 | NEP | Jaso | Promoted to active roster | | | Before |
| 9/2/2008 | NEP | Nix,L | Promoted to active roster | | | Before |
| 9/2/2008 | NEP | Washburn | Demoted to reserve roster | | | Before |
| 9/2/2008 | NEP | Wuertz | Promoted to active roster | | | Before |
| 9/2/2008 | SOI | Francis | Demoted to reserve roster | | | Before |
| 9/3/2008 | CEN | Jones,C | Demoted to reserve roster | | | Before |
| 9/3/2008 | CTW | Rolen | Promoted to active roster | | | Before |
| 9/3/2008 | CTW | Vizquel | Promoted to active roster | | | Before |
| 9/3/2008 | GAR | Lewis,S | Promoted to active roster | | | Before |
| 9/3/2008 | HAR | Ardoin | Promoted to active roster | | | Before |
| 9/3/2008 | HAR | Boggs,B | Promoted to active roster | | | Before |
| 9/3/2008 | HAR | Boggs,M | Promoted to active roster | | | Before |
| 9/3/2008 | HAR | Burton | Promoted to active roster | | | Before |
| 9/3/2008 | HAR | Feliciano | Promoted to active roster | | | Before |
| 9/3/2008 | HAR | Johnson,Ro | Promoted to active roster | | | Before |
| 9/3/2008 | HAR | Pearce | Promoted to active roster | | | Before |
| 9/3/2008 | HAR | Reed | Promoted to active roster | | | Before |
| 9/3/2008 | HAR | Velez | Activated from disabled list | | | Before |
| 9/3/2008 | PHI | Myers | Activated from disabled list | | | Before |
| 9/3/2008 | RMO | Bennett,G | Promoted to active roster | | | Before |
| 9/3/2008 | RMO | Chulk | Promoted to active roster | | | Before |
| 9/3/2008 | RMO | Colome | Demoted to reserve roster | | | Before |
| 9/3/2008 | RMO | Iguchi | Promoted to active roster | | | Before |
| 9/3/2008 | RMO | Millar | Promoted to active roster | | | Before |
| 9/3/2008 | RMO | Montz | Promoted to active roster | | | Before |
| 9/3/2008 | RMO | Ponson | Activated from disabled list | | | Before |
| 9/3/2008 | RMO | Stokes | Promoted to active roster | | | Before |
| 9/4/2008 | BAR | Anderson,J | Promoted to active roster | | | Before |
| 9/4/2008 | BAR | Dotel | Promoted to active roster | | | Before |
| 9/4/2008 | BAR | Haeger | Promoted to active roster | | | Before |
| 9/4/2008 | BAR | Helton | Promoted to active roster | | | Before |
| 9/4/2008 | BAR | Iwamura | Promoted to active roster | | | Before |
| 9/4/2008 | BAR | Ordonez | Promoted to active roster | | | Before |
| 9/4/2008 | BAR | Percival | Promoted to active roster | | | Before |
| 9/4/2008 | BAR | Rodriguez,L | Promoted to active roster | | | Before |
| 9/4/2008 | BAR | Stockman | Promoted to active roster | | | Before |
| 9/4/2008 | BAR | Wigginton | Promoted to active roster | | | Before |
| 9/4/2008 | CTW | LeBlanc | Demoted to reserve roster | | | Before |
| 9/4/2008 | FDH | Bailey,H | Demoted to reserve roster | | | Before |
| 9/4/2008 | FDH | Chavez,J | Promoted to active roster | | | Before |
| 9/4/2008 | FDH | Cotts | Demoted to reserve roster | | | Before |
| 9/4/2008 | FDH | Cruz,N | Promoted to active roster | | | Before |
| 9/4/2008 | FDH | Denorfia | Demoted to reserve roster | | | Before |
| 9/4/2008 | FDH | Dickey | Promoted to active roster | | | Before |
| 9/4/2008 | FDH | Gordon,A | Activated from disabled list | | | Before |
| 9/4/2008 | NYD | Bell | Demoted to reserve roster | | | Before |
| 9/4/2008 | PHI | Anderson,B | Promoted to active roster | | | Before |
| 9/4/2008 | PHI | Bonderman | Promoted to active roster | | | Before |
| 9/4/2008 | PHI | Floyd,C | Promoted to active roster | | | Before |
| 9/4/2008 | PHI | Francisco,B | Promoted to active roster | | | Before |
| 9/4/2008 | PHI | Ishikawa | Promoted to active roster | | | Before |
| 9/4/2008 | PHI | Perez,Od | Promoted to active roster | | | Before |
| 9/4/2008 | PHI | Quintanilla | Promoted to active roster | | | Before |
| 9/4/2008 | PHI | Riggans | Promoted to active roster | | | Before |
| 9/4/2008 | PHI | Thigpen | Promoted to active roster | | | Before |
| 9/4/2008 | RMO | Rodriguez,F | Demoted to reserve roster | | | Before |
| 9/4/2008 | RYS | Hafner | Promoted to active roster | | | Before |
| 9/4/2008 | RYS | LaRoche,An | Promoted to active roster | | | Before |
| 9/4/2008 | RYS | Mijares | Promoted to active roster | | | Before |
| 9/4/2008 | RYS | Wells,R | Promoted to active roster | | | Before |
| 9/4/2008 | SOI | Beckett | Demoted to reserve roster | | | Before |
| 9/5/2008 | AST | Fontenot | Demoted to reserve roster | | | Before |
| 9/5/2008 | CIN | Frandsen | Demoted to reserve roster | | | Before |
| 9/5/2008 | CIO | Aardsma | Demoted to reserve roster | | | Before |
| 9/5/2008 | CIO | Carpenter,C | Promoted to active roster | | | Before |
| 9/5/2008 | CIO | Marquis | Promoted to active roster | | | Before |
| 9/5/2008 | GAR | Ridgway | Promoted to active roster | | | Before |
| 9/5/2008 | SOI | Johnson,E | Demoted to reserve roster | | | Before |
| 9/5/2008 | TEW | Adams | Demoted to reserve roster | | | Before |
| 9/5/2008 | TEW | Buchholz,T | Demoted to reserve roster | | | Before |
| 9/5/2008 | TEW | Santos | Demoted to reserve roster | | | Before |
| 9/6/2008 | CEN | Bray | Demoted to reserve roster | | | Before |
| 9/6/2008 | NEP | Jaso | Demoted to reserve roster | | | Before |
| 9/6/2008 | PHI | Arroyo | Demoted to reserve roster | | | Before |
| 9/6/2008 | SOI | Getz | Demoted to reserve roster | | | Before |
| 9/7/2008 | BAR | Cameron,K | Promoted to active roster | | | Before |
| 9/7/2008 | BAR | Renteria | Demoted to reserve roster | | | Before |
| 9/7/2008 | BAR | Span | Demoted to reserve roster | | | Before |
| 9/7/2008 | BAR | Tallet | Promoted to active roster | | | Before |
| 9/7/2008 | CIN | Chavez,R | Demoted to reserve roster | | | Before |
| 9/7/2008 | PHI | Baker,S | Demoted to reserve roster | | | Before |
| 9/7/2008 | RYS | Sanchez,J | Demoted to reserve roster | | | Before |
| 9/7/2008 | SOI | Castro,R | Demoted to reserve roster | | | Before |
| 9/7/2008 | TEW | Birkins | Demoted to reserve roster | | | Before |
| 9/9/2008 | BAR | Schierholtz | Demoted to reserve roster | | | Before |
| 9/9/2008 | CIN | Cordero,F | Promoted to active roster | | | Before |
| 9/9/2008 | CIN | Rauch | Demoted to reserve roster | | | Before |
| 9/9/2008 | CTW | Blevins | Promoted to active roster | | | Before |
| 9/9/2008 | CTW | Callaspo | Promoted to active roster | | | Before |
| 9/9/2008 | CTW | Estrada,J | Promoted to active roster | | | Before |
| 9/9/2008 | CTW | Garcia,F | Promoted to active roster | | | Before |
| 9/9/2008 | CTW | Garcia,J | Promoted to active roster | | | Before |
| 9/9/2008 | CTW | Gomes,J | Promoted to active roster | | | Before |
| 9/9/2008 | CTW | Joyce | Promoted to active roster | | | Before |
| 9/9/2008 | CTW | Pennington | Promoted to active roster | | | Before |
| 9/9/2008 | CTW | Smith,Jo | Promoted to active roster | | | Before |
| 9/9/2008 | CTW | Verlander | Promoted to active roster | | | Before |
| 9/9/2008 | RYS | Albers | Demoted to reserve roster | | | Before |
| 9/9/2008 | RYS | Pineiro | Activated from disabled list | | | Before |
| 9/9/2008 | RYS | Veras | Promoted to active roster | | | Before |
| 9/9/2008 | SOI | Hudson,T | Activated from disabled list | | | Before |
| 9/10/2008 | AST | Gerut | Demoted to reserve roster | | | Before |
| 9/10/2008 | AST | Litsch | Promoted to active roster | | | Before |
| 9/10/2008 | AST | Yates | Demoted to reserve roster | | | Before |
| 9/10/2008 | BRK | Bruney | Demoted to reserve roster | | | Before |
| 9/10/2008 | CTW | Garcia,F | Demoted to reserve roster | | | Before |
| 9/10/2008 | HAR | Ohlendorf | Demoted to reserve roster | | | Before |
| 9/10/2008 | NEP | Iannetta | Promoted to active roster | | | Before |
| 9/10/2008 | NEP | Nix,L | Demoted to reserve roster | | | Before |
| 9/10/2008 | NEP | Teagarden | Demoted to reserve roster | | | Before |
| 9/10/2008 | RMO | Pena,C | Demoted to reserve roster | | | Before |
| 9/10/2008 | SOI | Escobar,A | Demoted to reserve roster | | | Before |
| 9/11/2008 | CBB | Maddux | Demoted to reserve roster | | | Before |
| 9/11/2008 | CIO | Carpenter,C | Demoted to reserve roster | | | Before |
| 9/11/2008 | CTW | Blevins | Demoted to reserve roster | | | Before |
| 9/11/2008 | CTW | Garcia,J | Demoted to reserve roster | | | Before |
| 9/11/2008 | CTW | Millwood | Demoted to reserve roster | | | Before |
| 9/11/2008 | CTW | Smith,Jo | Demoted to reserve roster | | | Before |
| 9/11/2008 | CTW | Verlander | Demoted to reserve roster | | | Before |
| 9/11/2008 | FDH | Chavez,J | Demoted to reserve roster | | | Before |
| 9/11/2008 | FDH | Cotts | Promoted to active roster | | | Before |
| 9/11/2008 | FDH | Parnell | Promoted to active roster | | | Before |
| 9/11/2008 | SOI | Downs | Demoted to reserve roster | | | Before |
| 9/11/2008 | TEW | Sanchez,G | Demoted to reserve roster | | | Before |
| 9/12/2008 | AST | Bennett,J | Promoted to active roster | | | Before |
| 9/12/2008 | AST | LaRoche,Ad | Promoted to active roster | | | Before |
| 9/12/2008 | BRK | Izturis,C | Promoted to active roster | | | Before |
| 9/12/2008 | BRK | Kennedy,A | Promoted to active roster | | | Before |
| 9/12/2008 | BRK | Phillips,P | Promoted to active roster | | | Before |
| 9/12/2008 | CBB | Franklin | Demoted to reserve roster | | | Before |
| 9/12/2008 | CIO | Calero | Promoted to active roster | | | Before |
| 9/12/2008 | CIO | Drew,J | Demoted to reserve roster | | | Before |
| 9/12/2008 | CIO | Gutierrez | Promoted to active roster | | | Before |
| 9/12/2008 | CIO | Lind | Promoted to active roster | | | Before |
| 9/12/2008 | CIO | Ryan,Br | Promoted to active roster | | | Before |
| 9/12/2008 | HAR | Boggs,M | Demoted to reserve roster | | | Before |
| 9/12/2008 | TEW | Sheets | Demoted to reserve roster | | | Before |
| 9/13/2008 | AST | Maholm | Activated from disabled list | | | Before |
| 9/13/2008 | AST | Maholm | Demoted to reserve roster | | | Before |
| 9/13/2008 | CBB | Acosta | Promoted to active roster | | | Before |
| 9/13/2008 | CBB | Barton,B | Promoted to active roster | | | Before |
| 9/13/2008 | CBB | Casey | Promoted to active roster | | | Before |
| 9/13/2008 | CBB | Castillo,L | Promoted to active roster | | | Before |
| 9/13/2008 | CBB | Duncan,C | Promoted to active roster | | | Before |
| 9/13/2008 | CBB | Gonzalez,EV | Promoted to active roster | | | Before |
| 9/13/2008 | CBB | Herges | Promoted to active roster | | | Before |
| 9/13/2008 | CBB | Hermida | Promoted to active roster | | | Before |
| 9/13/2008 | CBB | Matthews | Promoted to active roster | | | Before |
| 9/13/2008 | CBB | Moehler | Promoted to active roster | | | Before |
| 9/13/2008 | CBB | Norton | Promoted to active roster | | | Before |
| 9/13/2008 | CBB | Pena,TR | Promoted to active roster | | | Before |
| 9/13/2008 | CBB | Roberts,D | Promoted to active roster | | | Before |
| 9/13/2008 | CBB | Rogers | Promoted to active roster | | | Before |
| 9/13/2008 | CBB | Sheffield | Promoted to active roster | | | Before |
| 9/13/2008 | CIO | Ryan,Br | Demoted to reserve roster | | | Before |
| 9/13/2008 | GAR | Rivera,Ma | Demoted to reserve roster | | | Before |
| 9/13/2008 | HAR | Chavez,Er | Demoted to reserve roster | | | Before |
| 9/13/2008 | PHI | Burke,J | Demoted to reserve roster | | | Before |
| 9/13/2008 | RMO | Dillon | Promoted to active roster | | | Before |
| 9/13/2008 | RMO | Gardner,B | Demoted to reserve roster | | | Before |
| 9/14/2008 | AST | Maholm | Promoted to active roster | | | Before |
| 9/14/2008 | AST | Shields,S | Demoted to reserve roster | | | Before |
| 9/14/2008 | AST | Slowey | Demoted to reserve roster | | | Before |
| 9/14/2008 | ATM | Branyan | Promoted to active roster | | | Before |
| 9/14/2008 | ATM | Dukes | Promoted to active roster | | | Before |
| 9/14/2008 | ATM | Eckstein | Promoted to active roster | | | Before |
| 9/14/2008 | ATM | Garciaparra | Promoted to active roster | | | Before |
| 9/14/2008 | ATM | Napoli | Promoted to active roster | | | Before |
| 9/14/2008 | ATM | Navarro | Promoted to active roster | | | Before |
| 9/14/2008 | ATM | Santiago | Promoted to active roster | | | Before |
| 9/14/2008 | FDH | Cruz,N | Demoted to reserve roster | | | Before |
| 9/14/2008 | RYS | Wells,R | Demoted to reserve roster | | | Before |
| 9/15/2008 | AST | Blackburn | Promoted to active roster | | | Before |
| 9/15/2008 | AST | Herrera,D | Demoted to reserve roster | | | Before |
| 9/15/2008 | AST | Herrera,D | Promoted to active roster | | | Before |
| 9/15/2008 | AST | Springer | Demoted to reserve roster | | | Before |
| 9/15/2008 | AST | Yates | Promoted to active roster | | | Before |
| 9/15/2008 | BBG | Carlin | Promoted to active roster | | | Before |
| 9/15/2008 | BBG | Casilla,S | Activated from disabled list | | | Before |
| 9/15/2008 | BBG | Hanigan | Demoted to reserve roster | | | Before |
| 9/15/2008 | BBG | Hanrahan | Demoted to reserve roster | | | Before |
| 9/15/2008 | BBG | Harrison | Promoted to active roster | | | Before |
| 9/15/2008 | BBG | Kennedy,I | Promoted to active roster | | | Before |
| 9/15/2008 | BBG | Olsen | Demoted to reserve roster | | | Before |
| 9/15/2008 | BBG | Perez,Ol | Demoted to reserve roster | | | Before |
| 9/15/2008 | BBG | Torrealba | Demoted to reserve roster | | | Before |
| 9/15/2008 | BBG | Wilson,C | Promoted to active roster | | | Before |
| 9/15/2008 | BRK | Balfour | Demoted to reserve roster | | | Before |
| 9/15/2008 | CIN | Feliz | Promoted to active roster | | | Before |
| 9/15/2008 | CIN | Perkins | Demoted to reserve roster | | | Before |
| 9/15/2008 | SOI | Valverde | Demoted to reserve roster | | | Before |
| 9/16/2008 | CIN | Kendrick,K | Demoted to reserve roster | | | Before |
| 9/16/2008 | FDH | Pena,TF | Demoted to reserve roster | | | Before |
| 9/16/2008 | RYS | Grabow | Demoted to reserve roster | | | Before |
| 9/16/2008 | RYS | Petit,Y | Demoted to reserve roster | | | Before |
| 9/17/2008 | AST | Herrera,D | Promoted to active roster | | | Before |
| 9/17/2008 | AST | Kuroda | Demoted to reserve roster | | | Before |
| 9/17/2008 | CIN | Cordero,F | Demoted to reserve roster | | | Before |
| 9/17/2008 | CIN | Logan | Promoted to active roster | | | Before |
| 9/17/2008 | CIN | Miller,A | Demoted to reserve roster | | | Before |
| 9/17/2008 | CIN | Villanueva | Promoted to active roster | | | Before |
| 9/17/2008 | CIO | Calero | Demoted to reserve roster | | | Before |
| 9/17/2008 | CIO | McClellan | Demoted to reserve roster | | | Before |
| 9/17/2008 | FDH | Towles | Demoted to reserve roster | | | Before |
| 9/17/2008 | GAR | Saito | Promoted to active roster | | | Before |
| 9/17/2008 | GAR | Valdez | Promoted to active roster | | | Before |
| 9/17/2008 | NYD | Eveland | Demoted to reserve roster | | | Before |
| 9/18/2008 | BAR | Helton | Demoted to reserve roster | | | Before |
| 9/18/2008 | CIO | Bartlett | Demoted to reserve roster | | | Before |
| 9/18/2008 | CIO | Eyre | Promoted to active roster | | | Before |
| 9/18/2008 | CIO | Gutierrez | Demoted to reserve roster | | | Before |
| 9/18/2008 | CIO | Masset | Promoted to active roster | | | Before |
| 9/18/2008 | CIO | Ojeda | Promoted to active roster | | | Before |
| 9/18/2008 | CIO | Pagan | Promoted to active roster | | | Before |
| 9/18/2008 | CIO | Thornton | Promoted to active roster | | | Before |
| 9/18/2008 | CTW | Hammel | Demoted to reserve roster | | | Before |
| 9/18/2008 | FDH | Denorfia | Promoted to active roster | | | Before |
| 9/18/2008 | FDH | Headley | Demoted to reserve roster | | | Before |
| 9/18/2008 | FDH | Kendrick,H | Activated from disabled list | | | Before |
| 9/18/2008 | FDH | Treanor | Promoted to active roster | | | Before |
| 9/18/2008 | GAR | Saito | Demoted to reserve roster | | | Before |
| 9/18/2008 | NEP | Galarraga | Demoted to reserve roster | | | Before |
| 9/18/2008 | RMO | Guerrero | Demoted to reserve roster | | | Before |
| 9/18/2008 | RYS | Lannan | Demoted to reserve roster | | | Before |
| 9/18/2008 | RYS | Lopez,Ja | Promoted to active roster | | | Before |
| 9/19/2008 | BAR | Duchscherer | Promoted to active roster | | | Before |
| 9/19/2008 | GAR | Lackey | Demoted to reserve roster | | | Before |
| 9/19/2008 | GAR | Park | Promoted to active roster | | | Before |
| 9/19/2008 | NEP | Guillen,J | Promoted to active roster | | | Before |
| 9/19/2008 | NEP | Hoffpauir | Promoted to active roster | | | Before |
| 9/19/2008 | NEP | Sexson | Promoted to active roster | | | Before |
| 9/20/2008 | AST | Giles | Demoted to reserve roster | | | Before |
| 9/20/2008 | ATM | Miles | Demoted to reserve roster | | | Before |
| 9/20/2008 | BAR | Duchscherer | Demoted to reserve roster | | | Before |
| 9/20/2008 | BAR | Guthrie | Demoted to reserve roster | | | Before |
| 9/20/2008 | BAR | Stockman | Demoted to reserve roster | | | Before |
| 9/20/2008 | CIN | Elbert | Promoted to active roster | | | Before |
| 9/20/2008 | CIN | Gonzalez,G | Promoted to active roster | | | Before |
| 9/20/2008 | CIN | Sanchez,A | Promoted to active roster | | | Before |
| 9/20/2008 | FDH | Cotts | Demoted to reserve roster | | | Before |
| 9/20/2008 | FDH | Denorfia | Demoted to reserve roster | | | Before |
| 9/20/2008 | FDH | Jones,Ad | Promoted to active roster | | | Before |
| 9/20/2008 | FDH | Karstens | Promoted to active roster | | | Before |
| 9/20/2008 | FDH | Loe | Promoted to active roster | | | Before |
| 9/20/2008 | GAR | Reyes,An | Promoted to active roster | | | Before |
| 9/20/2008 | GAR | Wakefield | Demoted to reserve roster | | | Before |
| 9/20/2008 | NEP | Geary | Demoted to reserve roster | | | Before |
| 9/20/2008 | NEP | Washburn | Promoted to active roster | | | Before |
| 9/21/2008 | ATM | Roberts,B | Demoted to reserve roster | | | Before |
| 9/21/2008 | BBG | Aceves | Promoted to active roster | | | Before |
| 9/21/2008 | BBG | Betancourt,R | Promoted to active roster | | | Before |
| 9/21/2008 | BBG | Betemit | Demoted to reserve roster | | | Before |
| 9/21/2008 | BBG | Hanrahan | Promoted to active roster | | | Before |
| 9/21/2008 | BBG | Hoffman | Promoted to active roster | | | Before |
| 9/21/2008 | BBG | Johnson,Jo | Promoted to active roster | | | Before |
| 9/21/2008 | BBG | Madson | Promoted to active roster | | | Before |
| 9/21/2008 | BBG | Marshall | Promoted to active roster | | | Before |
| 9/21/2008 | BBG | Oliver | Promoted to active roster | | | Before |
| 9/21/2008 | BBG | Olsen | Promoted to active roster | | | Before |
| 9/21/2008 | BBG | Perez,Ol | Promoted to active roster | | | Before |
| 9/21/2008 | BBG | Rodney | Promoted to active roster | | | Before |
| 9/21/2008 | BBG | Ruiz,R | Demoted to reserve roster | | | Before |
| 9/21/2008 | BBG | Torrealba | Promoted to active roster | | | Before |
| 9/21/2008 | CIN | Farnsworth | Promoted to active roster | | | Before |
| 9/21/2008 | CIN | Perkins | Promoted to active roster | | | Before |
| 9/21/2008 | CIN | Rauch | Promoted to active roster | | | Before |
| 9/21/2008 | CTW | Nippert | Demoted to reserve roster | | | Before |
| 9/21/2008 | PHI | Encarnacion | Demoted to reserve roster | | | Before |
| 9/21/2008 | RMO | Dillon | Demoted to reserve roster | | | Before |
| 9/21/2008 | RMO | Montanez | Signed | | | Before |
| 9/22/2008 | CIN | Elbert | Demoted to reserve roster | | | Before |
| 9/22/2008 | CTW | Millwood | Promoted to active roster | | | Before |
| 9/22/2008 | CTW | Reynolds,G | Demoted to reserve roster | | | Before |
| 9/22/2008 | FDH | Morton,Ch | Demoted to reserve roster | | | Before |
| 9/22/2008 | GAR | Geer | Promoted to active roster | | | Before |
| 9/22/2008 | GAR | Santana,E | Demoted to reserve roster | | | Before |
| 9/22/2008 | RYS | Grabow | Promoted to active roster | | | Before |
| 9/22/2008 | RYS | Lannan | Promoted to active roster | | | Before |
| 9/22/2008 | RYS | Lopez,Ja | Demoted to reserve roster | | | Before |
| 9/22/2008 | RYS | Veras | Demoted to reserve roster | | | Before |
| 9/22/2008 | SOI | Mendoza | Demoted to reserve roster | | | Before |
| 9/23/2008 | CIO | Eyre | Demoted to reserve roster | | | Before |
| 9/23/2008 | CIO | Sherrill | Promoted to active roster | | | Before |
| 9/23/2008 | FDH | Bailey,H | Promoted to active roster | | | Before |
| 9/23/2008 | FDH | Jepsen | Promoted to active roster | | | Before |
| 9/23/2008 | NEP | Peavy | Demoted to reserve roster | | | Before |
| 9/23/2008 | PHI | Burrell | Demoted to reserve roster | | | Before |
| 9/24/2008 | AST | Carlyle | Demoted to reserve roster | | | Before |
| 9/24/2008 | ATM | Camp | Promoted to active roster | | | Before |
| 9/24/2008 | ATM | Cook | Promoted to active roster | | | Before |
| 9/24/2008 | ATM | Devine | Promoted to active roster | | | Before |
| 9/24/2008 | ATM | League | Promoted to active roster | | | Before |
| 9/24/2008 | ATM | Motte | Activated from disabled list | | | Before |
| 9/24/2008 | ATM | Pelfrey | Promoted to active roster | | | Before |
| 9/24/2008 | ATM | Robertson,D | Promoted to active roster | | | Before |
| 9/24/2008 | ATM | Street | Promoted to active roster | | | Before |
| 9/24/2008 | CIN | Ausmus | Promoted to active roster | | | Before |
| 9/24/2008 | CIO | Ryan,Br | Promoted to active roster | | | Before |
| 9/24/2008 | CTW | Hammel | Promoted to active roster | | | Before |
| 9/24/2008 | CTW | Smith,Jo | Promoted to active roster | | | Before |
| 9/24/2008 | CTW | Verlander | Promoted to active roster | | | Before |
| 9/24/2008 | FDH | Jepsen | Demoted to reserve roster | | | Before |
| 9/24/2008 | GAR | Ludwick | Demoted to reserve roster | | | Before |
| 9/24/2008 | GAR | Petit,G | Promoted to active roster | | | Before |
| 9/24/2008 | NYD | Saunders | Demoted to reserve roster | | | Before |
| 9/24/2008 | RYS | Coffey | Promoted to active roster | | | Before |
| 9/24/2008 | RYS | Frasor | Promoted to active roster | | | Before |
| 9/24/2008 | RYS | Grabow | Demoted to reserve roster | | | Before |
| 9/24/2008 | RYS | Lannan | Demoted to reserve roster | | | Before |
| 9/24/2008 | RYS | Mijares | Demoted to reserve roster | | | Before |
| 9/24/2008 | RYS | Petit,Y | Promoted to active roster | | | Before |
| 9/24/2008 | TEW | Garza | Demoted to reserve roster | | | Before |
| 9/25/2008 | AST | Brown,A | Demoted to reserve roster | | | Before |
| 9/25/2008 | AST | Murphy,Dan | Demoted to reserve roster | | | Before |
| 9/25/2008 | ATM | Westbrook | Demoted to reserve roster | | | Before |
| 9/25/2008 | BBG | Aceves | Demoted to reserve roster | | | Before |
| 9/25/2008 | BRK | Wainwright | Demoted to reserve roster | | | Before |
| 9/25/2008 | CEN | Morales,K | Demoted to reserve roster | | | Before |
| 9/25/2008 | CIO | Pagan | Demoted to reserve roster | | | Before |
| 9/25/2008 | CIO | Raburn | Promoted to active roster | | | Before |
| 9/25/2008 | CIO | Roberts,R | Promoted to active roster | | | Before |
| 9/25/2008 | GAR | Pujols | Demoted to reserve roster | | | Before |
| 9/25/2008 | TEW | Hudson,O | Demoted to reserve roster | | | Before |
| 9/25/2008 | TEW | Loux | Demoted to reserve roster | | | Before |
| 9/26/2008 | AST | Mussina | Demoted to reserve roster | | | Before |
| 9/26/2008 | BAR | Contreras | Promoted to active roster | | | Before |
| 9/26/2008 | BAR | Haeger | Demoted to reserve roster | | | Before |
| 9/26/2008 | BRK | Wood,K | Demoted to reserve roster | | | Before |
| 9/26/2008 | CIN | Byrdak | Promoted to active roster | | | Before |
| 9/26/2008 | CIN | Cairo | Promoted to active roster | | | Before |
| 9/26/2008 | CIN | Chavez,R | Promoted to active roster | | | Before |
| 9/26/2008 | CIN | Kottaras | Promoted to active roster | | | Before |
| 9/26/2008 | CIN | Miller,C | Promoted to active roster | | | Before |
| 9/26/2008 | CIN | Pena,B | Promoted to active roster | | | Before |
| 9/26/2008 | CIN | Pierre | Placed on disabled list | | 9/20/2008 | Before |
| 9/26/2008 | CIN | Simon | Promoted to active roster | | | Before |
| 9/26/2008 | CIN | Valbuena | Promoted to active roster | | | Before |
| 9/26/2008 | CIO | Bartlett | Promoted to active roster | | | Before |
| 9/26/2008 | CIO | Drew,J | Promoted to active roster | | | Before |
| 9/26/2008 | CIO | Gutierrez | Promoted to active roster | | | Before |
| 9/26/2008 | CIO | Roberts,R | Demoted to reserve roster | | | Before |
| 9/26/2008 | CIO | Votto | Demoted to reserve roster | | | Before |
| 9/26/2008 | FDH | Bailey,H | Demoted to reserve roster | | | Before |
| 9/26/2008 | GAR | Johnson,M | Promoted to active roster | | | Before |
| 9/26/2008 | GAR | Lewis,S | Demoted to reserve roster | | | Before |
| 9/26/2008 | GAR | Rabelo | Promoted to active roster | | | Before |
| 9/26/2008 | GAR | Ramirez,Max | Promoted to active roster | | | Before |
| 9/26/2008 | GAR | Saccomanno | Promoted to active roster | | | Before |
| 9/26/2008 | GAR | Shoppach | Demoted to reserve roster | | | Before |
| 9/26/2008 | SOI | Granderson | Demoted to reserve roster | | | Before |